Jianjun Liu

ORCID: 0000-0002-3255-3019
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About
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Research Areas
  • Genetic Associations and Epidemiology
  • Cancer-related molecular mechanisms research
  • BRCA gene mutations in cancer
  • RNA modifications and cancer
  • Epigenetics and DNA Methylation
  • Metabolomics and Mass Spectrometry Studies
  • Liver Disease Diagnosis and Treatment
  • Bioinformatics and Genomic Networks
  • Nutrition, Genetics, and Disease
  • Estrogen and related hormone effects
  • MicroRNA in disease regulation
  • Cancer, Hypoxia, and Metabolism
  • Genomics and Rare Diseases
  • Genetic and phenotypic traits in livestock
  • Circular RNAs in diseases
  • Particle physics theoretical and experimental studies
  • Genetic Mapping and Diversity in Plants and Animals
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Gene expression and cancer classification
  • Cancer Research and Treatments
  • Chronic Kidney Disease and Diabetes
  • Gastric Cancer Management and Outcomes
  • Wheat and Barley Genetics and Pathology
  • Genomic variations and chromosomal abnormalities

Genome Institute of Singapore
2016-2025

First Affiliated Hospital of Bengbu Medical College
2025

Agency for Science, Technology and Research
2016-2025

Tsinghua University
2006-2025

Xi'an High Tech University
2025

Chinese Pharmaceutical Association
2025

Shandong Academy of Agricultural Sciences
2016-2025

Huashan Hospital
2021-2025

Guangzhou Medical University
2024-2025

Tianjin Internal Combustion Engine Research Institute
2025

Douglas F. Easton Karen A. Pooley Alison M. Dunning Paul D.P. Pharoah Deborah J. Thompson and 95 more Dennis G. Ballinger Jeffery P. Struewing Jonathan J. Morrison Helen I. Field Robert Luben Nicholas J. Wareham Shahana Ahmed Catherine S. Healey Richard Bowman Craig Luccarini Don Conroy Mitul Shah Hannah Munday Clare Jordan Barbara Perkins Judy West Karen Redman Kristy Driver Kerstin B. Meyer Christopher A. Haiman Laurence Kolonel Brian E. Henderson Loı̈c Le Marchand Paul Brennan Suleeporn Sangrajrang Valérie Gaborieau Fabrice Odefrey Chen‐Yang Shen Pei‐Ei Wu Hui‐Chun Wang Diana Eccles D. Gareth Evans Julian Peto Olivia Fletcher Nichola Johnson Sheila Seal Michael R. Stratton Nazneen Rahman Georgia Chenevix‐Trench Stig E. Bojesen Børge G. Nordestgaard C. K. Axelsson Montserrat García‐Closas Louise A. Brinton Stephen J. Chanock Jolanta Lissowska Beata Pepłońska Heli Nevanlinna Rainer Fagerholm Hannaleena Eerola Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei Hyun Ahn David J. Hunter Susan E. Hankinson David G. Cox Per Hall Sara Wedrén Jianjun Liu Yen-Ling Low Natalia Bogdanova Peter Schürmann Thilo Dörk Rob A.�E.�M. Tollenaar Catharina E. Jacobi Peter Devilee Jan G.M. Klijn Alice J. Sigurdson Michele M. Doody Bruce H. Alexander Jinghui Zhang Angela Cox Ian W. Brock Gordon R. Macpherson Malcolm Reed Fergus J. Couch Ellen L. Goode Janet E. Olson Hanne Meijers‐Heijboer Ans van den Ouweland André G. Uitterlinden Fernando Rivadeneira Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez John L. Hopper Margaret McCredie Melissa C. Southey Graham G. Giles Chris Schroen Christina Justenhoven Hiltrud Brauch Ute Hamann

