Anna González‐Neira
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Forensic and Genetic Research
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- Genetic diversity and population structure
- Gene expression and cancer classification
- Cancer Risks and Factors
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Ferroptosis and cancer prognosis
- DNA Repair Mechanisms
Spanish National Cancer Research Centre
2016-2025
Centre for Biomedical Network Research on Rare Diseases
2022-2025
Instituto de Salud Carlos III
2010-2025
Centro Nacional de Epidemiología
2005-2024
Texas A&M University
2024
Centro de Investigación del Cáncer
2013-2023
Cancer Research Center
2014-2021
Instituto Nacional do Câncer
2021
University of Manchester
2021
St Mary's Hospital
2021
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
Rare germline genetic variants in several genes are associated with increased breast cancer (BC) risk, but their precise contributions to different disease subtypes unclear. This information is relevant guidelines for gene panel testing and risk prediction.To characterize tumors BC susceptibility large-scale population- or hospital-based studies.The multicenter, international case-control analysis of the BRIDGES study included 42 680 patients 46 387 control participants, comprising women...
In order to identify genetic factors related thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved cell differentiation proliferation, found be differentially expressed carcinoma. A total of 768 97 were genotyped Spanish series 615 cases 525 controls, the former comprising largest collection patients with this pathology from single population date. an LD block spanning entire FOXE1 showed strongest evidence...
The presence of familial history in pheochromocytoma/paraganglioma patients, including syndromic antecedents, leads the majority cases to a positive genetic testing for mutations one major susceptibility genes described so far. Furthermore, it has been reported that absence about 11-24% patients also carry mutation these related genes. In cases, other clinical aspects like bilaterality, multiplicity, location tumors, or age at onset can help recognize underlying involved.The objective study...