A5100439716- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Adrenal and Paraganglionic Tumors
- Circular RNAs in diseases
- Urinary Bladder and Prostate Research
- Head and Neck Anomalies
- Acute Ischemic Stroke Management
- Urinary and Genital Oncology Studies
- Cerebrovascular and Carotid Artery Diseases
- Thyroid Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Hormonal Regulation and Hypertension
- Organ Donation and Transplantation
- Nuts composition and effects
- Coronary Artery Anomalies
- FOXO transcription factor regulation
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Glioma Diagnosis and Treatment
Shuguang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
First Bethune Hospital of Jilin University
2024
Nanchang University
2016-2023
First Affiliated Hospital of Nanchang University
2016-2023
Forkhead box M1 (FOXM1) is a proliferation-associated transcription factor of the forkhead proteins superfamily, which includes four isoforms FOXM1a, b, c, and d. FOXM1 has been implicated in hepatocellular carcinoma (HCC) progression, but underlying molecular mechanism remains elusive. In this study, we aim to clarify basis for FOXM1-mediated HCC progression. Bioinformatic analysis was used explore differentially expressed genes predicting proliferation. The expression kinesin family member...
The long non-coding RNA LINC00467 plays a vital role in many malignancies. Nevertheless, the of prostate carcinoma (PC) is unknown. Herein, we aimed to explore mechanism by which regulates PC progression. We used bioinformatics analyses and RT-qPCR investigate expression tissues cells. function progression was confirmed loss-of-function experiments. cell proliferation assessed CCK-8 EdU assays. cycle cells examined flow cytometry. Moreover, Transwell assays were migration invasion Western...
Abstract Background Cuproptosis, an emerging form of programmed cell death, has recently been identified. However, the association between cuproptosis-related long non-coding RNA (lncRNA) signature and prognosis in prostate carcinoma remains elusive. This study aims to develop novel lncRNA cancer explore its latent molecular function. Methods RNA-seq data clinical information were downloaded from TCGA datasets. Then, gene was identified previous literature further applied screen...
Gastric cancer (GC) remains one of prevalent causes cancer‐related deaths worldwide. Long noncoding RNA is related to various cancers. Our study was conducted explore the biological effects LINC00240 on tumorigenesis GC and uncover its possible mechanisms. expression determined in cell lines samples through quantitative Real‐time Polymerase Chain Reaction (qRT‐PCR). The functional were validated using vitro vivo assays. Targets assessed by AGO2‐dependent immunoprecipitation assay...
To assess the perioperative, functional, and oncological outcomes of transvesical robot-assisted radical prostatectomy (T-RARP) posterior (P-RARP) for localized prostate cancer.We analyzed data 96 patients who underwent T-RARP or P-RARP cancer between January 2017 June 2019 in a retrospective fashion.No significant differences baseline characteristics existed arms. Both interventions were successfully performed without open conversion either group. was associated with slightly more operative...
To estimate the safety and efficiency of transvesical Retzius-sparing robot-assisted radical prostatectomy (T-RARP) compared with standard (S-RARP) for localized prostate cancer (PCa).174 patients bearing PCa undergoing T-RARP or S-RARP between October 2017 January 2020 were retrospectively enrolled in our analysis. All potential baseline confounders strictly restrained propensity-score matching (PM) method (1: 1). Within matched setting, perioperative functional outcomes groups, while...
Abstract Background Glioblastoma (GBM) remains the most biologically aggressive subtype of gliomas with an average survival 10 to 12 months. Considering that overall (OS) each GBM patient is a key factor in treatment individuals, it meaningful predict probability for patients newly diagnosed clinical practice. Material and Methods Using TCGA dataset two independent GEO datasets, we identified genes are associated OS differentially expressed between tissues adjacent normal tissues. A robust...
This work explores the clinical significance of Delphian lymph nodes (DLN) in thyroid papillary carcinoma (PTC). At same time, a nomogram is constructed based on clinical, pathological, and ultrasonic (US) features to evaluate possibility DLN metastasis (DLNM) PTC patients. first study predict DLNM using US characteristics.A total 485 patients, surgically diagnosed with between February 2017 June 2021, all whom underwent thyroidectomy, were included study. Using information related factors...
Abstract Rationale: Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue lesion, originally reported in the lungs. Occurrence of IMT was also documented digestive system, but urinary especially urachus, and little presently known about IMT. Patient concerns: This study very case urachal an elderly female patient at age 77 who diagnosed with lower abdominal mass 2 months ago. Diagnosis: The preoperative diagnosis carcinoma, which confirmed to be anaplastic lymphoma kinase (ALK)...
Aim. To evaluate the urinary continence (UC), erectile function, and cancer control obtained following robot-assisted radical prostatectomy (RARP) laparoscopic (LRP) for intermediate- high-risk localized prostate (PCa). Materials Methods. 232 patients bearing PCa were enrolled in this study. Perioperative, functional, oncological outcomes analyzed after applying propensity score matched method. Results. Within cohort, RARP group was corrected with a significantly shorter mean operative time...
