N. Charlotte Onland‐Moret
A5040046813- Ovarian cancer diagnosis and treatment
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Nutritional Studies and Diet
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Ovarian function and disorders
- Menopause: Health Impacts and Treatments
- Lipoproteins and Cardiovascular Health
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Function and Risk Factors
- Obesity, Physical Activity, Diet
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Health, Environment, Cognitive Aging
- Reproductive Biology and Fertility
- Diet and metabolism studies
- Hormonal and reproductive studies
- Endometriosis Research and Treatment
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
University Medical Center Utrecht
2016-2025
Utrecht University
2016-2025
Cancer Research UK
2005-2023
Leidsche Rijn Julius Health Centers
2017-2023
Oklahoma State University Center for Health Sciences
2004-2023
MRC Biostatistics Unit
2021-2023
University of Cambridge
2021-2023
Health Data Research UK
2021-2023
British Heart Foundation
2021-2023
Medical Research Council
2021-2023
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
An understanding of the etiologic heterogeneity ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, lifestyle factors by histologic subtype in Ovarian Cancer Cohort Consortium (OC3).
Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, both an or lack adrenal androgens (dehydroepiandrosterone [DHEA] its sulfate [DHEAS]) as risk factors. We conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition cohort to examine associations serum concentrations subsequent...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Endometrial cancer risk has been associated with reproductive factors (age at menarche, age menopause, parity, first and last birth, time since birth use of oral contraceptives (OCs)]. However, these are closely interrelated whether they act independently still requires clarification. We conducted a study to examine the association menstrual variables endometrial among European Prospective Investigation into Cancer Nutrition (EPIC). Among 302,618 women eligible for study, 1,017 incident...
BackgroundRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability results to individuals with low status is unclear. We aimed characterise dose-response relationships between 25-hydroxyvitamin (25[OH]D) concentrations risk coronary heart disease, stroke, in observational Mendelian randomisation frameworks.MethodsObservational analyses were undertaken using data from 33 prospective...
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform genome-wide meta-analysis LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 regions at false dicovery rate (FDR) < 0.05 threshold prioritize genes 31, with five highlighting nucleotide metabolism as an important regulator LTL. report six significant loci in or near SENP7, MOB1B,...
Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little on association with endogenous sex hormone levels. We analyzed between prediagnostic serum concentrations steroids cancer risk European Prospective Investigation into Cancer Nutrition using a nested case–control design 247 incident cases 481 controls, matched center, menopausal status, age, variables relating to blood collection, and, for premenopausal...
In the last two centuries, age at menarche has decreased in several European populations, whereas adult height increased. It is unclear whether these trends have ceased recent years or how and are related individuals. this study, authors first investigated among 286,205 women from nine countries by computing mean 5-year birth cohorts, adjusted for differences socioeconomic status. Second, relation between was estimated linear regression models, enrollment 1992 1998 Mean 44 days per cohort...
OBJECTIVE Age at menopause is an important determinant of future health outcomes, but little known about its relationship with type 2 diabetes. We examined the associations menopausal age and reproductive life span (menopausal minus menarcheal age) diabetes risk. RESEARCH DESIGN AND METHODS Data were obtained from InterAct study, a prospective case-cohort study nested within European Prospective Investigation into Cancer Nutrition. A total 3,691 postmenopausal diabetic case subjects 4,408...
It is well established that parity and use of oral contraceptives reduce the risk ovarian cancer, but associations with other reproductive variables are less clear. We examined contraceptive factors cancer in European Prospective Investigation into Cancer Nutrition. Among 327 396 eligible women, 878 developed over an average 9 years. Hazard ratios (HRs) 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre age, adjusted for smoking status,...
Several genome-wide association studies (GWAS) have been published on various complex diseases. Although, new loci are found to be associated with these diseases, still only very little of the genetic risk for diseases can explained. As GWAS underpowered find small main effects, and gene-gene interactions likely play a role, data might currently not analyzed its full potential. In this study, we evaluated alternative methods study data. Instead focusing single nucleotide polymorphisms (SNPs)...