A5005335792- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Acute Ischemic Stroke Management
- Microtubule and mitosis dynamics
- Cancer Treatment and Pharmacology
- Immune cells in cancer
- Pancreatic function and diabetes
- PARP inhibition in cancer therapy
- Chronic Lymphocytic Leukemia Research
- Diabetes Treatment and Management
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Machine Learning in Healthcare
- Brain Metastases and Treatment
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
Shanghai University of Traditional Chinese Medicine
2025
Jilin Province Tumor Hospital
2018-2024
Shanghai Institute of Nutrition and Health
2023
University of Chinese Academy of Sciences
2023
The growing population of elderly neurocritically ill patients highlights the need for effective prognosis prediction tools. This study aims to develop and validate machine learning (ML) models predicting 28-day mortality in intensive care units (ICUs). Data were extracted from Medical Information Mart Intensive Care IV(MIMIC-IV) database, focusing on neurocritical with ICU stays ≥ 24 h. cohort was split into 70 % training 30 internal validation. We analyzed 58 variables, including...
Diabetic kidney disease (DKD), a leading cause of end-stage renal (ESRD), poses serious threat to global health. Aseptic inflammation and pyroptosis podocytes are crucial factors contributing the pathogenesis progression DKD. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), novel class antidiabetic agents widely used in clinical settings, may exert protective effect on podocyte injury, although underlying mechanisms remain poorly understood. This study uses streptozotocin (STZ) -induced...
BACKGROUND Intestinal barrier dysfunction is a prevalent and varied manifestation of acute pancreatitis (AP). Molecular mechanisms underlying the early intestinal in AP remain poorly understood. AIM To explore biological processes injury associated with AP, to find potential targets for prevention or treatment injury. METHODS This study utilized single-cell RNA sequencing small intestine, alongside vitro vivo experiments, examine function homeostasis during stages involved mechanisms....
BACKGROUND Hemorrhoids, a prevalent chronic condition globally, significantly impact patients' quality of life. While various surgical interventions, such as external stripping and internal ligation, procedure for prolapse hemorrhoids, tissue selecting technique, are employed treatment, they often associated with postoperative complications, including unsatisfactory defecation, bleeding, anal stenosis. In contrast, Xiaozhiling injection, traditional Chinese medicine-based therapy, has...
Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellular level. In order develop an SAP-targeting drug delivery system alleviate SAP level illustrate its mechanism, we explored the use of proanthocyanidin (PYD) pentoxifylline (PTX) loaded into macrophage membrane-coated self-assembly nanoparticles (FePTX@CM NPs) for targeted treatment. The...
Background: In the Phase III FLAURA study (NCT02296125), osimertinib showed superior efficacy compared with standard of care (SoC) EGFR-TKIs in patients (pts) previously untreated EGFRm advanced NSCLC. Here, we report preliminary data on mechanisms acquired resistance to pts who progressed during study. Methods: Pts (tissue, ex19del/L858R) NSCLC (N = 556) were randomised 1:1 80 mg once daily (QD; n 279) or SoC EGFR-TKI (n 277, gefitinib 250 QD erlotinib 150 QD). Paired plasma samples...
Background Cancer immunotherapies can induce durable tumor regression, but most patients do not respond. SETD2 mutation has been linked to the efficacy of immune checkpoint inhibitors (ICIs) immunotherapy. The functional importance inactivation and how modulate immunotherapy response remains unclear. Methods To explore function in immunotherapy, knockout subsequent experiments were conducted. Bulk RNA-seq, ATAC-seq, Chip-seq single-cell RNA-seq performed dissect mechanism microenvironment...
In the CameL phase III study (NCT03134872), Camre + Carbo-Pem was superior to for PFS in patients (pts) with previously untreated, advanced non-squamous NSCLC without EGFR/ALK alterations. Here, we present updated outcomes after a follow-up of approximately 5 yrs. Pts were randomized (1:1) and received 4–6 cycles (200 mg) plus (n=205) or (n=207) Q3W, followed by maintenance Pem only. Crossover from group monotherapy permitted disease progression. Total exposure up 2 As May 28, 2023, median...