To compare the efficacy and safety between conservative treatment surgery for patients with small (1-3cm) nonfunctional adrenal incidentaloma (NFAI). The NFAI who received or in our hospital from November 2018 to December 2019 were retrospectively collected. A total of 83 included this study. They divided into two groups according methods: group (n=51) (n=32).Then patients' demographics, tumor characteristics, functional indicators complications compared. Statistical analysis was performed...
The aim of this study was to identify novel genetic features Hunner's lesion interstitial cystitis (HIC) via comprehensive analysis the Gene Expression Omnibus (GEO) database.The GSE11783 and GSE28242 datasets were downloaded from GEO for further analysis. Differentially expressed genes (DEGs) identified analyzed functional annotation. diagnostic markers HIC screened validated using least absolute shrinkage selection operator (LASSO) logistic regression support vector machine recursive...
Objective: The aim of this study was to introduce the “ultrathin parenchyma” resection in a robot-assisted partial nephrectomy (RAPN) via retroperitoneal approach, and assess feasibility, security, effectiveness technique. Methods: We collected retrospectively reviewed clinical data patients with renal tumors who underwent ultrathin parenchyma resections RAPNs approach or traditional sharp dissection from February 2015 August 2018. general other parameters, such as operation time, blood loss...
303 Background: In 2016, we reported the preliminary results of APL-1202, an oral MetAP2 inhibitor, in first 18 patients enrolled phase II trial. The purpose present study is to update efficacy, safety, pharmacokinetics at steady state and translational studies 41 patients. Methods: This open-label, single-arm trial conducted 15 hospitals China. High-risk recurrence defined according EORTC score probability tables EAU 2012 Guidelines on NMIBC. primary end point recurrence-free survival rate...
The current study aimed to investigate the imaging characteristics and pathogenesis of intracranial artery stenosis in patients with acute cerebral infarction. In total, 84 diagnosed infarction were recruited. Magnetic resonance angiography was performed detect existence or occlusion. addition, magnetic diffusion weighted employed analyze types characteristics. majority patients, resulted from internal carotid (77 cases; 91.7%), while it caused by vertebral a small number cases (7 8.3%)....
The aim of the present study was to explore expression profile and potential regulatory mechanism two long non-coding RNAs (lncRNAs) (RP13-650J16.1 TCONS_00023979) in prostate cancer (PCa). Expression lncRNAs PCa paracancerous tissues were investgated by high-throughput gene chip technology. Specific siRNA RP13-650J16.1 or TCONS_00023979 transfected into DU145 cells. Then, relative RP13-650J16.1, receptor-associated coactivator 3 (RAC3), promyelocytic leukemia (PML), detected quantitative...
To evaluate the prognostic value of aspartate transaminase/alanine transaminase (AST/ALT) ratio in primary non-muscle-invasive bladder cancer (NMIBC) using propensity score matching (PSM) analysis.We retrospectively collected clinical and pathological data from 314 patients with NMIBC who underwent transurethral resection tumor. The full cohorts were divided into a low AST/ALT group high according to optimal cut-off which was obtained based on analysis receiver operating characteristic curve...
Rationale: The left anomalous coronary artery originating from the opposite sinus represents a distinct subtype of arteries sinus. A comprehensive overview encompassing clinical characteristics, diagnostic approaches, and treatment modalities for this condition is presented herein. Patient concerns: patient, 17-year-old female, was admitted to hospital due chest pain syncope following multiple exercises. Diagnoses: After conducting an electrocardiogram, myocardial injury markers,...
Background Dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) can reflect the angiogenesis of ischemic stroke. Purpose To investigate value DSC-MRI with ultrasmall superparamagnetic particles iron oxides (USPIO) in evaluating peri-infarction zones subacute stroke a permanent middle cerebral artery occlusion (pMCAO) rat model. Material and Methods A total 21 Sprague–Dawley rats were randomly divided into pMCAO sham operation groups. Every each group underwent USPIO...
Abstract Background Emerging evidence has shown that miR-1307-5p is involved in tumorigenesis of various types cancer. This study aims to assess the role and mechanism bladder Methods Bioinformatics analyses were carried out with clinical datasets public domains. To investigate cellular functions miR-1307-5p, assays cell proliferation, cycle apoptosis conducted cancer lines xenografts. The molecular mechanisms studied using luciferase reporter, RT-qPCR, western blotting analyses. Results We...
To propose an original and standardized scoring system to quantify the functional anatomical characteristics of adrenal tumor. Four groups consecutive adrenalectomies (n = 458) with heterogeneity in tumor surgical approaches, including 212 laparoscopic cases (Group 1) 105 robotic 2) from The First Affiliated Hospital Nanchang University, 28 Temple University 3) 113 Guangxi Medical 4). All patients were followed up for 4.5 5.5 years. Six parameters status or suspicion malignancy, size,...
Abstract Background: The prognostic risk of non-metastatic clear cell renal carcinoma (ccRCC) with venous tumor thrombus (VTT) is variable among individual patients following radical nephrectomy and thrombectomy. However, the potential multiple pathological features VTT are unexploited, stratification models specific for these lacking. Patients methods: This retrospective, nationwide cohort comprised 1263 ccRCC from multicentre, including Training (n=664), China-validation (n=517)...