A5101443649- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Bone health and osteoporosis research
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Occupational and environmental lung diseases
- CNS Lymphoma Diagnosis and Treatment
- Forensic Anthropology and Bioarchaeology Studies
- Bone and Joint Diseases
- Tissue Engineering and Regenerative Medicine
- Helicobacter pylori-related gastroenterology studies
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
CM Hospital
2024
Zhejiang Chinese Medical University
2024
First Affiliated Hospital of Chengdu Medical College
2023
Chengdu Medical College
2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Second Hospital of Shandong University
2009-2022
Beijing Hua Xin Hospital
2017-2020
Abstract EGFR T790M mutation occurs in half of non-small cell lung cancer (NSCLC) patients with acquired EGFR-TKI (TKI) resistance, based on tumor re-biopsies using an invasive clinical procedure. Here, we dynamically monitored circulating DNA (ctDNA) serial plasma samples from NSCLC receiving TKI through Droplet Digital PCR (ddPCR) method and the associations between overall survival (OS) starting initial treatment ctDNA status detected were analyzed. Among 318 patients, 117 who resistance...
Crystalline silica has been classified as a human carcinogen by the International Agency for Research on Cancer (Lyon, France); however, few previous studies have provided quantitative data exposure, silicosis, and/or smoking. We investigated cohort in China (in 1960–2003) of 34,018 workers without exposure to carcinogenic confounders. Cumulative was estimated linking job-exposure matrix work history. Cox proportional hazards model used conduct exposure-response analysis and risk assessment....
// Xue Yang 1, * , Minglei Zhuo Xin Ye 2 Hua Bai 1 Zhijie Wang Yun Sun Jun Zhao Tongtong An Jianchun Duan Meina Wu Jie Department of Thoracic Medical Oncology, Key Laboratory Carcinogenesis and Translational Research (Ministry Education), Peking University Cancer Hospital Institute, Beijing, China Asia Emerging Markets Innovative Medicine AstraZeneca R & D, Shanghai, These authors contributed equally to this work Correspondence to: Wang, e-mail: zlhuxi@163.com Keywords: non-small-cell lung...
No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack quality evidence. This study aimed to describe practice variations therapies for early HTG-AP and assess whether more rapid triglyceride decline associated improving organ failure. a multicentre, prospective cohort recruiting elevated plasma (> 11.3 mmol/L) admitted within 72 h from onset symptoms. Patients were dichotomised on...
The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated. Therefore, we investigated the distribution somatic PIK3CA/AKT1 mutations and explored their roles tumor phenotypes disease prognosis.Tumors from 507 were prospectively collected West China Hospital between 2008 2013. Whole exons AKT1 PIK3CAwere detected freshfrozen tumors using next-generation sequencing, correlations clinicopathological features analyzed.The AKT1mutation was found 3.6% (18/507) patients....
Readiness for hospital discharge is an important indicator of patients' transition from illness to health and can predict rehabilitation prognosis. Identifying factors that influence readiness crucial developing effective nursing interventions. Therefore, this study aims investigate the current status its influencing in elderly patients with chronic obstructive pulmonary disease (COPD).A total 311 inpatients diagnosed COPD were enrolled investigation at a tertiary Chengdu between December...
Genomic profiling using plasma cell-free DNA (cfDNA) represents a non-invasive alternative to tumor re-biopsy, which is challenging in clinical practice. The feasibility of dynamically monitoring epidermal growth factor receptor (EGFR) mutation status serial samples from non-small cell lung cancer (NSCLC) patients treated by tyrosine kinase inhibitors (TKIs) and its application tracking response detection resistance were investigated.Forty-five NSCLC with EGFR mutation-positive pre-TKI at...
The prevalence of BRCA1/2 variants in Chinese breast cancer patients varies among studies. Germline or somatic mutations are associated with sensitivity to poly(ADP-ribose) polymerase-1 inhibitors and DNA-damaging agents. We aimed investigate the distribution both germline unselected patients, explore their roles tumor phenotype disease prognosis.507 for family history age at diagnosis, were prospectively enrolled from West China Hospital between Feb. 2008 2014. exons/flanking regions...
This study aimed to investigate changes in menstruation and the association of severity Omicron with after nationwide outbreak COVID-19 China. A cross-sectional adopted an electronic questionnaire conduct anonymous online survey. The survey targeted women reproductive age who had been infected SARS-CoV-2, were menstruating regularly six months prior infection, experienced at least one menstrual cycle infection. 737 included participants divided into mild severe groups based on Deviations...
The aim of the study was to investigate trastuzumab anti-tumor efficacy and its correlation with HER-2 status in primary xenograft models derived from Chinese patients gastric adenocarcinoma. Patient-derived adenocarcinoma (PDGAX) mouse were firstly generated by implanting tissues into immune deficient mice. A high degree histological molecular similarity between PDGAX their corresponding patients' shown pathological observation, expression, gene copy number, mutation detection. Based on...
9077 Background: Osimertinib is approved for metastatic NSCLC patients with EGFR T790M mutation after progression from EGFR-TKI therapy. Despite impressive tumor responses, drug resistance usually develops. Mechanisms of to osimertinib are emerging, while studies large cohorts Chinese still lacking. Here we reported a profile using plasma samples 76 who had progressed by DCO2 (Nov. 4, 2016) AURA17 study (NCT02442349), the pivotal trial China market approval. Methods: Serial cell-free DNA...
8081 Background: Prognosis for these patients with leptomeningeal metastasis (LM) is very poor due to the lack of therapeutic options. It was suggested that space protected from systemic chemotherapy as well EGFR-TKIs. Therefore, it would be interesting explore EGFR mutation status in CSF NSCLC who developed LM after initial response EGFR-TKI. In this study, we attempted address two questions: 1. what group patients? 2. difference compared concurrent plasma samples? Methods: A highly...