A5059983518- Gut microbiota and health
- Bioinformatics and Genomic Networks
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Long-Term Effects of COVID-19
- melanin and skin pigmentation
- Skin Protection and Aging
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Nutrition, Health and Food Behavior
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Cutaneous Melanoma Detection and Management
- Machine Learning in Bioinformatics
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- COVID-19 and Mental Health
- T-cell and B-cell Immunology
- COVID-19 diagnosis using AI
- Biochemical Analysis and Sensing Techniques
- Galectins and Cancer Biology
- Bacteriophages and microbial interactions
King's College London
2016-2025
University of Turin
2009-2025
St Thomas' Hospital
2017-2025
Georgetown University
2025
Cancer Research And Biostatistics
2024
Human Technopole
2024
King's College - North Carolina
2022
Danone (France)
2020
University Medical Center Groningen
2020
Nutricia Research (Netherlands)
2020
A total of 2,618,862 participants reported their potential symptoms COVID-19 on a smartphone-based app. Among the 18,401 who had undergone SARS-CoV-2 test, proportion loss smell and taste was higher in those with positive test result (4,668 7,178 individuals; 65.03%) than negative (2,436 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval 6.31-7.21). model combining to predict probable infection applied data from all app users (805,753) predicted that 140,312 (17.42%)...
Abstract The human gut is inhabited by a complex and metabolically active microbial ecosystem. While many studies focused on the effect of individual taxa health, their overall metabolic potential has been under-explored. Using whole-metagenome shotgun sequencing data in 1,004 twins, we first observed that unrelated subjects share, average, almost double number pathways (82%) than species (43%). Then, using 673 blood 713 faecal metabolites, found to be associated with 34% 95% over 18,000...
Abstract The human microbiome is an integral component of the body and a co-determinant several health conditions 1,2 . However, extent to which interpersonal relations shape individual genetic makeup its transmission within across populations remains largely unknown 3,4 Here, capitalizing on more than 9,700 metagenomes computational strain-level profiling, we detected extensive bacterial strain sharing individuals (more 10 million instances) with distinct mother-to-infant, intra-household...
Abstract Importance A strategy for preventing further spread of the ongoing COVID-19 epidemic is to detect infections and isolate infected individuals without need extensive bio-specimen testing. Objectives Here we investigate prevalence loss smell taste among diagnosed identify combination symptoms, besides taste, most likely correspond a positive diagnosis in non-severe cases. Design Community survey. Setting Participants Subscribers RADAR COVID-19, an app that was launched use UK general...
As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus 2019 (COVID-19), we asked whether documenting time series over first few days informs outcome. Unsupervised clustering presentation was performed on data collected from a training dataset of completed cases enlisted early COVID Symptom Study Smartphone application, yielding six distinct presentations. Clustering validated an independent replication between 1 and 28 May 2020. Using 5...
Background The association between current tobacco smoking, the risk of developing symptomatic COVID-19 and severity illness is an important information gap. Methods UK users Zoe Symptom Study app provided baseline data including demographics, anthropometrics, smoking status medical conditions, were asked to log their condition daily. Participants who reported that they did not feel physically normal then by complete a series questions, 14 potential symptoms about hospital attendance. main...
The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changing environment are investigated for their role in the pathogenesis these complex diseases. Epigenome-wide association studies (EWASs) have revealed significant associations T2D, obesity, BMI with DNA methylation. However, populations from Middle East, where T2D rates highest worldwide,...
Abstract Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers ( n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of symptoms, including predicted COVID-19, a symptom-based algorithm predict true infection, derived from users tested for SARS-CoV-2. We found heritability 49% (32−64%) delirium; 34% (20−47%) diarrhea; 31% (8−52%) fatigue; 19% (0−38%) anosmia; 46% (31−60%) skipped meals and (11−48%)...
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report large genome-wide association study of ease tanning in 176,678 subjects European ancestry. We identify significant with ability at 20 loci. confirm previously identified associations six these loci, and 14 novel which ten have never been associated pigmentation-related phenotypes. Our results also suggest that variants the AHR/AGR3 locus, cutaneous malignant melanoma underlying mechanism...
Frailty, increased vulnerability to physiological stressors, is associated with adverse outcomes. COVID-19 exhibits a more severe disease course in older, comorbid adults. Awareness of atypical presentations critical facilitate early identification.
Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer-related therapy exacerbates the of COVID-19 infection is still limited. Data were collected COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants 1,784,293 without cancer, we documented 10,404 reports a positive test. Compared those living had 60% increased...
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide and a leading cause of renal failure. The mechanisms are not completely understood, but higher abundance galactose-deficient recognized to play crucial role in IgAN pathogenesis. Although both types human (IgA1 IgA2) have several N-glycans as post-translational modification, only IgA1 features extensive hinge-region O-glycosylation. galactose deficiency on O-glycans commonly detected by lectin-based method. To...
One of the challenging aspects SARS-CoV-2 infection is its diverse multisystemic disease presentation.To evaluate diagnostic value cutaneous manifestations and investigate their duration timing in relation to other COVID-19 symptoms.We used data from 336 847 UK users COVID Symptom Study app assess body rash or an acral infection, independent online survey 11 544 respondents skin-specific symptoms collect photographs.Using app, we show significant association between skin rashes a positive...
Yoghurt contains live bacteria that could contribute via modulation of the gut microbiota to its reported beneficial effects such as reduced body weight gain and lower incidence type 2 diabetes. To date, association between yoghurt consumption composition is underexplored. Here we used clinical variables, metabolomics, 16S rRNA shotgun metagenomic sequencing data collected on over 1000 predominantly female UK twins define link yoghurt-associated health benefits.
Abstract As no one symptom can predict disease severity or the need for dedicated medical support in COVID-19, we asked if documenting time series over first few days informs outcome. Unsupervised clustering presentation was performed on data collected from a training dataset of completed cases enlisted early COVID Symptom Study Smartphone application, yielding six distinct presentations. Clustering validated an independent replication between May 1-May 28 th , 2020. Using 5 logging, ROC-AUC...
Abstract Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true derived in users tested for SARS-CoV-2. We found heritability fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and gave 50 (29-70)%.
X-chromosome inactivation (XCI) silences one X in female cells to balance sex-differences X-dosage. A subset of X-linked genes escape XCI, but the extent which this phenomenon occurs and how it varies across tissues a population is as yet unclear. To characterize incidence variability individuals tissues, we conducted transcriptomic study adipose, skin, lymphoblastoid cell lines immune 248 healthy exhibiting skewed XCI. We quantify XCI from linear model genes' allelic fold-change XIST-based...
Viruses are an abundant and crucial component of the human microbiome, but accurately discovering them via metagenomics is still challenging. Currently, available viral reference genomes poorly represent diversity in microbiome samples, expanding such a set references difficult. As result, many viruses undetectable through even when considering power de novo metagenomic assembly binning, as lack universal markers. Here, we describe novel approach to catalog new members gut show how resulting...
isoUDCA are determined by the gut microbiome d levels associate with higher post-prandial lipemia and fasting appetite Higher correlate worse liver function enzyme values decrease post-bariatric surgery after fiber supplementation