A5065369551- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Parathyroid Disorders and Treatments
- Banana Cultivation and Research
- Cassava research and cyanide
- Mesenchymal stem cell research
- Genomics and Phylogenetic Studies
- Plant Gene Expression Analysis
- Plant responses to water stress
- Tissue Engineering and Regenerative Medicine
- Plant Micronutrient Interactions and Effects
- Plant nutrient uptake and metabolism
- Algal biology and biofuel production
- Connective tissue disorders research
- Genetic Syndromes and Imprinting
- Electrospun Nanofibers in Biomedical Applications
- Plant biochemistry and biosynthesis
- Plant Pathogens and Fungal Diseases
- Agricultural Productivity and Crop Improvement
- GDF15 and Related Biomarkers
- RNA Research and Splicing
- Soil and Environmental Studies
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
Chinese Academy of Tropical Agricultural Sciences
2021-2025
Coconut Research Institute
2025
Shanghai University of Traditional Chinese Medicine
2025
Jiangsu Province Hospital
2021-2024
Nanjing Medical University
2020-2024
Central Hospital of Putuo District
2024
Huazhong University of Science and Technology
2024
Institute of Scientific and Technical Information
2023
Sanya University
2023
Northeast Forestry University
2019-2022
Long non-coding RNAs (lncRNAs) are emerging as versatile regulators in diverse biological processes. However, little is known about their cis- and trans-regulatory contributions gene expression under salt stress. Using 27 RNA-seq data sets from Populus trichocarpa leaves, stems roots, we identified 2988 high-confidence lncRNAs, including 1183 salt-induced differentially expressed lncRNAs. Among them, 301 lncRNAs have potential for positively affecting neighboring genes, predominantly a...
Abstract Sleep, locomotor and social activities are essential animal behaviors, but their reciprocal relationships underlying mechanisms remain poorly understood. Here, we elicit information from a cutting-edge large-language model (LLM), generative pre-trained transformer (GPT) 3.5, which interprets 10.2–13.8% of Drosophila genes known to regulate the 3 behaviors. We develop an instrument for simultaneous video tracking multiple moving objects, conduct genome-wide screen. have identified...
Whole-genome duplication (WGD or polyploidization) has been suggested as a genetic contributor to angiosperm adaptation environmental changes. However, many eudicot lineages did not undergo recent WGD (R-WGD) around and/or after the Cretaceous-Paleogene (K-Pg) boundary, times of severe changes; how those plants survived largely ignored. Here, we collected 22 from major branches phylogeny and classified them into two groups according occurrence absence R-WGD: 12 R-WGD-containing (R-WGD-Y) 10...
The C-repeat binding factors/dehydration-responsive element protein 1s (CBFs/DREB1s) have been identified as major regulators of cold acclimation in many angiosperm plants. However, their origin and evolutionary process associated to responsiveness are still lacking. By integrating multi-omics data genomes, transcriptomes, CBFs/DREB1s genome-wide profiles, we unveil the evolution regulatory network. Gene collinearity phylogeny analyses show that CBF/DREB1 is an innovation evolved from tandem...
Puccinellia tenuiflora is the most saline-alkali tolerant plant in Songnen Plain, one of three largest soda lands worldwide. Here, we investigated physicochemical properties soils from Plain and sequenced transcriptomes germinated P. seedlings under long-term treatment (from seed soaking) with soil extracts.
Adverse environmental factors severely affect crop productivity. Improving resistance to multiple stressors is an important breeding goal. Although CBFs/DREB1s extensively participate in plant abiotic stress, the common mechanism underlying that mediate remains unclear. Here, we show for MaDREB1F conferring cold and drought stress banana. encodes a dehydration-responsive element binding protein (DREB) transcription factor with nuclear localization transcriptional activity. expression...
C-repeat binding factors (CBFs) are well-known transcription (TFs) that regulate plant cold acclimation. RNA sequencing (RNA-seq) data from diverse species provide opportunities to identify other TFs involved in the response. However, this task is challenging because gene gain and loss has led an intertwined community of co-orthologs in-paralogs between within species. Using orthogroup (closely related homologs) analysis, we identified 10,549 orthogroups five representative eudicots. A...
