Paul Brennan

ORCID: 0000-0002-0518-8714
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About
Contact & Profiles
Research Areas
  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Head and Neck Cancer Studies
  • Cancer Genomics and Diagnostics
  • RNA modifications and cancer
  • Liver Disease Diagnosis and Treatment
  • Renal cell carcinoma treatment
  • Cancer-related molecular mechanisms research
  • BRCA gene mutations in cancer
  • Lung Cancer Treatments and Mutations
  • Nutritional Studies and Diet
  • Pancreatic and Hepatic Oncology Research
  • Folate and B Vitamins Research
  • Lymphoma Diagnosis and Treatment
  • Genetic factors in colorectal cancer
  • Esophageal Cancer Research and Treatment
  • Cancer, Lipids, and Metabolism
  • Nutrition, Genetics, and Disease
  • Glutathione Transferases and Polymorphisms
  • Endoplasmic Reticulum Stress and Disease
  • Cancer Risks and Factors
  • Cervical Cancer and HPV Research
  • Alcohol Consumption and Health Effects
  • Renal and related cancers
  • Smoking Behavior and Cessation

Centre International de Recherche sur le Cancer
2016-2025

Newcastle University
2012-2024

Université Laval
2024

Centre for Life
2022-2024

Newcastle upon Tyne Hospitals NHS Foundation Trust
2020-2024

Institut Universitaire de Cardiologie et de Pneumologie de Québec
2024

AC Camargo Hospital
2024

Ludwig-Maximilians-Universität München
2023

Norwegian Institute of Public Health
2011-2023

University of Bergen
2011-2023

Kyriaki Michailidou Sara Lindström Joe Dennis Jonathan Beesley Shirley Hui and 95 more Siddhartha Kar Audrey Lemaçon Penny Soucy Dylan M. Glubb Asha Rostamianfar Manjeet K. Bolla Qin Wang Jonathan P. Tyrer Ed Dicks Andrew Lee Zhaoming Wang Jamie Allen Renske Keeman Ursula Eilber Juliet D. French Xiaohong Chen Laura Fachal Karen McCue Amy E. McCart Reed Maya Ghoussaini Jason S. Carroll Xia Jiang Hilary K. Finucane Marcia Adams Muriel A. Adank Habibul Ahsan Kristiina Aittomäki Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Banu K. Arun Paul L. Auer François Bacot Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Paul Brennan Hermann Brenner Louise A. Brinton Per Broberg Ian W. Brock Annegien Broeks Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Katja Butterbach Qiuyin Cai Hui Cai Trinidad Caldés Federico Canzian Ángel Carracedo Brian D. Carter Jose E. Castelao Tsun Leung Chan Ting‐Yuan David Cheng Kee Seng Chia Ji‐Yeob Choi Hans Christiansen Christine L. Clarke Margriet Collée Don Conroy Emilie Cordina‐Duverger Sten Cornelissen David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Mingajeva Elvira Christoph Engel

10.1038/nature24284 article EN Nature 2017-10-20

Abstract Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on head neck cancers is not clear because studies have used various methods to quantify excess cancer burden. Methods: We analyzed individual-level pooled data from 17 European American case-control (11,221 cases 16,168 controls) participating in International Head Neck Cancer Epidemiology consortium. estimated multiplicative parameter (ψ) population attributable risks (PAR). Results: A...

10.1158/1055-9965.epi-08-0347 article EN Cancer Epidemiology Biomarkers & Prevention 2009-02-01

Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...

10.1371/journal.pone.0177875 article EN public-domain PLoS ONE 2017-06-08

10.1038/ng1981 article EN Nature Genetics 2007-02-11

Abstract Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation the von Hippel-Lindau (VHL) gene in cancer genome, unique to clear cell renal (ccRCC). Identify relationships between prevalence VHL alterations alteration subtypes with patient tumor characteristics. Experimental Design: As part large kidney case-control study conducted Central Europe, we analyzed mutations methylation 205 well-characterized, histologically confirmed biopsies...

