Michael R. Stratton
A5058103562- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Evolution and Genetic Dynamics
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Renal and related cancers
- Genetics and Neurodevelopmental Disorders
- Chromosomal and Genetic Variations
- Testicular diseases and treatments
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Cancer-related Molecular Pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal cell carcinoma treatment
Wellcome Sanger Institute
2016-2025
Colon and Rectal Surgery Associates
2024
Institute of Cancer Research
2004-2023
Wellcome Trust
2002-2023
Boston Medical Center
2018
Maria Fertility Hospital
2017
Radboud University Nijmegen
2016
Dana-Farber Cancer Institute
2016
European Bioinformatics Institute
2005-2016
University of Oslo
2016
Alterations in cancer genomes strongly influence clinical responses to treatment and many instances are potent biomarkers for response drugs. The Genomics of Drug Sensitivity Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource information on drug sensitivity cells molecular markers response. Data freely available without restriction. GDSC currently contains data almost 75 000 experiments, describing 138 anticancer drugs across 700 cell lines. To identify response,...
SummaryThe contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage mutation analysis in 237 families, each with at least four cases cancer, collected the Breast Cancer Linkage Consortium. Families were included without regard occurrence ovarian or other cancers. Overall, disease linked an estimated 52% 32% neither gene 16% (95% confidence interval [CI] 6%–28%), suggesting predisposition genes. The majority (81%) breast-ovarian families due BRCA1, most others (14%)...
Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic signature 1 . Here, as part the Pan-Cancer Analysis Whole Genomes (PCAWG) Consortium 2 International Cancer Genome (ICGC) and The Atlas (TCGA), we characterized signatures using 84,729,690 somatic from 4,645 whole-genome 19,184 exome sequences that encompass most types cancer. We identified 49 single-base-substitution, 11 doublet-base-substitution, 4...
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which term chromothripsis, whereby tens hundreds of genomic rearrangements occur in one-off cellular crisis. Rearrangements involving one or few chromosomes crisscross back forth across involved regions, generating frequent oscillations between two copy number states. These hallmarks...
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is world's largest and most comprehensive resource for exploring impact of somatic mutations in human cancer. Our latest release (v70; Aug 2014) describes 2 002 811 coding point over one million tumor samples across genes. To emphasize depth knowledge on known cancer genes, mutation information curated manually from scientific literature, allowing very precise definitions disease types patient details....
COSMIC ( http://www.sanger.ac.uk/cosmic ) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding almost 542 tumour samples; of the 18 490 genes documented, 4803 (26%) have one or more mutations. Full scientific literature curations are available 83 major cancer and 49 fusion gene pairs (19 new 30 this year) number is continually increasing. Key amongst these TP53, now through a collaboration with IARC p53 database. In...
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance dominant susceptibility genes conferring high risk disease. genomic linkage search was performed with 15 high-risk cancer families that were unlinked BRCA1 locus on chromosome 17q21. This analysis localized second locus, BRCA2 , 6-centimorgan interval 13q12-13. Preliminary evidence suggests confers but, unlike does not confer substantially elevated ovarian cancer.
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature cancer. Using this information to guide development and application therapies in clinic is challenging. Here, we report how cancer-driven alterations identified 11,289 tumors from 29 tissues (integrating somatic mutations, copy number alterations, DNA methylation, gene expression) can be mapped onto 1,001 molecularly annotated human cell lines correlated with sensitivity 265 drugs. We find...
All cancers carry somatic mutations. A subset of these alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder passengers. Here we have sequenced genomes a malignant melanoma lymphoblastoid cell line from same person, providing first comprehensive catalogue mutations an individual cancer. The provides remarkable insights into forces that shaped this genome. dominant mutational signature reflects DNA damage due to...
How somatic mutations accumulate in normal cells is central to understanding cancer development but poorly understood. We performed ultradeep sequencing of 74 genes small (0.8 4.7 square millimeters) biopsies skin. Across 234 sun-exposed eyelid epidermis from four individuals, the burden averaged two six per megabase cell, similar that seen many cancers, and exhibited characteristic signatures exposure ultraviolet light. Remarkably, multiple are under strong positive selection even...