A5101889812- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Virus-based gene therapy research
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Natural Language Processing Techniques
- Bacteriophages and microbial interactions
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- Topic Modeling
- DNA Repair Mechanisms
- Genetic Syndromes and Imprinting
- Lipid metabolism and biosynthesis
- TGF-β signaling in diseases
- Advanced Breast Cancer Therapies
- ECG Monitoring and Analysis
- Metabolism and Genetic Disorders
- RNA Interference and Gene Delivery
- Occupational and environmental lung diseases
- Advanced Neural Network Applications
Fujian Agriculture and Forestry University
2025
First People's Hospital of Yunnan Province
2024
Kunming University of Science and Technology
2024
Shandong Provincial Hospital
2013-2023
Shandong First Medical University
2023
Shandong Center for Disease Control and Prevention
2023
Shanghai Clinical Research Center
2023
Fudan University
2023
Unimed Medical Institute
2018-2021
Shandong University
2013-2021
Epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations represent approximately 4-12% of EGFR and are generally refractory to the 1st 2nd generation tyrosine kinase inhibitors (TKIs). Development effective therapies for patients with EGFRex20ins mutant non-small-cell lung carcinoma (NSCLC) represents a great unmet need. Preclinical models have shown that osimertinib is active in NSCLC harboring EGFRex20ins, while antitumor activity remains be evaluated mutations.Tumor...
Alterations in DNA damage repair (DDR) genes produce therapeutic biomarkers. However, the characteristics and significance of DDR alterations remain undefined primary liver cancer (PLC).Patients diagnosed with PLC were enrolled trial (PTHBC, NCT02715089). Tumors matched blood samples from participants collected for a targeted next-generation sequencing assay containing exons 450 cancer-related genes, including 31 genes. The OncoKB knowledge database was used to identify classify actionable...
Abstract Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during resistance (IR), when signalling is blunted and accompanied by hyperinsulinaemia, the promotion of DNL continues unabated steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) IR. Mechanistically, WDR6 interacts with beta-type catalytic subunit serine/threonine-protein phosphatase 1 (PPP1CB) to facilitate PPP1CB dephosphorylation at Thr316, which subsequently...
Hepatocellular carcinoma (HCC) is one of the most common causes cancer worldwide. Although many studies have focused on oncogene characteristics, genomic landscape Chinese HCC patients has not been fully clarified.A total 165 patients, including 146 males and 19 females, were enrolled. The median age was 55 years (range, 27-78 years). Corresponding clinical pathological information collected for further analysis. A 168 tumor tissues from these selected next-generation sequencing (NGS)-based...
The common method of delivering CRISPR/Cas reagents for genome editing in plants involves Agrobacterium-mediated transformation or preassembled CRISPR/Cas9 ribonucleoprotein complex delivery (Woo et al., 2015; Toda 2019; Ye 2020). These methods require labor-intensive and time-consuming plant tissue culture processes (Huang 2022). Unfortunately, most exhibit extremely low efficiency callus induction regeneration; these technical challenges greatly hinder the application editing. Recent...
// Honglin Guo 1, * , Weigen Zeng 2, Lin Feng 1 Xuexin Yu 3 Ping Li Kaitai Zhang Zhixiang Zhou 4 and Shujun Cheng State Key Laboratory of Molecular Oncology, Department Etiology Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences Peking Union College, Beijing 100021, China 2 General Surgery, Chao-Yang Capital University, 100020, College Bioinformatics Science Technology, Harbin 150081, Colorectal These authors contributed to the work equally should be...
Patients with non-small cell lung cancer (NSCLC) containing ROS1 fusions can have a marked response to the ROS1-targeted tyrosine kinase inhibitors (TKIs), such as crizotinib. Common resistance mechanisms of ROS1-fusion targeted therapy are acquired mutations in ROS1. Along use next-generation sequencing clinical management patients NSCLC during sequential therapy, many been discovered activated receptors. Besides mutations, bypass epidermal growth factor receptor (EGFR)-TKI treatment common...
