Massimo Mangino
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Telomeres, Telomerase, and Senescence
- Birth, Development, and Health
- Genetic and phenotypic traits in livestock
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Diabetes and associated disorders
- Genetic Syndromes and Imprinting
- Galectins and Cancer Biology
- Pancreatic function and diabetes
King's College London
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2015-2024
Imperial College London
2023-2024
St Thomas' Hospital
2013-2023
Thomas Foundation
2017-2022
St. Thomas Hospital
2022
National Institute for Health Research
2015-2021
Helsinki University Hospital
2020
University of Copenhagen
2020
Norwegian Institute of Public Health
2020
Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed joint analysis two genomewide association studies coronary artery disease.
A total of 2,618,862 participants reported their potential symptoms COVID-19 on a smartphone-based app. Among the 18,401 who had undergone SARS-CoV-2 test, proportion loss smell and taste was higher in those with positive test result (4,668 7,178 individuals; 65.03%) than negative (2,436 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval 6.31-7.21). model combining to predict probable infection applied data from all app users (805,753) predicted that 140,312 (17.42%)...
The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high 80×) nearly 10,000 individuals population-based disease collections. In extensively phenotyped cohorts characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel identify alleles associated with levels triglycerides (APOB), adiponectin (ADIPOQ) low-density...