Abstract Background Metabolites play critical roles in regulating nutritional qualities of plants, thereby influencing their consumption and human health. However, the genetic basis underlying metabolite-based nutrient quality domestication root tuber crops remain largely unknown. Results We report a comprehensive study combining metabolic phenotypic genome-wide association studies to dissect metabolites storage (SR) cassava. quantify 2,980 features 299 cultivated cassava accessions. detect...
Increasing studies suggest that the biased retention of stress-related transcription factors (TFs) after whole-genome duplications (WGDs) could rewire gene transcriptional networks, facilitating plant adaptation to challenging environments. However, role posttranscriptional (e.g. RNA-binding proteins, RBPs) following WGDs has been largely ignored. Uncovering thousands RBPs in 21 representative angiosperm species, we integrate genomic, transcriptomic, regulatomic, and paleotemperature...
Vaccinium darrowii is a subtropical wild blueberry species that has been used to breed economically important southern highbush cultivars. The adaptive traits of V. climates can provide valuable information for breeding and perhaps other plants, especially against the background global warming. Here, we assembled genome into 12 pseudochromosomes using Oxford Nanopore long reads complemented with Hi-C scaffolding technologies, predicted 41 815 genes RNA-sequencing evidence. Syntenic analysis...
Diabetic kidney disease (DKD), a leading cause of end-stage renal (ESRD), poses serious threat to global health. Aseptic inflammation and pyroptosis podocytes are crucial factors contributing the pathogenesis progression DKD. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), novel class antidiabetic agents widely used in clinical settings, may exert protective effect on podocyte injury, although underlying mechanisms remain poorly understood. This study uses streptozotocin (STZ) -induced...
Introduction The Agatston coronary artery calcification score (CACS) is an assessment index for (CAC). This study aims to explore the characteristics of CAC in end-stage kidney disease (ESKD) patients and establish a predictive model assess risk severe patients.
Bicarbonate (NaHCO3) present in soils is usually considered to be a mixed stress for plants, with salts and high pH. NaHCO3-specific signaling plants has rarely been reported. In this study, transcriptome analyses were conducted order identify Arabidopsis. Weighted correlation network analysis was performed isolate modules comparison acetate treatment. The genes the NaHCO3-root-specific module, which exhibited opposite expression that sodium treatments, further examined their corresponding...
Serine/arginine-rich (SR) proteins are important splicing factors in plant development and abiotic/hormone-related stresses. However, evidence that SR contribute to the process woody plants has been lacking. Using phylogenetics, gene synteny, transgenic experiments, RNA-seq analysis, we identified 24 PtSR genes explored their evolution, expression, function Popolus trichocarpa. The were divided into six subfamilies, generated by at least two events of genome triplication duplication....
Phytohormone abscisic acid (ABA) influences the shelf life of fruit, vegetables, and tubers after harvest. However, little is known about core signaling module involved in ABA's control postharvest physiological process. Exogenous ABA alleviated deterioration (PPD) symptoms sliced cassava tuberous roots, increased endogenous levels, reduced H2O2 content. The specific during PPD process was identified as MePYL6-MePP2C16-MeSnRK2.1-MebZIP5/34. MebZIP5/MebZIP34 directly binds to activates...
Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality no proven therapy. Here, we reported severe uremic calciphylaxis patient progressive skin ischemia, large areas of painful malodorous ulcers, mummified legs. Because the worsening symptoms signs refractory to conventional therapies, treatment human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Preclinical release inspections hAMSCs, efficacy,...
Calciphylaxis is a rare cutaneous vascular disease that manifests with intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and microvessel thrombosis. Currently, there are no standardized guidelines for this disease. Recent studies have recognized high prevalence of thrombophilias hypercoagulable conditions in calciphylaxis patients. Here, we report case uremic patient whom was refractory to conventional treatments then...