Patients with Prader-Willi syndrome (PWS) have a reduced life expectancy due to inflammation-related disease including cardiovascular and diabetes. Abnormal activation of peripheral immune system is postulated as contributor. However, detailed features the cells in PWS not been fully elucidated.Serum inflammatory cytokines were measured healthy controls (n=13) patients (n=10) using 65- multiplex cytokine assays. Changes was assessed by single-cell RNA sequencing (scRNA-seq) high-dimensional...
Kai Lv, Shuo Zhang, Tianle Gu, Shuhao Xing, Jiawei Hong, Keyu Chen, Xiaoran Liu, Yuqing Yang, Honglin Guo, Tengxiao Yu Sun, Qipeng Hang Yan, Xipeng Qiu. Proceedings of the 2023 Conference on Empirical Methods in Natural Language Processing: System Demonstrations. 2023.
Despite many striking connections, the biological similarities between embryonic development and tumorigenesis have not been well explored. Development of placental villi is a crucial process involving cellular activities, including immunity, proliferation, cell adhesion. In this study, we designed strategy to identify gene expression pattern explore corresponding features in tumors. We discovered villi-specific genes that are highly expressed villus as opposed mature placenta then measured...
Abstract Background: Breast cancer is the most common malignancy in women worldwide and important therapeutic progress has been achieved over past decade. The identification of new biomarkers breast urgently needed to stratify populations who may benefit from personalized therapies. Defects homologous recombination DNA damage repair (HR-DDR) pathway sensitizes tumors therapeutics that target this pathway, such as (PARP) inhibitors. aim our study was determine prevalence HR-DDR pathogenic...
8540 Background: Lung squamous cell carcinoma (LUSC) is a major histological subtype of non-small lung cancer (NSCLC) and accounts for 30% NSCLC. Previous studies had revealed the genomic characterization LUSC in Western patients (pts). However, comprehensive features Chinese pts have not been well understood. Methods: Deep sequencing targeting 450 genes was performed on FFPE matching blood samples collected from 311 pts. Genomic alterations (GAs) including single nucleotide variations,...
BackgroundXuanwei, a rural county, is located in the northeast of Yunnan Province, China. According to national retrospective survey on cancer mortality during 1973-1975, highest rate lung Xuanwei was 5.3 times higher than that areas nationwide. Age standardized rates (ASMR) were 23.14/105 and 4.34/105 China respectively. Characterization genomic alterations(GAs) drive patients (pts) disease development critical management. However, comprehensive features pts with non-small cell (NSCLC) have...
Objective To compare gene expression profiles between AFP negative and positive hepatocellular carcinoma (HCC). Methods The analysis of mRNA was performed on 20 samples HCC associated with HBV infection through Agilent® Whole Human Genome Oligo Microarray. Bioinformatics analyses were used to identify genes real time PCR applied verify microarray data. Results 352 differentially expressed in the two groups identified principal component analysis. 62 up-regulated found be...
Objective To explore the reference range of exhaled nitric oxide (FeNO) for healthy adults in Jinan city,Shandong province,provide diagnose and treatment chronic airway inflammation.Methods 200 (non-smoking,no history allergic diseases,no upper respiratory tract infection last two weeks,normal lung heart function testing,normal serum IgE) city were randomly selected.They divided into five groups by age (A group:16-19 years old,B group:20-29 old,C group:30-39 old,D group:40-59 old,and E...
Large language models (LLMs) are increasingly pivotal in a wide range of natural processing tasks. Access to pre-trained models, courtesy the open-source community, has made it possible adapt these specific applications for enhanced performance. However, substantial resources required training necessitate efficient solutions. This paper introduces CoLLiE, an library that facilitates collaborative large using 3D parallelism, parameter-efficient fine-tuning (PEFT) methods, and optimizers such...