10.1158/1078-0432.ccr-07-4921 article EN Clinical Cancer Research 2008-08-01
Nathaniel Rothman Montserrat García‐Closas Nilanjan Chatterjee Núria Malats Xifeng Wu and 95 more Jonine D. Figueroa Francisco X. Real David Van Den Berg Giuseppe Matullo Dalsu Baris Michael J. Thun Lambertus A. Kiemeney Paolo Vineis Immaculata De Vivo Demetrius Albanes Mark P. Purdue Þórunn Rafnar Michelle A.T. Hildebrandt Anne E. Kiltie Olivier Cussenot Klaus Golka Rajiv Kumar Jack A. Taylor José Mayordomo Kevin B. Jacobs Manolis Kogevinas Amy Hutchinson Zhaoming Wang Yi‐Ping Fu Ludmila Prokunina‐Olsson Laurie Burdett Meredith Yeager William Wheeler Adonina Tardón Consol Serra Alfredo Carrato Reina García-Closas Josep Lloreta Alison Johnson Molly Schwenn Margaret R. Karagas Alan R. Schned Gerald L. Andriole Robert L. Grubb Amanda Black Eric J. Jacobs W. Ryan Diver Susan M. Gapstur Stephanie J. Weinstein Jarmo Virtamo Victoria K. Cortessis Manuela Gago‐Dominguez Malcolm C. Pike Mariana C. Stern Jian‐Min Yuan David J. Hunter Monica McGrath Colin P. Dinney Bogdan Czerniak Meng Chen Hushan Yang Sita H. Vermeulen Katja K.H. Aben J.A. Witjes Remco R. Makkinje Patrick Sulem Søren Besenbacher Kári Stéfansson Elio Ríboli Paul Brennan Salvatore Panico Carmen Navarro Naomi E. Allen H. Bas Bueno-de-Mesquita Dimitrios Trichopoulos Neil E. Caporaso Maria Teresa Landi Federico Canzian Börje Ljungberg Anne Tjønneland Françoise Clavel‐Chapelon D. Timothy Bishop Mark Teo Margaret A. Knowles Simonetta Guarrera Silvia Polidoro Fulvio Ricceri Carlotta Sacerdote Alessandra Allione Géraldine Cancel‐Tassin Silvia Selinski Jan G. Hengstler H. Dietrich Tony Fletcher Péter Rudnai Eugen Gurzău Kvetoslava Koppová Sophia C.E. Bolick Ashley C. Godfrey Zongli Xu

10.1038/ng.687 article EN Nature Genetics 2010-10-24

Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung remain inconclusive. By using one largest datasets ever assembled, we explored impact on risks major cell types cancer. This pooled analysis included 13,169 cases 16,010 controls from Europe Canada. Studies with population comprised 66.5% subjects. Adenocarcinoma (AdCa) was most prevalent subtype in never smokers women. Squamous carcinoma (SqCC) predominated male smokers....

