Edward G. Lakatta
A5060742163- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Cardiovascular Health and Disease Prevention
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Ion Transport and Channel Regulation
- Cardiovascular Effects of Exercise
- Sodium Intake and Health
- Cerebrovascular and Carotid Artery Diseases
National Institute on Aging
2016-2025
National Institutes of Health
2016-2025
Institute on Aging
2016-2025
University of Cambridge
2024
National Institute on Drug Abuse
2011-2022
Government of the United States of America
2022
University of California, San Diego
2021
Type Media Center
2017
University of Pittsburgh
2001-2016
National Yang Ming Chiao Tung University
1998-2016
The obesity epidemic is responsible for a substantial economic burden in developed countries and major risk factor type 2 diabetes cardiovascular disease. disease the result not only of several environmental factors, but also genetic predisposition. To take advantage recent advances gene-mapping technology, we executed genome-wide association scan to identify variants associated with obesity-related quantitative traits genetically isolated population Sardinia. Initial analysis suggested that...
M uch has been published in the past 20 years on use of measurements arterial stiffness animal and human research studies.This summary statement was commissioned by American Heart Association to address issues concerning nomenclature, methodologies, utility, limitations, gaps knowledge this rapidly evolving field.The following represents an executive version larger online-only Data Supplement is intended give reader a sense why important, how it measured, situations which useful, its...
Background— Aging results in vascular stiffening and an increase the velocity of pressure wave as it travels down aorta. Increased aortic pulse (aPWV) has been associated with mortality clinical but not general populations. The objective this investigation was to determine whether aPWV is total cardiovascular (CV) CV events a community-dwelling sample older adults. Methods Results— measured at baseline 2488 participants from Health, Body Composition (Health ABC) study. Vital status, cause...
BACKGROUND It has been well established that arterial stiffness, manifest as an increase in pulse wave velocity or late systolic amplification of the carotid artery pressure pulse, increases with age. However, populations studied prior investigations were not rigorously screened to exclude clinical hypertension, occult coronary disease, diabetes. Furthermore, it is unknown whether exercise capacity chronic physical endurance training affects age-associated stiffness. METHODS AND RESULTS...
The ability of older persons to function independently is dependent largely on the maintenance sufficient aerobic capacity and strength perform daily activities. Although peak widely recognized decline with age, its rate has been estimated primarily from cross-sectional studies that may provide misleading, overly optimistic estimates aging changes.To determine longitudinal change in influence gender, physical activity these changes, we performed serial measurements treadmill oxygen...
Arterial stiffening with increased pulse pressure is a leading risk factor for cardiovascular disease in the elderly. We tested whether ALT-711, novel nonenzymatic breaker of advanced glycation end-product crosslinks, selectively improves arterial compliance and lowers older individuals vascular stiffening.Nine US centers recruited randomly assigned subjects resting pressures >60 mm Hg systolic >140 to once-daily ALT-711 (210 mg; n=62) or placebo (n=31) 56 days. Preexisting antihypertensive...
Normal Human Aging is an overview of the first 23 years research findings about natural course human aging. The Baltimore Longitudinal Study was started in 1958 to trace effects aging humans. BLSA recruited men aged 17 96 and women beginning 1978 participate repeated assessments health physical psychological performance. Visits were every two over 2 1/2 days.
To assess the effect of age on cardiac volumes and function in absence overt or occult coronary disease, we performed serial gated blood pool scans at rest during progressive upright bicycle exercise to exhaustion 61 participants Baltimore Longitudinal Study Aging. The subjects ranged from 25 79 years were free disease according their histories results physical, resting stress electrocardiographic, thallium scintigraphic examinations. Absolute left ventricular obtained each workload. There...
A progressive decline in maximal O2 consumption (VO2max) expressed traditionally as per kilogram body weight generally occurs with advancing age. To investigate the extent to which this could be attributable age-associated loss of metabolically active tissue, i.e., muscle, we measured 24-h urinary creatinine excretion, an index muscle mass, 184 healthy nonobese volunteers, ages 22-87 yr, from Baltimore Longitudinal Study Aging who had achieved a true VO2max during graded treadmill exercise....
Echocardiograms were performed on 105 male participants in the National Institutes Aging's volunteer Longitudinal Study Program. All subjects (25--84 years of age) physically active and had no evidence hypertension or cardiovascular disease. Measurements made initial diastolic (E-F) slope anterior mitral valve leaflet, aortic left ventricular cavity dimensions, thickness posterior wall. Fractional shortening minor semi-axis ventricle velocity circumferential fiber also determined. It was...