A5100448202- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Pituitary Gland Disorders and Treatments
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Bioinformatics and Genomic Networks
- Glycosylation and Glycoproteins Research
- Peroxisome Proliferator-Activated Receptors
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
- Tuberous Sclerosis Complex Research
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
Xinqiao Hospital
2016-2025
Army Medical University
2016-2025
Henan University Huaihe Hospital and Huaihe Clinical Institute
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Peking University Shenzhen Hospital
2025
University of Hong Kong - Shenzhen Hospital
2025
University of Electronic Science and Technology of China
2025
Huazhong University of Science and Technology
2018-2024
Bengbu Medical College
2024
BRCA1 and BRCA2 mutations in general populations various types of cancers have not been well characterized. We investigated the presence these unselected patients with newly diagnosed incident ovarian cancer Ontario, Canada, respect to reported among their relatives.A population series 1171 between January 1, 1995, December 31, 1999, was screened for germline throughout genes. Screening involved testing common variants, then protein truncation long exons, denaturing gradient gel...
Abstract m 5 C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA maps at different stages development 6 vertebrate invertebrate species find convergent unexpected massive methylation maternal mediated by NSUN2 NSUN6. Using Drosophila as a model, reveal that embryos lacking undergo cell cycle delays fail to timely initiate maternal-to-zygotic transition, implying...
Abstract —The aim of this study was to elucidate the upstream signaling mechanism that mediates fluid shear stress activation mitogen-activated protein kinases (MAPKs), including c-Jun NH 2 -terminal kinase (JNK) and extracellular signal–regulated (ERKs), in vascular endothelial cells (ECs). Our results indicate p60src is rapidly activated by bovine aortic (BAECs). Shear induction hemagglutinin (HA) epitope–tagged HA-JNK1 Myc Myc-ERK2 significantly attenuated v-src(K295R) c-src(K295R),...
Deregulated production of IL-17 and IL-21 plays a key pathogenic role in many autoimmune disorders. A delineation the mechanisms that underlie inappropriate synthesis diseases can thus provide important insights into potential therapies for these Here we have shown serine-threonine kinase Rho-associated, coiled-coil-containing protein 2 (ROCK2) becomes activated mouse T cells under Th17 skewing conditions phosphorylates interferon regulatory factor 4 (IRF4), transcription is absolutely...
In Brief Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the pathogenesis of cancer pain still remain largely unknown. Previously, we have reported sensitization primary sensory dorsal root ganglion (DRG) neurons contributes to in rats. addition, numerous preclinical clinical studies revealed pathological roles interleukin-6 (IL-6) inflammatory neuropathic hyperalgesia. this study, investigated role IL-6...
Super-enhancers are large clusters of transcriptional enhancers regarded as having essential roles in driving the expression genes that control cell identity during development and tumorigenesis. The construction a genome-wide super-enhancer database is urgently needed to better understand super-enhancer-directed gene regulation for given biology process. Here, we present specifically designed web-accessible database, Super-Enhancer Archive (SEA, http://sea.edbc.org). SEA focuses on...
The combination of photothermal therapy (PTT) with gene (GT) to improve PTT efficiency and thus eliminate cancer cells under mild hyperthermia is highly needed. Herein, multifunctional WS2 @poly(ethylene imine) (WS2 @PEI) nanoplatform has been designed constructed for gene-photothermal synergistic tumors at condition. After a surface modification positively charged PEI, the as-prepared @PEI can not only act as an efficient survivin-siRNA carrier GT but also exhibit remarkable near-infrared...
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous subtype of that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it necessary investigate factors regulating progression develop novel therapies treatment. Ferroptosis, nonapoptotic form programmed cell death characterized by accumulation iron-dependent peroxidation phospholipids, regulated cellular metabolism, redox homeostasis, various cancer-related signaling...
Abstract Sleep, locomotor and social activities are essential animal behaviors, but their reciprocal relationships underlying mechanisms remain poorly understood. Here, we elicit information from a cutting-edge large-language model (LLM), generative pre-trained transformer (GPT) 3.5, which interprets 10.2–13.8% of Drosophila genes known to regulate the 3 behaviors. We develop an instrument for simultaneous video tracking multiple moving objects, conduct genome-wide screen. have identified...
Dear Editor, By taking advantage of parallel sequencing genome and transcriptome (G&T-seq),1 we demonstrated the distinct profiles human preimplantation blastocysts in perspectives embryo digital karyotype, developmental speed implantation competence. Our study provided valuable information for further research physiology behind development laid foundation selection from view transcriptome. Preimplantation genetic test aneuploidy (PGT-A) serves as an important invasive method to select...
The proliferation, differentiation, and protein synthesis of vascular smooth muscle cells (SMCs) play important roles in remodeling. Here, we compared the genetic programming signaling SMCs collagen matrix as a three-dimensional (3-D) environment on two-dimensional (2-D) surface. By using DNA microarrays with 9600 genes, showed that 77 genes were expressed more than twofold 22 less one-half 3-D matrix, when 2-D condition. higher expression level cyclin-dependent kinase inhibitor 1 (p21)...
Abstract Gastric cancer (GC) is a biologically heterogeneous disease accompanying various genetic and epigenetic alterations, the molecular mechanisms underlying this are complex not completely understood. Increasing evidence shows that abnormal microRNA (miRNA) expression involved in GC tumorigenesis, but role of specific miRNAs remains elusive. MiR-141 was previously reported to act as tumor suppressors or oncogenes diverse cancers. However, their accurate expression, function mechanism...
Abstract Autism spectrum disorder (ASD) affects 1–2% of all children and poses a great social economic challenge for the globe. As highly heterogeneous neurodevelopmental disorder, development its treatment is extremely challenging. Multiple pathways have been linked to pathogenesis ASD, including signaling involved in synaptic function, oxytocinergic activities, immune homeostasis, chromatin modifications, mitochondrial functions. Here, we identify secretagogin ( SCGN ), regulator...
Alterations in pathways mediated by retinoblastoma susceptibility gene ( RB ) product are among the most common human cancer. Mice with a single copy of Rb shown to develop syndrome multiple neuroendocrine neoplasia. The earliest Rb-deficient atypical cells were identified intermediate and anterior lobes pituitary, thyroid parathyroid glands, adrenal medulla within first 3 months postnatal development. These form gross tumors various degrees malignancy day 350. By age 380 days, 84% +/− mice...