A5049573827- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Testicular diseases and treatments
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Digital Radiography and Breast Imaging
- Cancer Risks and Factors
- Childhood Cancer Survivors' Quality of Life
- Sperm and Testicular Function
- Radiomics and Machine Learning in Medical Imaging
- Sexual Differentiation and Disorders
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Bladder and Urothelial Cancer Treatments
- BRCA gene mutations in cancer
- Colorectal Cancer Screening and Detection
- Renal and related cancers
- Hippo pathway signaling and YAP/TAZ
- Urological Disorders and Treatments
- Genetic Associations and Epidemiology
- Hormonal and reproductive studies
Karolinska Institutet
2015-2024
Svenska Örtmedicinska Institute
2017-2024
Ortoma (Sweden)
2024
Karolinska University Hospital
2004-2022
Harvard University
2011-2020
Brigham and Women's Hospital
2011-2015
Johns Hopkins University
2015
Trinity College Dublin
2013-2015
Harvard University Press
2014
Dana-Farber Cancer Institute
2012-2013
Undescended testis, which is a risk factor for testicular cancer, usually treated surgically, but whether the age at treatment has any effect on unclear. We studied relation between undescended testis and of cancer.We identified men who underwent orchiopexy in Sweden 1964 1999. Cohort subjects were Swedish Hospital Discharge Register followed occurrence cancer through Cancer Registry. Vital statistics data migration status taken from Population Changes years 1965 2000. estimated relative...
Background: PTEN is a tumor suppressor frequently deleted in prostate cancer that may be useful prognostic biomarker.However, the association of loss with lethal disease has not been tested large, predominantly surgically treated cohort. Methods:In Health Professionals Follow-up Study and Physicians' Study, we followed 1044 incident cases diagnosed between 1986 2009 for cancer-specific all-cause mortality.A genetically validated immunohistochemistry (IHC) assay was performed on tissue...
The mechanisms underlying the strong association between percentage dense area on a mammogram and risk of breast cancer are unknown. We investigated separately absolute nondense mammograms in relation to risk. conducted nested case-control study prediagnostic mammographic density measurements Nurses' Health Study II. Premenopausal were available from 464 cases 998 controls, postmenopausal 960 1,662 controls. used computer-assisted thresholding technique measure density, we unconditional...
TMPRSS2:ERG is a hormonally regulated gene fusion present in about half of prostate tumors. We investigated whether obesity, which deregulates several hormonal pathways, interacts with to impact cancer outcomes. The study included 1243 participants the prospective Physicians' Health Study and Professionals Follow-Up diagnosed between 1982 2005. ERG overexpression (a marker) was assessed by immunohistochemistry tumor tissue from radical prostatectomy or transurethral resection prostate. Body...
Abstract Background: Whether milk and dairy intake after a prostate cancer diagnosis is associated with poorer prognosis unknown. We investigated postdiagnostic in relation to risk of lethal (metastases death) among participants the Health Professionals Follow-Up Study. Methods: The cohort consisted 3,918 men diagnosed apparently localized between 1986 2006, followed 2008. Data on were available from repeated questionnaires. used Cox proportional hazards models calculate HRs 95% CIs...
Abstract Purpose: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis many cancers. The objective of this study was to characterize the association between cancer–specific survival. Experimental Design: included 879 participants U.S. Physicians' Health Study Professionals Follow-Up Study, diagnosed (1983–2004) treated by radical prostatectomy. Protein tumor expression evaluated immunohistochemistry on tissue microarrays. Results: Seventy-four (8%)...
Background: Prostate cancer has a propensity to invade and grow along nerves, phenomenon called perineural invasion (PNI). Recent studies suggest that the presence of PNI in prostate been associated with aggressiveness.Methods: We investigated association between lethal untreated treated cohorts: Swedish Watchful Waiting Cohort 615 men who underwent watchful waiting, U.S. Health Professionals Follow-Up Study 849 radical prostatectomy. One pathologist performed standardized histopathologic...
