A5100746535- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Science, Research, and Medicine
- Lung Cancer Treatments and Mutations
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Heat shock proteins research
- Colorectal and Anal Carcinomas
- Lung Cancer Diagnosis and Treatment
- Virus-based gene therapy research
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Sichuan Agricultural University
2024
Tianjin University of Technology
2024
Shanxi Medical University
2023
Peking Union Medical College Hospital
2016-2022
University of Chinese Academy of Sciences
2022
Second Affiliated Hospital of Zhejiang University
2022
Chinese Academy of Sciences
2022
Beihang University
2022
State Key Laboratory of Molecular Oncology
2019
Background Neutrophil extracellular traps (NETs) were originally thought to be formed by neutrophils trap invading microorganisms as a defense mechanism. Increasing studies have shown that NETs play pivotal role in tumor progression and diffusion. In this case, transcriptome analysis provides an opportunity unearth the association between clinical outcomes of patients with pan-cancer. Methods The sequencing data Cancer Genome Atlas pan-cancer primary focus was obtained from UCSC Xena,...
Crosstalk between RNAs mediated by shared microRNAs (miRNAs) represents a novel layer of gene regulation, which plays important roles in development. In this study, we analyzed time series expression data for coding genes and long non-coding (lncRNAs) to identify thousands interactions among competitive endogenous (ceRNAs) four rhesus tissues. The ceRNAs exhibited dynamic regulatory patterns during each tissue development process, suggests that might work synergistically different...
Abstract Intestinal‐type gastric cancer (IGC) has a clear and multistep histological evolution. No studies have comprehensively explored tumorigenesis from inflammation through low‐grade intraepithelial neoplasia (LGIN) high‐grade (HGIN) to early (EGC). We sought investigate the characteristics participating in IGC identify related prognostic information within process. RNA expression profiles of 94 gastroscopic biopsies 47 patients, including precancerous lesions (GPL: LGIN HGIN), EGC,...
// Honglin Guo 1, * , Weigen Zeng 2, Lin Feng 1 Xuexin Yu 3 Ping Li Kaitai Zhang Zhixiang Zhou 4 and Shujun Cheng State Key Laboratory of Molecular Oncology, Department Etiology Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing 100021, China 2 General Surgery, Chao-Yang Capital University, 100020, College Bioinformatics Science Technology, Harbin 150081, Colorectal These authors contributed to the work equally should be...
The tumor environment is of vital importance for the incidence and development colorectal cancer. Increasing evidence in recent years has elaborate role cancer-subtype classification patients' prognosis, but a comprehensive understanding purely depending on stromal compartment lacking. To decipher features cancer explore its immune context composition classification, we performed gene expression microarray microdissection-processed compartments adjacent normal tissues. Through integrated...
Most renal cell carcinoma (RCC) patients die from metastasis or recurrence after the spread of cancer to another organ, but mechanisms underlying intravascular survival circulating tumor cells (CTCs) are incompletely deciphered. Additionally, although elevated plasma C-reactive protein (CRP) levels and thrombocytosis strongly correlated both indicate a poor prognosis for RCC patients, bridge connecting inflammation coagulation remains poorly understood. To explore complicated relationship...
Intratumoral heterogeneity has been revealed in primary liver carcinoma (PLC). However, spatial of tumor-infiltrating lymphocytes (TILs), which reflects one dimension a tumor's heterogeneity, and the relationship between TIL diversity, local immune response mutation burden remain unexplored PLC. Therefore, we performed repertoire sequencing, gene expression profiling analysis whole-exome sequencing parallel on five regions each tumor matched adjacent normal tissues peripheral blood from PLC...
Abstract Understanding the interactions between tumors and host immune system holds great promise to uncover biomarkers for targeted therapies, predict prognosis of patients guide clinical treatment. However, signatures glioblastoma multiforme (GBM) remain largely unstudied in terms systematic analyses. We aimed classify GBM samples according immune‐related genes complement existing immunotherapy knowledge. In this study, we designed a strategy identify 3 subtypes representing different...
