Lavinia Paternoster
A5071914597- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Bone health and osteoporosis research
- Genetic Mapping and Diversity in Plants and Animals
- Health, Environment, Cognitive Aging
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Bioinformatics and Genomic Networks
- Growth Hormone and Insulin-like Growth Factors
- Gestational Diabetes Research and Management
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Psoriasis: Treatment and Pathogenesis
- Pregnancy and preeclampsia studies
- Genetics and Neurodevelopmental Disorders
- Genetics and Physical Performance
- Bone Metabolism and Diseases
- Food Allergy and Anaphylaxis Research
- Vitamin D Research Studies
University of Bristol
2015-2024
Medical Research Council
2012-2024
MRC Epidemiology Unit
2015-2024
University Hospitals Bristol NHS Foundation Trust
2024
NIHR Bristol Biomedical Research Centre
2024
University Hospitals Bristol and Weston NHS Foundation Trust
2024
At Bristol
2024
MRC Integrative Epidemiology Unit
2018-2023
University of Aberdeen
2019
Universitat de les Illes Balears
2019
LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability complex traits diseases, partition this into functional categories, genetic correlation between different phenotypes. Because relies on summary level data, computationally tractable even for very large sample sizes. However, publicly available GWAS are typically stored in databases have formats, making it difficult apply correlations...
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
Abstract Large studies use genotype data to discover genetic contributions complex traits and infer relationships between those traits. Co-incident geographical variation in genotypes health can bias these analyses. Here we show that single variants scores composed of multiple are associated with birth location within UK Biobank geographic structure cannot be accounted for using routine adjustment study centre principal components derived from data. We find major outcomes appear...
<h3>Importance</h3> Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits observationally associated with weight, but the causal nature these associations is uncertain. <h3>Objective</h3> To test for genetic evidence body mass index (BMI) related weight. <h3>Design, Setting, Participants</h3> Mendelian randomization whether BMI potentially causally offspring Data from 30 487 in 18 studies were analyzed....
Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role maternal genetic variation. We aimed to identify variants associated with that could highlight potentially relevant determinants growth. meta-analysed data up 8.7 million SNPs in 86 577 women European descent from Early Growth Genetics (EGG) Consortium and UK Biobank. used structural equation modelling (SEM) analyses mother-child pairs quantify separate effects....
Abstract Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in leptin ( LEP ) gene are well known to cause deficiency and severe obesity, no common loci regulating have been uncovered. Therefore, we performed a genome-wide association study (GWAS) from 32,161 individuals followed up reaching P <10 −6 19,979 additional individuals. We identify five robustly associated <5 × 10 −8 in/near , SLC32A1...