Objective: To describe study design and procedures for a prospective randomized trial investigating whether radical prostatectomy (RP) ± radiation improves cause-specific survival in comparison with primary treatment (RT) androgen deprivation (ADT) patients locally advanced prostate cancer (LAPC).Materials methods: SPCG-15 is prospective, multi-centre, open phase III trial. Patients are to either standard (RT + ADT) or experimental (RP extended pelvic lymph-node dissection addition of...
There are no conclusive results from randomized trials on radiotherapy (RT) versus radical prostatectomy (RP) for prostate cancer. Numerous observational studies have suggested that RP is associated with a lower risk of cancer death, but whether been biased due to limited adjustments confounding factors unknown.To compare the death after RT RP.Nationwide population-based study men in Prostate Cancer data Base Sweden 3.0 who had undergone or between 1998 and 2012.Prostate deaths were...
Circulating insulin-like growth factor-1 (IGF-1) is consistently associated with prostate cancer risk. IGF-1 binds to receptor (IGF1R) and insulin (IR), activating hallmark pathways. Experimental evidence suggests that TMPRSS2:ERG may interact IGF/insulin signaling influence progression. We investigated IGF1R IR expression its association lethal among 769 men. Protein of IGF1R, ERG (i.e. a surrogate fusion genes) were assayed by immunohistochemistry. Cox models estimated hazard ratios (HR)...
In many countries the incidence of testicular cancer has increased epidemically, but aetiology remains obscure. Maternal smoking during pregnancy been suggested to be a cause, satisfactorily valid assessment hypothesis is still lacking. To evaluate epidemiological relevance, we assessed ecological correlation between female habits and in Nordic countries. Data on prevalence among women 5-year birth cohorts 1910-1940, at 25-29 years age, were obtained through past studies Sweden, Denmark,...
Jakobsson T, Croner S, Kjellman N‐IM, Pettersson A, Vassella C, Björkstén B. Slight steroid‐sparing effect of intravenous immunoglobulin in children and adolescents with moderately severe bronchial asthma. Twenty subjects (aged 6‐20 years) asthma participated an open controlled trial (IVIG) given as five monthly infusions a mean dose 0.8 g/kg body weight. A follow‐up was performed 4 14 months after the treatment period. Nine group completed trial. Two experienced headache first infusion,...
In Sweden, human tissue samples obtained from diagnostic and surgical procedures have for decades been routinely stored in a formalin-fixed, paraffin-embedded, form. Through linkage with nationwide registers, these are available molecular studies to identify biomarkers predicting mortality even slow-progressing prostate cancer. However, fixation causes modifications of nucleic acids, making it challenging extract high-quality acids formalin fixated tissues. this study, the efficiency five...
Objectives To examine the risk of incident breast cancer in women with rheumatoid arthritis (RA), and RA a history cancer, taking antihormonal treatment for into account. Methods Using nationwide Swedish registers, new-onset diagnosed 2006–2016 were identified analysed using cohort case–control design. Each patient was matched on age, sex place residence to five randomly selected subjects from general population. Through register linkages, we collected information factors (reproductive...
Abstract Background: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation AR exists, including a polymorphic CAG repeat sequence that inversely associated with transcriptional activity. Experimental data suggest heightened activity facilitates formation of TMPRSS2:ERG, fusion present approximately 50% tumors patients cancer. Methods: We undertook nested case–control study to investigate the hypothesis shorter length would be risk...
Background In the United States, half of men with prostate cancer harbor androgen-regulated gene fusion TMPRSS2:ERG. We hypothesized that TMPRSS2:ERG positive tumors are more responsive to androgen deprivation therapy (ADT). Methods studied a cohort 239 from Physicians' Health Study and Professionals Follow-up who received ADT during their disease course. Fusion status was assessed on available tumor tissue by immunohistochemistry for ERG protein expression. used Cox models calculate hazard...