10.1002/ijc.27339 article EN International Journal of Cancer 2011-11-02
Philip Haycock Stephen Burgess Aayah Nounu Jie Zheng George N. Okoli and 95 more Jack Bowden Kaitlin H. Wade Nicholas J. Timpson David M. Evans Peter Willeit Abraham Aviv Tom R. Gaunt Gibran Hemani Massimo Mangino Hayley Ellis Kathreena M. Kurian Karen A. Pooley Rosalind A. Eeles Jeffrey E. Lee Shenying Fang Wei V. Chen Matthew H. Law Lisa Bowdler Mark M. Iles Qiong Yang Bradford B. Worrall Hugh S. Markus Rayjean J. Hung Chris Amos Amanda B. Spurdle Deborah J. Thompson Tracy A. O’Mara Brian M. Wolpin Laufey T. Ámundadóttir Rachael Z. Stolzenberg‐Solomon Antonia Trichopoulou N. Charlotte Onland‐Moret Eiliv Lund Eric J. Duell Federico Canzian Gianluca Severi Kim Overvad Marc J. Gunter ­Rosario ­Tumino Ulrika Svenson André van Rij Annette F. Baas Matthew J. Bown Nilesh J. Samani Femke N.G. van t’Hof Gerard Tromp Gregory T. Jones Helena Kuivaniemi James R. Elmore Mattias Johansson James McKay Ghislaine Scélo Robert Carreras‐Torres Valérie Gaborieau Paul Brennan Paige M. Bracci Rachel Ε. Neale Sara H. Olson Steven Gallinger Donghui Li Gloria M. Petersen Harvey A. Risch Alison P. Klein Jiali Han Christian C. Abnet Neal D. Freedman Philip R. Taylor John M. Maris Katja K.H. Aben Lambertus A. Kiemeney Sita H. Vermeulen John K. Wiencke Kyle M. Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R. Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew‐Kee Low Krina T. Zondervan Grant W. Montgomery Dale R. Nyholt David A. van Heel Karen A. Hunt Dan E. Arking Foram N. Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand

The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.

10.1001/jamaoncol.2016.5945 article EN JAMA Oncology 2017-02-27
Ernest Turro William J. Astle Karyn Mégy Stefan Gräf Daniel Greene and 95 more Olga Shamardina Hana Lango Allen Alba Sanchis‐Juan Mattia Frontini Chantal Thys Jonathan Stephens Rutendo Mapeta Oliver S. Burren Kate Downes Matthias Haimel Salih Tuna Sri V. V. Deevi Timothy J. Aitman David Bennett Paul Calleja Keren Carss Mark J. Caulfield Patrick F. Chinnery Peter H. Dixon Daniel P. Gale Roger James Ania Koziell Michael Laffan Adam P. Levine Eamonn R. Maher Hugh S. Markus Joannella Morales Nicholas W. Morrell Andrew Mumford Elizabeth Ormondroyd Stuart Rankin Augusto Rendon Sylvia Richardson Irene Roberts Noémi Roy Moin A. Saleem Kenneth G. C. Smith Hannah Stark Rhea Tan Andreas C. Themistocleous Adrian J. Thrasher Hugh Watkins Andrew R. Webster Martin R. Wilkins Catherine Williamson James Whitworth Sean Humphray David Bentley Stephen Abbs Lara Abulhoul Julian Adlard Munaza Ahmed Timothy J. Aitman Hana Alachkar David Allsup J. P. Almeida Philip Ancliff Richard Antrobus Ruth Armstrong Gavin Arno Sofie Ashford William J. Astle Anthony Attwood Paul Aurora Christian Babbs Chiara Bacchelli Tamam Bakchoul Siddharth Banka Tadbir K. Bariana Julian Barwell Joana Batista Helen Baxendale Phil Beales David Bennett David Bentley Agnieszka Bierżyńska Tina Biss Maria Bitner‐Glindzicz Graeme Black Marta Bleda Iulia Blesneac Detlef Böckenhauer Harm Jan Bogaard Christian Bourne Sara Boyce John R. Bradley Eugene Bragin Gerome Breen Paul Brennan Carole Brewer Matthew A. Brown Andrew C. Browning Michael J. Browning Rachel Buchan Matthew Buckland

10.1038/s41586-020-2434-2 article EN Nature 2020-06-24

10.1038/ng.3002 article EN Nature Genetics 2014-06-01

Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on were ascertained part two multicenter case-control studies comprising 924 cases 928 controls central Europe 2,286 1,824 Latin America. Incident squamous cell carcinoma (oral cavity, pharynx, larynx) esophagus, well age (in quinquennia)- sex frequency-matched controls, enrolled from 1998 to 2003. condition mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81;...

10.1093/aje/kwm193 article EN American Journal of Epidemiology 2007-08-30
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