A5004918315- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Digital Radiography and Breast Imaging
- Breast Cancer Treatment Studies
- AI in cancer detection
- Colorectal Cancer Screening and Detection
- Breast Lesions and Carcinomas
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- MRI in cancer diagnosis
- COVID-19 and healthcare impacts
- Artificial Intelligence in Healthcare
- Cancer Genomics and Diagnostics
- Infrared Thermography in Medicine
- Breast Implant and Reconstruction
- Advanced Fluorescence Microscopy Techniques
- Lung Cancer Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Smoking Behavior and Cessation
- Gene expression and cancer classification
- Medical Imaging Techniques and Applications
- Palliative Care and End-of-Life Issues
University of Vermont
2016-2025
Kaiser Permanente Washington Health Research Institute
2012-2025
University of California, Davis
2013-2025
Dartmouth College
2013-2025
University of Washington
2014-2025
Fred Hutch Cancer Center
2014-2025
Dartmouth Institute for Health Policy and Clinical Practice
2014-2025
Huntsman Cancer Institute
2025
University of Illinois Chicago
2025
Florida College
2023
Purpose To establish performance benchmarks for modern screening digital mammography and assess trends over time in U.S. community practice. Materials Methods This HIPAA-compliant, institutional review board–approved study measured the of interpreted by 359 radiologists across 95 facilities six Breast Cancer Surveillance Consortium (BCSC) registries. The included 1 682 504 mammograms performed between 2007 2013 792 808 women. Performance measures were calculated according to American College...
National legislation is under consideration that would require women with mammographically dense breasts to be informed of their breast density and encouraged discuss supplemental cancer screening health care providers. The number US potentially affected by this unknown. We determined the mammographic distribution age body mass index (BMI) using data from 1518 599 mammograms conducted 2007 through 2010 at mammography facilities in Breast Cancer Surveillance Consortium (BCSC). applied these...
<h3>Importance</h3> Given recent advances in screening mammography and adjuvant therapy (treatment), quantifying their separate combined effects on US breast cancer mortality reductions by molecular subtype could guide future decisions to reduce disease burden. <h3>Objective</h3> To evaluate the contributions associated with treatment based estrogen-receptor (ER) human epidermal growth factor receptor 2 (<i>ERBB2</i>, formerly<i>HER2</i>or<i>HER2/neu</i>). <h3>Design, Setting,...
Background: Controversy persists about optimal mammography screening strategies. Objective: To evaluate outcomes, taking into account advances in and treatment of breast cancer. Design: Collaboration 6 simulation models using national data on incidence, digital performance, effects, other-cause mortality. Setting: United States. Patients: Average-risk U.S. female population subgroups with varying risk, density, or comorbidity. Intervention: Eight strategies differing by age at which starts...
Twenty-one states have laws requiring that women be notified if they dense breasts and advised to discuss supplemental imaging with their provider.To better direct discussions of by determining which combinations breast cancer risk Breast Imaging Reporting Data System (BI-RADS) density categories are associated high interval rates.Prospective cohort.Breast Cancer Surveillance Consortium (BCSC) facilities.365,426 aged 40 74 years who had 831,455 digital screening mammography...
Many states have laws requiring mammography facilities to tell women with dense breasts and negative results on screening discuss supplemental tests their providers. The most readily available method is ultrasonography, but little known about its effectiveness.To evaluate the benefits, harms, cost-effectiveness of ultrasonography for breasts.Comparative modeling 3 validated simulation models.Surveillance, Epidemiology, End Results Program; Breast Cancer Surveillance Consortium; medical...
Many established breast cancer risk factors are used in clinical prediction models, although the proportion of cancers explained by these is unknown.To determine population-attributable (PARP) for associated with among premenopausal and postmenopausal women.Case-control study 1:10 matching on age, year factor assessment, Breast Cancer Surveillance Consortium (BCSC) registry. Risk data were collected prospectively from January 1, 1996, through October 31, 2012, BCSC community-based imaging...
