A5101587050- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Plant Gene Expression Analysis
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Plant Reproductive Biology
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Photosynthetic Processes and Mechanisms
- Epigenetics and DNA Methylation
Hebei Agricultural University
2023-2025
Sun Yat-sen University
2014-2024
Sun Yat-sen University Cancer Center
2014-2024
Nanjing Agricultural University
2024
State Key Laboratory of Oncology in South China
2014-2023
Shenyang Agricultural University
2020-2022
He Eye Hospital
2019-2022
First Affiliated Hospital of Nanchang University
2017-2021
Nanchang University
2017-2021
Cancer Institute (WIA)
2021
Summary Glomerella leaf spot (GLS), caused by the fungus Colletotrichum fructicola , is considered one of most destructive diseases affecting apples. The VQ‐WRKY complex plays a crucial role in response plants to biotic stresses. However, our understanding defensive on woody plants, particularly apples, under stress, remains limited. In this study, we elucidated molecular mechanisms underlying apple MdVQ37‐MdWRKY100 module GLS infection. overexpression MdWRKY100 enhanced resistance C ....
Early stage lung cancer detection is the first step toward successful clinical therapy and increased patient survival. Clinicians monitor progression by profiling tumor cell proteins in blood plasma of afflicted patients. Blood plasma, however, a difficult protein assessment medium because it rich albumins heterogeneous species. We report herein method to detect released into circulatory system cells. Initially we analyzed components conditioned (CM) primary or organ cultures adjacent normal...
Purpose To explore the characteristics of C-TIRADS by comparing it with ACR-TIRADS, Kwak-TIRADS, KSThR-TIRADS and EU-TIRADS. Methods A total 1096 nodules were collected from 884 patients undergoing thyroidectomy in our center between May 2018 December 2020. Divided into two groups: “>10mm” “≤10mm”. Ultrasound each nodule observed recorded 2 doctors, then classified based on KSThR-TIRADS, EU-TIRADS, C-TIRADS. Results 682 benign cases (62.23%) 414 malignant (37.77%) identified. The ICC...
N6-methyladenosine (m6A) is the most common internal modification in mRNAs of all higher eukaryotes. Here we perform two high-throughput sequencing method, m6A-modified RNA immunopreciplation sequence (MeRIP-seq) and (RNA-seq) to identify key genes with m6A cashmere fiber growth. Total 9085 peaks were differentially expressed as defined by MeRIP-seq, including 7170 upregulated 1915 downregulated. In addition, comparing between fine-type Liaoning goat (FT-LCG) corse-type (CT-LCG) skin...
Abiotic stress reduces plant yield and quality. WRKY transcription factors play key roles in abiotic responses plants, but the molecular mechanisms by which mediate to drought osmotic stresses apple (Malus × domestica Borkh.) remain unclear. Here, we functionally characterized Group III gene MdWRKY115. qRT-PCR analysis showed that MdWRKY115 expression was up-regulated stresses. GUS activity revealed promoter of enhanced under stress. Subcellular localization transactivation assays indicated...
Abstract PURPOSE: Expression of targeting protein for Xklp2 (TPX2), a microtubule-associated protein, is tightly cell cycle regulated. Abnormally expressed TPX2 has been reported in various malignancies, but less known lung cancer. The present study appraised the significance aberrant expression tumorigenesis and progression human squamous carcinoma (SCC) lung. EXPERIMENTAL DESIGN AND RESULTS: expressive status was firstly examined with cancer (L, PAa, PG) immortalized bronchial epithelial...
Circular RNA (circRNA) is endogenous non-coding (ncRNA) with a covalently closed circular structure. It mainly generated through alternative splicing or back-splicing. CircRNA known in the majority of eukaryotes and very stable. However, knowledge circRNA involved regulating cashmere fineness limited. Skin samples were collected from Liaoning goats (LCG) Inner Mongolia (MCG) during anagen period. For differentially expressed circRNAs, sequencing was performed, analysis led to an...
Enzymatic browning has a considerable negative impact on the acceptability and marketability of freshly cut apples. However, molecular mechanism by which selenium (Se) positively affects apples in this regard is not yet clear. In study, 0.75 kg/plant Se-enriched organic fertilizer was applied to "Fuji" apple trees during young fruit stage (M5, May 25), early enlargement (M6, June (M7, July respectively. The same amount Se-free as control. Herein, regulatory exogenous Se exerts its...
Tubby-like proteins (TLPs) constitute a diverse multigene family found across broad range of eukaryotic organisms, from single-celled to multicellular eukaryotes. Despite their importance, the existence TLPs in walnuts (Juglans regia L.) has not been reported until now. In this study, we identified 12 members JrTLP gene walnut genome, revealing pattern replication events. Notably, all JrTLPs exhibited split structure, containing two eight introns, and these genes could be divided into five...
8008 Background: Enhancing clinical outcomes in resectable non-small cell lung cancer (NSCLC) has been associated with neoadjuvant or perioperative administration of nivolumab. However, the efficacy and safety consolidation nivolumab versus observation following chemotherapy plus nivolumab, hypofractionated radiotherapy concurrent (hypo-CCRT) patients unresectable stage III NSCLC remain underexplored. Methods: Conducted as a randomized, multi-center, phase 2 trial IIIA-C NSCLC, this study...
Purpose This study aimed to develop a nomogram for predicting pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC) by integrating hematological biomarkers and clinicopathological characteristics.Materials Methods Between 2003 2017, 306 ESCC who underwent CRT followed esophagectomy were analyzed. Besides factors, parameters before, during, collected. Univariate multivariate logistic regression analyses...
Ovarian cancer is the most lethal gynecological malignancy worldwide, and early detection of this disease using serum or plasma biomarkers may improve its clinical outcome. In present study, a large scale protein database derived from ovarian was created to enable tumor marker discovery. First, primary organ cultures were established with tissues corresponding normal obtained six patients, serum-free conditioned medium (CM) samples collected for proteomic analysis. The total proteins CM...
Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess prognostic factors with postoperative locoregionally recurrent NSCLC treated radiotherapy.We reviewed medical records 74 locoregional who received between April 2012 February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China). The efficacy safety were...