A5104686220- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Viral Infections and Vectors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Congenital Anomalies and Fetal Surgery
- Nutrition, Genetics, and Disease
- Machine Learning in Bioinformatics
- Thermal Regulation in Medicine
- Circular RNAs in diseases
- Parasitic Infections and Diagnostics
- Parasitic infections in humans and animals
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Respiratory viral infections research
- Lung Cancer Treatments and Mutations
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
Guangxi Medical University
2020-2024
First Affiliated Hospital of GuangXi Medical University
2017-2024
Tumor Hospital of Guangxi Medical University
2017
Fudan University Shanghai Cancer Center
2013
Shanghai Medical College of Fudan University
2013
Lung cancer is still the leading cause of cancer-related death worldwide. Of lung cancer, adenocarcinoma (LUAD) most common subtype. Most patients with LUAD would develop into metastasis, which limits available treatment. Targeted therapy and immunotherapy provided options for those advanced patients. But they also broached up challenges to identify appropriate This study aims reveal landscapes genomic mutations in primary metastatic their actionability. enrolled 636 LUAD, whom 85 551 were...
MicroRNAs (miRs) have been demonstrated to be involved in the development and progression of osteosarcoma (OS), but molecular mechanism still remains fully investigated. The present study investigated function miR-148a OS, as well its underlying mechanism. Our data showed that was significantly downregulated OS tissues compared their matched adjacent normal tissues, also cell lines human osteoblast cells. Low expression associated with tumor a poor prognosis for patients. Rho-associated...
To investigate the impact of human herpes virus (
Abstract Introduction Alveolar echinococcosis (AE), caused by the larval forms of Echinococcus multilocularis , is a zoonotic disease affecting liver, lungs, lymph nodes, kidneys, brain, bones, thyroid, and other organs. Diagnosing AE in non-endemic area usually challenging. With rapid development increasing application sequencing techniques recent years, metagenomic next-generation (mNGS) has become powerful tool for diagnosing rare infectious diseases. Case Presentation A 45-year-old woman...
Abstract Background: Breast cancer is the most common malignancy in women worldwide and important therapeutic progress has been achieved over past decade. The identification of new biomarkers breast urgently needed to stratify populations who may benefit from personalized therapies. Defects homologous recombination DNA damage repair (HR-DDR) pathway sensitizes tumors therapeutics that target this pathway, such as (PARP) inhibitors. aim our study was determine prevalence HR-DDR pathogenic...
Abstract Background: Germline mutations in BRCA1, BRCA2 and other genes predispose to high risks of breast cancer. Genetic testing for germline BRCA1 has been widely used women with severe family history or ovarian cancer many western countries. However, China, hereditary associated their mutation types remain unclear. So far, there's no recommended guidelines high-risk populations. Next-Generation Sequencing (NGS) technology proved detect all classes cost-effectively. Here we describe the...