A5057361837- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Dialysis and Renal Disease Management
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Treatments and Studies
- Ethics in medical practice
- Economic and Financial Impacts of Cancer
- Peptidase Inhibition and Analysis
- Primary Care and Health Outcomes
- Patient Dignity and Privacy
- Cancer therapeutics and mechanisms
- Healthcare Policy and Management
- PARP inhibition in cancer therapy
- Neuroendocrine Tumor Research Advances
- Ethics and Legal Issues in Pediatric Healthcare
- Monoclonal and Polyclonal Antibodies Research
- Medical Malpractice and Liability Issues
- Cancer Immunotherapy and Biomarkers
Royal Surrey NHS Foundation Trust
2020-2025
Canterbury Christ Church University
2010-2025
Juravinski Cancer Centre
2016-2025
McMaster University
2015-2024
Hamilton Health Sciences
2005-2024
British Airways (United Kingdom)
2024
King's College London
2011-2023
Wellcome Sanger Institute
2013-2023
AstraZeneca (Canada)
2006-2023
Pfizer (Canada)
2023
How somatic mutations accumulate in normal cells is central to understanding cancer development but poorly understood. We performed ultradeep sequencing of 74 genes small (0.8 4.7 square millimeters) biopsies skin. Across 234 sun-exposed eyelid epidermis from four individuals, the burden averaged two six per megabase cell, similar that seen many cancers, and exhibited characteristic signatures exposure ultraviolet light. Remarkably, multiple are under strong positive selection even...
A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal validate the an independent group of patients.Patients (n = 307, 137 events after a median follow-up 13.6 years) from five European centers were divided into high- and low-risk groups based on gene classification clinical risk classifications. Patients assigned if their 5-year distant metastasis-free survival probability as estimated by greater than 90%. clinicopathologic...
Myelodysplastic syndromes are a diverse and common group of chronic hematologic cancers. The identification new genetic lesions could facilitate diagnostic therapeutic strategies.We used massively parallel sequencing technology to identify somatically acquired point mutations across all protein-coding exons in the genome 9 patients with low-grade myelodysplasia. Targeted resequencing gene encoding RNA splicing factor 3B, subunit 1 (SF3B1), was also performed cohort 2087 myeloid or other...
The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high 80×) nearly 10,000 individuals population-based disease collections. In extensively phenotyped cohorts characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel identify alleles associated with levels triglycerides (APOB), adiponectin (ADIPOQ) low-density...
Abstract Purpose: Recently, a 76-gene prognostic signature able to predict distant metastases in lymph node–negative (N−) breast cancer patients was reported. The aims of this study conducted by TRANSBIG were independently validate these results and compare the outcome with clinical risk assessment. Experimental Design: Gene expression profiling frozen samples from 198 N− systemically untreated done at Bordet Institute, blinded data independent Veridex. Genomic defined Veridex, data....
Purpose To provide evidence-based recommendations to update the American Society of Clinical Oncology guideline on systemic therapy for stage IV non–small-cell lung cancer (NSCLC). Methods An Update Committee NSCLC Expert Panel based a systematic review randomized controlled trials from January 2007 February 2014. Results This reflects changes in evidence since previous guideline. Recommendations There is no cure patients with NSCLC. For performance status (PS) 0 1 (and appropriate patient...
A number of microarray studies have reported distinct molecular profiles breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal ErbB2 subtypes are repeatedly recognized, identification estrogen receptor (ER) -positive has been inconsistent. Therefore, refinement their definition is needed.We previously a gene expression grade index (GGI), which defines histologic based on...
Multipotent neural stem cells are present throughout the development of central nervous system (CNS), persist into adulthood in defined locations and can be derived from more primitive embryonic cells. We show that SOX2, an HMG box transcription factor, is expressed multipotent at all stages mouse ontogeny. have generated transgenic mice expressing enhanced green fluorescent protein (EGFP) under control endogenous locus-regulatory regions <i>Sox2</i> gene to prospectively...
Purpose Etoposide and cisplatin (EP) has been a standard treatment for extensive-disease small-cell lung cancer (SCLC). An earlier phase III trial reported improved survival patients receiving irinotecan plus (IP) versus EP. Our was designed to determine if modified weekly regimen of IP would provide superior with less toxicity than Patients Methods The primary objective compare overall in SCLC randomly assigned receive (n = 221) or EP 110). were 2:1 ratio 30 mg/m 2 intravenously (IV) + 65...
CpG islands (CGIs) are dense clusters of sequences that punctuate the CpG-deficient human genome and associate with many gene promoters. As CGIs also differ from bulk chromosomal DNA by their frequent lack cytosine methylation, we devised a CGI enrichment method based on nonmethylated affinity chromatography. The resulting library was sequenced to define novel blood set includes not detected current algorithms. Approximately half were associated annotated transcription start sites, remainder...
Purpose Provide evidence-based recommendations updating the 2015 ASCO guideline on systemic therapy for patients with stage IV non-small-cell lung cancer (NSCLC). Methods The NSCLC Expert Panel made based a systematic review of randomized controlled trials from February 2014 to December 2016 plus Cancer Care Ontario Program in Evidence-Based Care's update previous search. Results This reflects changes evidence since update. Fourteen provide base; earlier phase also informed recommendation...
To identify preferences for the process of prognostic discussion among patients with incurable metastatic cancer and variables associated those preferences.One hundred twenty-six (58%) 218 invited onto study participated. Eligible were consecutive 30 oncologists, who diagnosed within 6 weeks to months before recruitment, over 18 years age, without known mental illness. Patients completed a postal survey measuring patient manner delivery information, including how doctors might instill...
Autism comprises a spectrum of behavioral and cognitive disturbances childhood development is known to be highly heritable. Although numerous approaches have been used identify genes implicated in the autism, less than 10% autism cases attributed single gene disorders. We describe use high-resolution genome-wide tilepath microarrays comparative genomic hybridization copy number variants within 119 probands from multiplex families. next carried out DNA methylation analysis by bisulfite...