A5016607688- Cancer Risks and Factors
- Cancer-related Molecular Pathways
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Venomous Animal Envenomation and Studies
- Cancer Mechanisms and Therapy
- Amphibian and Reptile Biology
- Digital Radiography and Breast Imaging
- Occupational and environmental lung diseases
- Protease and Inhibitor Mechanisms
- Error Correcting Code Techniques
- Gastric Cancer Management and Outcomes
- Ionic liquids properties and applications
- Opioid Use Disorder Treatment
- Cell Adhesion Molecules Research
- CO2 Reduction Techniques and Catalysts
- Global Cancer Incidence and Screening
- Neurogenesis and neuroplasticity mechanisms
- melanin and skin pigmentation
- Animal Behavior and Reproduction
- Anesthesia and Sedative Agents
- Pain Management and Opioid Use
- Genomics and Chromatin Dynamics
- AI in cancer detection
- Ovarian cancer diagnosis and treatment
Lifespan
2024
Rhode Island Hospital
2024
University of South Australia
2006-2023
Robert Bosch (Germany)
2023
Food and Nutrition Service
2020
Harvard University
2013-2017
Beth Israel Deaconess Medical Center
2013-2017
University of Illinois System
2016
Ambrx (United States)
2016
Fox Chase Cancer Center
2012
As part of an effort to examine the utility antibody–drug conjugates (ADCs) beyond oncology indications, a novel pyrophosphate ester linker was discovered enable targeted delivery glucocorticoids. small molecules, these highly soluble phosphate drug linkers were found have ideal orthogonal properties: robust plasma stability coupled with rapid release payload in lysosomal environment. Building upon findings, site-specific ADCs made between this combination and antibody against human CD70,...
Diagnosis and assessment of patients with prostate cancer is dependent on accurate interpretation grading histopathology. However, morphology does not necessarily reflect the complex biological changes occurring in disease progression, current biomarkers have demonstrated limited clinical utility patient assessment. This study aimed to develop that accurately define biology by distinguishing specific pathological features enable reliable pathology for Gleason patients. Online gene expression...
Article Female Pseudohermaphroditism Associated with a Novel Homozygous G-to-A (V370-to-M) Substitution in the P-450 Aromatase Gene was published on September 1, 1998 journal Journal of Pediatric Endocrinology and Metabolism (volume 11, issue 5).
Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates could be averted by early accurate detection. While detection currently reliant upon melanin visualisation, research into melanosome biogenesis, as a key driver pathogenesis, has not yielded technology that can reliably distinguish between atypical benign, amelanotic melanotic lesions. The endosomal-lysosomal system important regulatory roles in cancer cell biology, including specific functional role...
11027 Background: MicroRNAs (mirs) are non-coding RNAs of ≈22 nucleotides that suppress translation target genes by binding their mRNA and have a central role in gene regulation health disease. Malignant mesothelioma (MM) is an asbestos induced pleural neoplasm with median survival (MS) 12 months, relatively little known about the molecular events lead to development this highly aggressive Using unique platform, we examined whether there were distinct mir profiles between MM normal...
Opioid use is an epidemic that plagues the United States. Patients frequently present to emergency department (ED) after opioid toxicity, which can lead respiratory failure, apnea, and death. Although there effective antidote, naloxone, current guidelines surrounding post-naloxone administration monitoring are loosely defined. We a case in individual was administered naloxone intentional overdose monitored for four hours, as standard our institution. He remained ED additional workup...
Die Tumoren entstehen meist an der lateralen Nasenwand und sind mit Ausnahme weniger Fälle gutartig. Sie werden gefährlich, wenn sie in die knöchernen Strukturen des Gesichtsschädels, besonders harten Gaumens Orbita einbrechen. Therapie Wahl ist laterale Rhinotomie en-bloc-Resektion Siebbeins befallenen Seite. Prognose dann gut. Klassifikationen nach Schneider Skolnik bezeichnen nur Größe Tumoren. geben aber keinen Hinweis auf Prognose. deshalb überflüssig.
Abstract Background: Outdoor air pollution is considered a human carcinogen by the International Agency for Research on Cancer, particularly its influence lung cancer incidence and prognosis. While has not been consistently associated with breast incidence, only one study examined impacts of survival from was unable to consider important predictors mortality. We assessed whether PM exposures (PM2.5, PM2.510, PM10) were specific-death all-cause Methods: The Nurses’ Health Studies (NHS NHSII)...
Abstract Background Sex steroid hormone signaling is critical in the development and progression of breast cancers, though role androgens remains unspecified. Large epidemiologic studies have found a consistent association between circulating increased cancer risk, it unknown whether reflect androgenic milieu breast. An interaction androgen receptor (AR) estrogen (ER) has been postulated, wherein AR antagonizes ER estrogen-rich environments, induces proliferative effects estrogen-deplete...
Abstract Objective: Alcohol consumption is consistently positively associated with breast cancer risk in epidemiologic studies and the association generally appears stronger among estrogen receptor (ER) positive tumors. However, underlying biologic mechanism not completely understood. Methods: We evaluated pre-diagnostic alcohol intake relation to transcriptome profiles of invasive cancers diagnosed 1990-2009 Nurses’ Health Studies using a custom Affymetrix Human Transcriptome array. RNA was...
Abstract Background: This analysis aimed to determine if associations of prediagnostic mammographic percent breast density, absolute dense area, and non-dense area risk cancer vary according the subsequent tumors biomarker status. Methods: We included 1,154 postmenopausal women diagnosed with between June 1, 1989, 30, 2004, 2,078 matched controls from Nurses' Health Study I II. Percent areas were estimated digitized film mammograms using computer assisted thresholding techniques. Density...
…functionalization strategy has been developed for the large-scale preparation of aqueous processable high-quality semiconducting 2D triazine polymers.Intheir Research Article (e202301865), Yuxi Xu et al. demonstrate that obtained crystalline ultrathin polymer nanosheets can not only be assembled into ultralight and mechanically strong macroscopic porous aerogels,but also show a new surface molecule doping effect to significantly improve photocatalytic water splitting activity.Aqueous...
Abstract Background: High percent mammographic density (MD), which reflects the relative fibroglandular tissue content of breast, is one strongest breast cancer risk factors; however, pathologic mediators this are unknown. We hypothesize that analysis sections using deep learning approaches may characterize histologic features underpin associated with high MD. Methods: Non-targeted H&E stained diagnostic image-guided biopsies were evaluated among 588 women enrolled following an abnormal...
One method for approximating a-posteriori symbol probabilities is to marginalise over a reduced list of possible vectors. Several methods exist obtaining suitable lists (e.g. the sphere detector), but in many cases size required an accurate approximation may still be large. This paper describes implementation technique which removes requirement storage, with minimal increase complexity. The updates posterior place, and works any depth-first tree-search based detector. We then introduce novel...