Esther M. John
A5050097355- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Nutritional Studies and Diet
- Ovarian cancer diagnosis and treatment
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Photonic and Optical Devices
- CRISPR and Genetic Engineering
Stanford University
2016-2025
University of Toronto
2013-2024
Mount Sinai Hospital
2010-2024
Lunenfeld-Tanenbaum Research Institute
2014-2024
University of Manchester
2002-2024
Public Health Ontario
2014-2024
Palo Alto University
2016-2024
University of Otago
2017-2024
Ganga Hospital
2013-2024
Occupational Cancer Research Centre
2013-2024
<h3>Importance</h3> The clinical management of<i>BRCA1</i>and<i>BRCA2</i>mutation carriers requires accurate, prospective cancer risk estimates. <h3>Objectives</h3> To estimate age-specific risks of breast, ovarian, and contralateral breast for mutation to evaluate modification by family history location. <h3>Design, Setting, Participants</h3> Prospective cohort study 6036<i>BRCA1</i>and 3820<i>BRCA2</i>female (5046 unaffected 4810 with or ovarian both at baseline) recruited in 1997-2011...
Cross-talk between human epidermal growth factor receptors and hormone receptor pathways may cause endocrine resistance in breast cancer. This trial evaluated the effect of adding lapatinib, a dual tyrosine kinase inhibitor blocking 2 (HER2), to aromatase letrozole as first-line treatment (HR) -positive metastatic cancer (MBC).Postmenopausal women with HR-positive MBC were randomly assigned daily (2.5 mg orally) plus lapatinib (1,500 or placebo. The primary end point was progression-free...
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Concern with health effects of extremely low frequency magnetic fields has been raised by epidemiologic studies childhood cancer in relation to proximity electric power distribution lines. This case-control study was designed assess the between residential exposure and development cancer. Eligible cases consisted all 356 residents five-county 1970 Denver, Colorado Standard Metropolitan Statistical Area aged 0–14 years who were diagnosed any form 1976 1983. Controls selected random digit...
Journal Article Prostate Cancer in Relation to Diet, Physical Activity, and Body Size Blacks, Whites, Asians the United States Canada Get access Alice S. Whittemore, Whittemore 1Department of Health Research Policy, Stanford University School MedicineStanford, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Laurence N. Kolonel, Kolonel 2Cancer Center Hawaii, Hawaii at ManoaHonolulu Anna H. Wu, Wu 3Department Preventive Medicine, Southern CaliforniaLos...
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
BRCA1 and BRCA2 mutations in general populations various types of cancers have not been well characterized. We investigated the presence these unselected patients with newly diagnosed incident ovarian cancer Ontario, Canada, respect to reported among their relatives.A population series 1171 between January 1, 1995, December 31, 1999, was screened for germline throughout genes. Screening involved testing common variants, then protein truncation long exons, denaturing gradient gel...
A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because inheriting ancestry is greater men diagnosed before 72 years age (P < 0.00032) and may contribute the epidemiological observation that higher for greatest younger (and attenuates older age). same region was recently through linkage analysis cancer, followed by...
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
Abstract Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets mutation carriers should allow further tumor characterization. Methods: We used data from 4,325 2,568 to analyze the pathology invasive breast, ovarian, contralateral cancers. Results: There was strong evidence proportion estrogen receptor (ER)-negative decreased with age at diagnosis among (P-trend = 1.2 × 10−5), but increased BRCA2, 6.8 10−6)....
Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with 1,839 cancer), replication in an additional sample 2,646 carriers. We identified novel risk modifier locus at 1q32 for (rs2290854, P = 2.7×10−8, HR 1.14, 95% CI: 1.09–1.20). In addition, two loci: 17q21.31 (rs17631303, 1.4×10−8, 1.27, 1.17–1.38) 4q32.3 (rs4691139,...