10.1038/nature05887 article EN Nature 2007-05-27
Kyriaki Michailidou Per Hall Anna González‐Neira Maya Ghoussaini Joe Dennis and 95 more Roger L. Milne Marjanka K. Schmidt Jenny Chang‐Claude Stig E. Bojesen Manjeet K. Bolla Qin Wang Ed Dicks Andrew Lee Clare Turnbull Nazneen Rahman Olivia Fletcher Julian Peto Lorna J. Gibson Isabel dos‐Santos‐Silva Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Kamila Czene Astrid Irwanto Jianjun Liu Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Rebecca Hein Norbert Dahmen L. Beckman Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner John L. Hopper Melissa C. Southey Enes Makalic Daniel F. Schmidt André G. Uitterlinden Albert Hofman David J. Hunter Stephen J. Chanock Daniel Vincent François Bacot Daniel C. Tessier Sander Canisius Lodewyk F.A. Wessels Christopher A. Haiman Mitul Shah Robert Luben Judith Brown Craig Luccarini Nils Schoof Keith Humphreys Jingmei Li Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Fergus J. Couch Xianshu Wang Celine M. Vachon Kristen N. Stevens Diether Lambrechts Matthieu Moisse Robert Paridaens Marie‐Rose Christiaens Anja Rudolph Stefan Nickels Dieter Flesch‐Janys Nichola Johnson Zoe Aitken Kirsimari Aaltonen Tuomas Heikkinen Annegien Broeks Laura J. van’t Veer C. Ellen van der Schoot Pascal Guénel Thérèse Truong Pierre Laurent–Puig F. Ménégaux Frederik Marmé Andreas Schneeweiß Christof Sohn Barbara Burwinkel M. Pilar Zamora José Ignacio Arias Pérez Guillermo Pita M. Rosario Alonso Angela Cox Ian W. Brock Simon S. Cross Malcolm Reed Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Brian E. Henderson

10.1038/ng.2563 article EN Nature Genetics 2013-03-27

The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on biologic understanding leprosy. Host genetic factors are thought influence susceptibility infection as well disease progression.We performed a two-stage genomewide association study by genotyping 706 patients 1225 controls using Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an between presence leprosy 93 single-nucleotide...

10.1056/nejmoa0903753 article EN New England Journal of Medicine 2009-12-18

Background Mild retinopathy (microaneurysms or dot-blot hemorrhages) is observed in persons without diabetes hypertension and may reflect microvascular disease other organs. We conducted a genome-wide association study (GWAS) of mild diabetes. Methods A working group agreed on phenotype harmonization, covariate selection analytic plans for within-cohort GWAS. An inverse-variance weighted fixed effects meta-analysis was performed with GWAS results from six cohorts 19,411 Caucasians. The...

10.1371/journal.pone.0054232 article EN cc-by PLoS ONE 2013-02-05

Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that critical for intestinal cholesterol absorption. The uptake of phytosterols and into absorptive the intestine not fully defined on molecular level, role NPC1L1 maintaining whole body homeostasis known. null mice had substantially reduced sitosterol, with dramatically plasma phytosterol levels. were completely resistant to diet-induced hypercholesterolemia, lipoprotein hepatic profiles similar those wild type...

10.1074/jbc.m405817200 article EN cc-by Journal of Biological Chemistry 2004-06-08
Xiaohong R. Yang Jenny Chang‐Claude Ellen L. Goode Fergus J. Couch Heli Nevanlinna and 95 more Roger L. Milne Mia M. Gaudet Marjanka K. Schmidt Annegien Broeks Angela Cox Peter A. Fasching Rebecca Hein Amanda B. Spurdle Fiona M. Blows Kristy Driver Dieter Flesch‐Janys Judith Heinz Hans‐Peter Sinn Alina Vrieling Tuomas Heikkinen Kristiina Aittomäki Päivi Heikkilä Carl Blomqvist Jolanta Lissowska Beata Pepłońska Stephen J. Chanock Jonine D. Figueroa Louise A. Brinton Per Hall Kamila Czene Keith Humphreys Hatef Darabi Jianjun Liu Laura van ‘t Veer Flora E. van Leeuwen Irene L. Andrulis Gord Glendon Julia A. Knight Anna Marie Mulligan Frances P. O’Malley Nayana Weerasooriya Esther M. John Matthias W. Beckmann Arndt Hartmann Sebastian Weihbrecht David L. Wachter Sebastian M. Jud Christian R. Loehberg Laura Baglietto Dallas R. English Graham G. Giles Catriona McLean Gianluca Severi Diether Lambrechts T. Vandorpe Caroline Weltens Robert Paridaens Ann Smeets Patrick Neven Hans Wildiers Xianshu Wang Janet E. Olson Victoria Cafourek Zachary Fredericksen Matthew Kosel Celine M. Vachon Helen Cramp Daniel Connley Simon S. Cross Sabapathy P. Balasubramanian Malcolm Reed Thilo Dörk Michael Bremer Andreas Meyer Johann H. Karstens Aysun Ay Tjoung‐Won Park‐Simon Peter Hillemanns José Ignacio Arias Pérez Primitiva Menéndez Rodríguez Pilar Zamora Javier Benı́tez Yon‐Dschun Ko Hans‐Peter Fischer Ute Hamann Beate Pesch Thomas Brüning Christina Justenhoven Hiltrud Brauch Diana Eccles William Tapper Sue Gerty Elinor J. Sawyer Ian Tomlinson Angela Jones Michael J. Kerin Nicola Miller Niall McInerney Hoda Anton‐Culver Argyrios Ziogas

Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.

