Paul Brennan
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- Folate and B Vitamins Research
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Glutathione Transferases and Polymorphisms
- Endoplasmic Reticulum Stress and Disease
- Cancer Risks and Factors
- Cervical Cancer and HPV Research
- Alcohol Consumption and Health Effects
- Renal and related cancers
- Smoking Behavior and Cessation
Centre International de Recherche sur le Cancer
2016-2025
Newcastle University
2012-2024
Université Laval
2024
Centre for Life
2022-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020-2024
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2024
AC Camargo Hospital
2024
Ludwig-Maximilians-Universität München
2023
Norwegian Institute of Public Health
2011-2023
University of Bergen
2011-2023
Abstract Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on head neck cancers is not clear because studies have used various methods to quantify excess cancer burden. Methods: We analyzed individual-level pooled data from 17 European American case-control (11,221 cases 16,168 controls) participating in International Head Neck Cancer Epidemiology consortium. estimated multiplicative parameter (ψ) population attributable risks (PAR). Results: A...
Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...
Abstract Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation the von Hippel-Lindau (VHL) gene in cancer genome, unique to clear cell renal (ccRCC). Identify relationships between prevalence VHL alterations alteration subtypes with patient tumor characteristics. Experimental Design: As part large kidney case-control study conducted Central Europe, we analyzed mutations methylation 205 well-characterized, histologically confirmed biopsies...
Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung remain inconclusive. By using one largest datasets ever assembled, we explored impact on risks major cell types cancer. This pooled analysis included 13,169 cases 16,010 controls from Europe Canada. Studies with population comprised 66.5% subjects. Adenocarcinoma (AdCa) was most prevalent subtype in never smokers women. Squamous carcinoma (SqCC) predominated male smokers....
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on were ascertained part two multicenter case-control studies comprising 924 cases 928 controls central Europe 2,286 1,824 Latin America. Incident squamous cell carcinoma (oral cavity, pharynx, larynx) esophagus, well age (in quinquennia)- sex frequency-matched controls, enrolled from 1998 to 2003. condition mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81;...