A5042936277- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Adenosine and Purinergic Signaling
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Genetic Associations and Epidemiology
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Hedgehog Signaling Pathway Studies
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Oral microbiology and periodontitis research
- Hepatitis C virus research
- Calcium signaling and nucleotide metabolism
- Hepatitis B Virus Studies
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
Nanchang University
2016-2025
Fourth Hospital of Changsha
2025
Hunan Normal University
2025
Second Affiliated Hospital of Nanchang University
2021-2025
First Affiliated Hospital of Jiangxi Medical College
2024
State Forestry and Grassland Administration
2023
First Affiliated Hospital of Nanchang University
2020
Augusta University Health
2016-2020
Sichuan University
2013
Beijing Institute of Genomics
2007-2012
By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic candidate gene approaches search for evidence such genetic First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders Tibetan Plateau (3,200–3,500 m) closely related lowland Han revealed significant divergence across eight SNPs located near EPAS1 . This encodes...
Abstract CD73, an ecto-5′-nucleotidase (NT5E), serves as immune checkpoint by generating adenosine (ADO), which suppresses activation through the A 2A receptor. Elevated CD73 levels in tumor tissues correlate with poor clinical outcomes. However, crucial source of activity within microenvironment remains unspecified. Here, we demonstrate that cancer-associated fibroblasts (CAFs) constitute prominent hi population human colorectal cancers (CRCs) and two − murine models, including a modified...
Forkhead box M1 (FOXM1) is a proliferation-associated transcription factor of the forkhead proteins superfamily, which includes four isoforms FOXM1a, b, c, and d. FOXM1 has been implicated in hepatocellular carcinoma (HCC) progression, but underlying molecular mechanism remains elusive. In this study, we aim to clarify basis for FOXM1-mediated HCC progression. Bioinformatic analysis was used explore differentially expressed genes predicting proliferation. The expression kinesin family member...
Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and regulated by various signalling pathways. Recently, we observed that mouse embryonic fibroblasts from CD38 knockout mice were significantly resistant to oxidative stress such as H2 O2 -induced injury hypoxia/reoxygenation-induced injury. In addition, also found protected ischaemia reperfusion through activating SIRT1/FOXOs-mediated antioxidative pathway. However, role in cardiac not explored. Here,...
Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic a variety aggressive human carcinomas including ovarian cancer. Therefore, chemotherapeutic agents inhibit have emerged as promising novel therapeutic drugs for cancer.In this study, we show Hh promoted cellular migration and invasion, whereas blockade with GANT61 suppressed invasion in cancer cells. After treatment GANT61, cDNA microarray analyses revealed changes many...
// Chao Shi 1 , Dengliang Huang Nonghua Lu 2 Dan Chen Minhong Zhang Yehong Yan 3 Libin Deng 4 Quqin 5 Hua 6 Shiwen Luo Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China Department Gastroenterology, General Surgery, Institute Translational Epidemiology and Biostatistics, School Public Health, Biochemistry Molecular Biology Tulane Cancer Center, University New Orleans, LA, USA Correspondence to: Luo, email: shiwenluo@ncu.edu.cn...
Tumor angiogenesis is essential for solid tumor progression, invasion and metastasis. The aim of this study was to identify potential signaling pathways involved in angiogenesis.Genetically engineered mouse models were used investigate the effects endothelial ARL13B(ADP-ribosylation factor-like GTPase 13B) over-expression deficiency on retinal cerebral vasculature. An intracranially transplanted glioma model a subcutaneously implanted melanoma employed examine ARL13B growth angiogenesis....
Chemotherapy resistance is the main cause of ovarian cancer progression and even death. However, there are no clear indicators for predicting risk drug in patients. Intra-tumor heterogeneity (ITH) one characteristics malignant tumors, which associated with treatment prognosis tumors. Accordingly, our study aims to investigate correlation between image features intra-tumor based on artificial intelligence.
We report the follow-up spectroscopic confirmation of two lensed quasars, six dual and eleven projected quasars that were previously identified as lensed-quasar candidates in \cite{He2023}. The data obtained from different sources: P200/DBSP California publicly available datasets, including SDSS DESI-EDR. (both pairs) have following properties: $\theta_E$ = 1.208'', $z_s$ 3.105; 0.749, 2.395. redshifts ranging 0.58 to 3.28 separations 15.44 22.54 kpc, with a mean separation 17.95 kpc. 10.96...
We report the results of a follow-up spectroscopic confirmation two lensed quasars, six dual and eleven projected quasars that had previously been identified as lensed-quasar candidates in our earlier work. The data were obtained from different sources: Palomar 200-inch Double Spectrograph (P200/DBSP) California publicly available datasets, including SDSS DESI-EDR. (both pairs) have following properties: theta_E = 1arcsec.208, z_s 3.105; 0arcsec.749, 2.395. redshifts ranging 0.58 to 3.28...
Abstract Gravitationally strongly lensed quasars (SL-QSO) offer invaluable insights into cosmological and astrophysical phenomena. With the data from ongoing next-generation surveys, thousands of SL-QSO systems can be discovered expectedly, leading to unprecedented opportunities. However, challenge lies in identifying enormous sets with high recall purity an automated efficient manner. Hence, we developed a program based on convolutional neural network (CNN) for finding large-scale surveys...
Radiation-induced structural abnormalities in white matter (WM) have been reported patients with nasopharyngeal carcinoma (NPC); however, the alterations functional domain were insufficiently investigated. A total of 111 NPC included and these patients, based on whether completed radiation therapy (RT) or not, divided into pre-RT ( n = 47) post-RT 64) groups. Functional connectivity strength (FCS) between WM regions (WW-FCS) gray (GM) (GW-FCS) was used to investigate radiation-induced...
Metastasis is the major cause of cancer-related death in breast cancer patients, which controlled by specific sets genes. Targeting these genes may provide a means to delay progression and allow local treatment be more effective. We report for first time that ADP-ribosylation factor 1 (ARF1) most amplified gene ARF family cancer, high-level amplification ARF1 associated with increased mRNA expression poor outcomes patients cancer. Knockdown leads significant suppression migration invasion...
SWItch/Sucrose NonFermentable (SWI/SNF) is a set of multi-subunits chromatin remodeling complexes, playing important roles in variety biological processes. Loss-of-function mutations the genes encoding SWI/SNF subunits have been reported more than 20% human cancers. Thus, it was widely considered as tumor suppressor past decade. However, recent studies that some complexes were amplified and play oncogenic In present study, we summarized genetic alteration spectrum firstly systematically...
In the present study, we analyzed schizophrenia (SCZ)‑related genome‑wide association studies (GWAS) to identify genes and pathways associated with SCZ. We identified 1,098 common (1,098/9,468) 20 shared KEGG (both P<0.01) by integrating candidate from European American SCZ‑related GWAS. The related axon guidance, long term potentiation arrhythmogenic right ventricular cardiomyopathy (ARVC) were highly significant (P<10‑3). Moreover, 15 guidance pathway‑related between pathway SCZ was...
Abstract Background Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change biological features complicating progression liver diseases. However, clinical conditions correlating accumulation deleted mutants remain unclear. In this study, we explored deletion patterns their association with disease status antiviral treatment by performing...