BACKGROUND:MicroRNAs (miRNAs) are attracting substantial interest as promising noninvasive biomarkers for gastric cancer (GC). Our study aimed to identify circulating miRNAs that potential markers precancerous lesions and early cancers (EGCs). MATERIAL AND METHODS:Plasma specimens were obtained from 58 gastritis subjects, 54 patients with lesions, 38 EGC study. RESULTS:Significant differences in the plasma expression levels of miR-19a-3p, miR-22-3p, miR-146a-5p, miR-483-5p (all P<0.05)...
Signet ring cell carcinoma (SRCC) has specific oncogenesis and phenotypic treatment resistance heterogeneity. Systemic therapies are often ineffective, predictive biomarkers to guide urgently needed. Tumor organoids have recently emerged as an ideal model for drug testing screening. Here, we report gastric established from tumor tissues comprising four SRCCs eight non-SRCCs. demonstrated different growth characteristics morphologies. Changes in the original genome were maintained during...
Abstract Background Pancreatic cancer is a malignancy with high mortality. Once diagnosed, effective treatment strategies are limited and the five-year survival extremely poor. Recent studies have shown that zinc finger proteins play important roles in tumorigenesis, including pancreatic cancer. However, it remains unknown on clinical significance, function underlying mechanisms of protein 488 (ZNF488) during development Methods The relevance ZNF488 stearoyl-CoA desaturase 1 (SCD1) was...
Abstract Background The spatial context of tumor-infiltrating immune cells (TIICs) is important in predicting colorectal cancer (CRC) patients’ clinical outcomes. However, the prognostic value TIIC distribution unknown. Thus, we aimed to investigate association between TIICs situ and patient prognosis a large CRC sample. Methods We implemented multiplex immunohistochemistry staining technology 190 samples quantify 14 subgroups situ. To delineate relationship tumor cells, tissue slides were...
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation, affecting physiological and pathological processes. Fatty liver disease associated with metabolic dysfunction common condition in aquaculture. However, the exact role mechanism ferroptosis its pathogenesis progression remains unclear. In this study, an experiment was conducted using different dietary levels feeding largemouth bass (
Although several researches have explored the similarity across development and tumorigenesis in cellular behavior underlying molecular mechanisms, not many investigated developmental characteristics at proteomic level further extended to cancer clinical outcome. In this study, we used iTRAQ quantify protein expression changes during macaque rhesus brain from fetuses gestation 70 days after born 5 years. Then, performed weighted gene co-expression network analysis (WGCNA) on data of identify...
Breast cancer is a heterogeneous disease, and although advances in molecular subtyping have been achieved recent years, most strategies target individual genes independent of one another primarily concentrate on proliferative markers. The contributions biological processes immune patterns neglected breast subtype stratification.We performed gene set variation analysis to simplify the information using hallmark terms decompose cell data 985 invasive ductal/lobular carcinoma RNAseq samples...
Circulating tumour cell (CTC) behaviours are distinct from those of bulk tissues. Thus, treatments to eliminate CTCs differ the regimens followed reduce primary and its metastases. Accordingly, comprehensively deciphering single nucleotide variant (SNV) profiles in CTCs, which partially determine CTC behaviours, is a priority. Using viable isolated with oHSV1‑hTERT‑GFP virus coupled fluorescence‑activated sorting (FACS), whole genome was amplified using multiple annealing looping‑based...
Abstract T cells and cell receptors (TCRs) play pivotal roles in adaptive immune responses against tumors. The development of next-generation sequencing technologies has enabled the analysis TCRβ repertoire usage. Given scarce investigations on TCR lung cancer tissues, this study, we analyzed repertoires tissues matched distant non-tumor (normal tissues) from 15 patients. Based our results, general distribution clones was similar between normal tissues; however, proportion highly expanded...
The co-evolving tumour cells and the systemic immune environment are mutually dysregulated. Tumours affect response in a complex manner. For example, although lymphocytes mobilized to tumours, their function is impaired by progression. This study aimed explore how baseline dynamic renal cell carcinoma (RCC) burdens T-cell repertoire, whether receptor β-chain (TCRB) diversity predicts prognosis. To characterise TCRB follow-up peripheral repertoires of 45 patients with RCC 2 benign disease...