A5088655841- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Cancer survivorship and care
- Essential Oils and Antimicrobial Activity
- TGF-β signaling in diseases
- Nausea and vomiting management
- Microbial Natural Products and Biosynthesis
- Nanoparticles: synthesis and applications
- Plant and animal studies
- Oral health in cancer treatment
- Plant Molecular Biology Research
- Cancer Treatment and Pharmacology
First Affiliated Hospital of GuangXi Medical University
2019-2025
Guangxi Medical University
2019-2025
South China Agricultural University
2024
Central South University of Forestry and Technology
2022
Central South University
2022
Chinese Academy of Sciences
2013
Affiliated Hospital of Guilin Medical College
2013
The University of Texas at Austin
2013
Northeast Institute of Geography and Agroecology
2013
MAX2 (for MORE AXILLARY GROWTH2) has been shown to regulate diverse biological processes, including plant architecture, photomorphogenesis, senescence, and karrikin signaling. Although is a smoke-derived abiotic signal, role for in stress response pathways least investigated. Here, we show that the max2 mutant strongly hypersensitive drought compared with wild-type Arabidopsis (Arabidopsis thaliana). Stomatal closure of was less sensitive abscisic acid (ABA) than wild type. Cuticle thickness...
A smart in situ-formed wound dressing with excellent antibacterial ability against drug-resistance bacterial, antitumor, and biofilm-eliminating activities to promote effective closure is highly desirable therapeutic clinical applications. Herein, we designed developed a multifunctional; shape-adaptable; pH, temperature, near-infrared radiation (NIR) multiple responsive cellulose nanofibril (CNF)-based situ liquid dressing, using pH-sensitive CNF grafted terminated amino hyperbranched...
Postoperative infected wound complications caused by residual tumor cells, bacterial biofilms, and drug-resistant bacteria have become the main challenge in postsurgical skin regeneration. Herein, a bionic cellulose nanocrystal (CNC)-based situ intelligent dressing with near-infrared (NIR)-, temperature-, pH-responsive functions was designed using NIR-responsive CNC as network skeleton, dynamic imine bonds between dialdehyde nanocrystals doxorubicin, chitosan oligosaccharide switch,...
Primary pulmonary lymphoepithelial carcinoma (pLEC) is a subtype of non-small cell lung cancer (NSCLC) characterized by Epstein-Barr virus (EBV) infection. However, the molecular pathogenesis pLEC remains poorly understood. In this study, we explored using whole-exome sequencing (WES) and RNA-whole-transcriptome (RNA-seq) technologies. Datasets normal tissue, other types NSCLC, EBV-positive nasopharyngeal (EBV+-NPC) were obtained from public databases. Furthermore, described gene signatures,...
Clinical next-generation sequencing (NGS) tests have enabled treatment recommendations for cancer patients with driver gene mutations. Targeted therapy options without mutations are currently unavailable. Herein, we performed NGS and proteomics on 169 formalin-fixed paraffin-embedded (FFPE) samples of non-small cell lung cancers (NSCLC, 65), colorectal (CRC, 61), thyroid carcinomas (THCA, 14), gastric (GC, 2), gastrointestinal stromal tumors (GIST, 11), malignant melanomas (MM, 6). Of the...
Abstract Interfacing intelligent responsive molecules with biocompatible nanofibers is a promising strategy for developing overheated self‐managing photothermal dressings convenient and cost‐effective clinical applications. Here, an anisotropic staggered cellulose nanocage dressing properties constructed by temperature‐responsive flexible triblock copolymer Pluronic ® F‐127 interpenetrating smart nanofiber network skeleton, which interfaced white light (635 nm) protoporphyrin IX, NIR‐I (808...
Abstract Background Transforming growth factor (TGF)-β signaling functions importantly in regulating tumor microenvironment (TME). This study developed a prognostic gene signature based on TGF-β signaling-related genes for predicting clinical outcome of patients with lung adenocarcinoma (LUAD). Methods came from The Molecular Signature Database (MSigDB). LUAD prognosis-related were screened all the involved using least absolute shrinkage and selection operator (LASSO) Cox regression analysis...
Lung cancer is still the leading cause of cancer-related death worldwide. Of lung cancer, adenocarcinoma (LUAD) most common subtype. Most patients with LUAD would develop into metastasis, which limits available treatment. Targeted therapy and immunotherapy provided options for those advanced patients. But they also broached up challenges to identify appropriate This study aims reveal landscapes genomic mutations in primary metastatic their actionability. enrolled 636 LUAD, whom 85 551 were...
The interdisciplinary progress in nanotechnology has yielded environmentally friendly and cost-effective strategies to enhance bioherbicidal efficacy. This study presents the biosynthesis of silver nanoparticles (M-AgNPs) using fungus Exserohilum rostratum, specifically targeting Leptochloa chinensis weed paddy fields. M-AgNPs were characterized with an aqueous solution size 107.9 nm a zeta potential −24.0 ± 0.20 mV, their properties analyzed by UV-Vis spectrophotometry, transmission...
The function of miR-31-5p in lung squamous cell carcinoma (LUSC) remains unclear, therefore, a systematic study was performed for the clinical significance and molecular mechanism LUSC.Quantitative real-time reverse transcription PCR (qRT-PCR) utilized to test expression level 88 LUSC tissue samples their matching normal tissues. Data from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) were also confirm value LUSC. potential target genes predicted by several online software....
To develop optimal personalized therapy for lung adenocarcinoma (LUAD), potential biomarkers associated with the prognosis are urgently needed. It is unclear what role T Cell Leukemia Homeobox 1 (TLX1) plays in LUAD.
Abstract Background: Breast cancer is the most common malignancy in women worldwide and important therapeutic progress has been achieved over past decade. The identification of new biomarkers breast urgently needed to stratify populations who may benefit from personalized therapies. Defects homologous recombination DNA damage repair (HR-DDR) pathway sensitizes tumors therapeutics that target this pathway, such as (PARP) inhibitors. aim our study was determine prevalence HR-DDR pathogenic...