10.1093/jnci/djq526 article EN JNCI Journal of the National Cancer Institute 2010-12-29
Sofia Khan Dario Greco Kyriaki Michailidou Roger L. Milne Taru Muranen and 95 more Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K. Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang‐Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch‐Janys Olivia Fletcher Julian Peto Isabel dos‐Santos‐Silva Nichola Johnson Lorna J. Gibson Zoe Aitken John L. Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F. Schmidt Melissa C. Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J. Chanock David J. Hunter Angela Cox Simon S. Cross Malcolm Reed Marjanka K. Schmidt Annegien Broeks Laura J. V. a. n't. Veer Frans B.L. Hogervorst Peter A. Fasching Michael Schrauder Arif B. Ekici Matthias W. Beckmann Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Javier Benı́tez Pilar Zamora José Ignacio Arias Pérez Christopher A. Haiman Brian E. Henderson Fredrick R. Schumacher Loı̈c Le Marchand Paul D.P. Pharoah Alison M. Dunning Mitul Shah Robert Luben Judith Brown Fergus J. Couch Xianshu Wang Celine M. Vachon Janet E. Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent–Puig Claire Mulot F. Marmé Barbara Burwinkel Andreas Schneeweiß Christof Sohn Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Irene L. Andrulis Julia A. Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia Bogdanova Natalia Antonenkova

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...

10.1371/journal.pone.0109973 article EN cc-by PLoS ONE 2014-11-12

10.1038/ng1981 article EN Nature Genetics 2007-02-11
Nasim Mavaddat Paul D.P. Pharoah Kyriaki Michailidou Jonathan P. Tyrer Mark N. Brook and 95 more Manjeet K. Bolla Qin Wang Joe Dennis Alison M. Dunning Mitul Shah Robert Luben Judith Brown Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Kamila Czene Hatef Darabi Mikael Eriksson Julian Peto Isabel dos‐Santos‐Silva Frank Dudbridge Nichola Johnson Marjanka K. Schmidt Annegien Broeks Senno Verhoef Emiel J. Rutgers Anthony J. Swerdlow Alan Ashworth Nick Orr Minouk J. Schoemaker Jonine D. Figueroa Stephen J. Chanock Louise A. Brinton Jolanta Lissowska Fergus J. Couch Janet E. Olson Celine M. Vachon V. Shane Pankratz Diether Lambrechts Hans Wildiers Chantal Van Ongeval Erik Van Limbergen Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne‐Lise Børresen‐Dale Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Jenny Chang‐Claude Anja Rudolph Petra Seibold Dieter Flesch‐Janys Peter A. Fasching Lothar Haeberle Arif B. Ekici Matthias W. Beckmann Barbara Burwinkel Frederik Marmé Andreas Schneeweiß Christof Sohn Amy Trentham‐Dietz Polly A. Newcomb Linda Titus Kathleen M. Egan David J. Hunter Sara Lindström Rulla M. Tamimi Peter Kraft Nazneen Rahman Clare Turnbull Anthony Renwick Sheila Seal Jingmei Li Jianjun Liu Keith Humphreys Javier Benı́tez M. Pilar Zamora José Ignacio Arias Pérez Primitiva Menéndez Anna Jakubowska Jan Lubiński Katarzyna Jaworska–Bieniek Katarzyna Durda Natalia Bogdanova Natalia Antonenkova Thilo Dörk Hoda Anton‐Culver Susan L. Neuhausen Argyrios Ziogas Leslie Bernstein Peter Devilee Robert A.E.M. Tollenaar Caroline Seynaeve Christi J. van Asperen Angela Cox Simon S. Cross Malcolm Reed

Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...

10.1093/jnci/djv036 article EN cc-by JNCI Journal of the National Cancer Institute 2015-04-02

A lead-free high-Curie-point Aurivillius-phase ferroelectric ceramic, CaBi2Nb2O9, has been fabricated by spark plasma sintering (SPS). It a Curie point (943 °C) that is much higher than previously reported (650 °C). The piezoelectric constant d33 of the SPS textured material was nearly three times ordinary-fired (OF) materials and stable up to 800 °C (see Figure). These ceramics are promising candidates for high- temperature applications.

10.1002/adma.200401860 article EN Advanced Materials 2005-05-03
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