Breast cancer screening examinations using digital breast tomosynthesis (DBT) has been shown to be associated with decreased false-positive test results and increased detection compared mammography (DM). Little is known regarding the size stage of types detected their association age density.To determine whether DBT detect cancers that are an improved prognosis compare rates by patient density.This retrospective analysis prospective cohort data from 3 research centers in Population-based...
About half of the United States has legislation requiring radiology facilities to disclose mammographic breast density information women, often with language recommending discussion supplemental screening options for women dense breasts.To examine variation in assessment across radiologists clinical practice.Cross-sectional and longitudinal analyses prospectively collected observational data.30 within 3 cancer research centers Population-based Research Optimizing Screening through...
The coronavirus disease 2019 (COVID-19) pandemic has disrupted breast cancer control through short-term declines in screening and delays diagnosis treatments. We projected the impact of COVID-19 on future mortality between 2020 2030.Three established Cancer Intervention Surveillance Modeling Network models modeled reductions mammography use, symptomatic diagnosis, reduced use chemotherapy for women with early-stage first 6 months return to prepandemic patterns after that time. Sensitivity...
The effects of breast cancer incidence changes and advances in screening treatment on outcomes different strategies are not well known.
Short-term declines in postmenopausal hormone use were observed after the Women's Health Initiative trial results 2002. Although concerns about trial's generalizability have been expressed, long-term trends a nationally representative sample not reported. We sought to evaluate national prevalence of and assess variation by type formulation patient characteristics.We examined during 1999-2010 using cross-sectional data from 10,107 women aged 40 years older National Nutrition Examination...
Women who live in geographic areas with high poverty rates and low levels of education experience poorer survival after a breast cancer diagnosis than women communities indicators socioeconomic status (SES). However, very few studies have examined individual-level SES relation to or assessed the contextual role community-level independent SES.The authors this report both population-based cohort ages 20 69 years were diagnosed Wisconsin between 1995 2003 (N = 5820).Compared college graduates,...
Molecular characterization of breast cancer allows subtype-directed interventions. Estrogen receptor (ER) is the longest-established molecular marker.We used six established population models with ER-specific input parameters on age-specific incidence, disease natural history, mammography characteristics, and treatment effects to quantify impact screening adjuvant therapy age-adjusted US mortality by ER status from 1975 2000. Outcomes included stage-shifts absolute relative reductions in...
Purpose/Objectives: To evaluate the process of survivorship care plan (SCP) completion and to survey oncology staff primary physicians (PCPs) regarding challenges implementing SCPs.
Collagen fibers surrounding breast ducts may influence cancer progression. Syndecan-1 interacts with constituents in the extracellular matrix, including collagen fibers, and contribute to cell migration. Thus, orientation of ductal carcinoma
Purpose To evaluate the effectiveness of combined biennial digital mammography and tomosynthesis screening, compared with screening alone, among women dense breasts. Materials Methods An established, discrete-event breast cancer simulation model was used to estimate comparative clinical cost-effectiveness both versus alone U.S. aged 50–74 years breasts from a federal payer perspective lifetime horizon. Input values were estimated for test performance, costs, health state utilities National...
Digital mammography (DM) and digital breast tomosynthesis (DBT) are used for routine cancer screening. There is minimal evidence on performance outcomes by age, screening round, density in community practice.To compare DM vs DBT baseline subsequent category.This comparative effectiveness study assessed 1 584 079 examinations of women aged 40 to 79 years without prior history cancer, mastectomy, or augmentation undergoing at 46 participating Breast Cancer Surveillance Consortium facilities...
Purpose To establish contemporary performance benchmarks for diagnostic digital mammography with use of recent data from the Breast Cancer Surveillance Consortium (BCSC). Materials and Methods Institutional review board approval was obtained active or passive consenting processes to obtain a waiver consent enroll participants, link data, perform analyses. Data were six BCSC registries (418 radiologists, 92 radiology facilities). Mammogram indication assessments prospectively collected women...