A5077710776- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- Economic and Financial Impacts of Cancer
- MRI in cancer diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Radiology practices and education
- Menopause: Health Impacts and Treatments
- Medical Imaging Techniques and Applications
- Cancer survivorship and care
- Bone health and osteoporosis research
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Artificial Intelligence in Healthcare
- Healthcare cost, quality, practices
- Advances in Oncology and Radiotherapy
- Cancer Genomics and Diagnostics
Kaiser Permanente Washington Health Research Institute
2015-2024
Kaiser Permanente
2000-2024
Grail (United States)
2023-2024
Menlo School
2023-2024
University of Washington
2012-2023
University of California, San Francisco
2003-2023
Illumina (United States)
2023
Seattle University
2006-2022
Dartmouth College
2009-2021
University of Vermont
2003-2021
After the US Food and Drug Administration (FDA) approved computer-aided detection (CAD) for mammography in 1998, Centers Medicare Medicaid Services (CMS) provided increased payment 2002, CAD technology disseminated rapidly. Despite sparse evidence that improves accuracy of mammographic interpretations costs over $400 million a year, is currently used most screening mammograms United States.To measure performance digital with without community practice.We compared interpreted (n = 495 818) vs...
Purpose To establish performance benchmarks for modern screening digital mammography and assess trends over time in U.S. community practice. Materials Methods This HIPAA-compliant, institutional review board–approved study measured the of interpreted by 359 radiologists across 95 facilities six Breast Cancer Surveillance Consortium (BCSC) registries. The included 1 682 504 mammograms performed between 2007 2013 792 808 women. Performance measures were calculated according to American College...
Risk prediction models for breast cancer can be improved by the addition of recently identified risk factors, including density and use hormone therapy. We used prospective information to predict a diagnosis in cohort 1 million women undergoing screening mammography.There were 2,392,998 eligible mammograms from without previously diagnosed who had prior mammogram preceding 5 years. Within year mammogram, 11,638 with cancer. Separate logistic regression constructed premenopausal...
<h3>Importance</h3> Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography accuracy by reducing missed cancers and false positives. <h3>Objective</h3> To evaluate whether AI can overcome interpretation limitations with a rigorous, unbiased evaluation of machine learning algorithms. <h3>Design, Setting, Participants</h3> In this diagnostic study conducted between September 2016 November 2017, an...
Purpose: To retrospectively evaluate the range of performance outcomes radiologist in an audit screening mammography by using a representative sample U.S. radiologists to allow development benchmarks for mammography. Materials and Methods: Institutional review board approval was obtained, study HIPAA compliant. Informed consent or not obtained according institutional guidelines. Data from 188 mammographic facilities 807 between 1996 2002 were analyzed six registries Breast Cancer...
Five years of adjuvant tamoxifen therapy for estrogen receptor (ER) -positive breast cancer is more effective than 2 use. However, information on discontinuation scanty. We sought to identify predictors among older women with cancer.Within six health care delivery systems, we identified >or= 65 old diagnosed stage I IIB ER-positive or indeterminant between 1990 and 1994 who had filled a prescription tamoxifen. observed them 5 after initial prescription. used automated pharmacy records...
Accurate long-term breast cancer risk assessment for women attending routine screening could help reduce the disease burden and intervention-associated harms by personalizing recommendations preventive interventions.
Background Although several clinical breast cancer risk models are used to guide screening and prevention, they have only moderate discrimination. Purpose To compare selected existing mammography artificial intelligence (AI) algorithms the Breast Cancer Surveillance Consortium (BCSC) model for prediction of 5-year risk. Materials Methods This retrospective case-cohort study included data in women with a negative mammographic examination (no visible evidence cancer) 2016, who were followed...
Background: Younger women (40–49 years) have lower mammographic sensitivity (i.e., greater proportion of cancers detected after a negative mammogram) than older (≥50 years). We explored the effect tumor growth rate, breast density, image quality, and cancer risk factors on in younger women. Methods: studied 576 (n = 73 aged 40–49 years n 503 50 or older) who were diagnosed with invasive between 1988 1993. Interval defined as those within 12 24 months screening mammogram before subsequent...
BackgroundWhether a change over time in clinically measured mammographic breast density influences cancer risk is unknown.
To identify radiologists' characteristics associated with interpretive performance in screening mammography.The study was approved by institutional review boards of University Washington (Seattle, Wash) and institutions at seven Breast Cancer Surveillance Consortium sites, informed consent obtained, procedures were HIPAA compliant. Radiologists who interpreted mammograms U.S. regions completed a self-administered mailed survey; information on demographics, practice type, experience...
Purpose We determined whether the association between breast density and cancer risk severity differs according to menopausal status postmenopausal hormone therapy (HT) use. Methods collected data on 587,369 women who underwent 1,349,027 screening mammography examinations; 14,090 were diagnosed with cancer. calculated 5-year from a survival model for subgroups of classified by their Breast Imaging Reporting Data System (BIRADS) density, age, status, current HT use, assuming body mass index...
In Brief OBJECTIVE: We sought to examine prescribing patterns (prevalence and rates of initiation discontinuation) for estrogen plus progestin (hormone therapy [HT] alone [ET]) in the United States 2 years before published results Women's Health Initiative's (WHI) HT trial's early termination 5 months after their release. METHODS: conducted an observational cohort study 169,586 women aged 40–80 who were enrolled health maintenance organizations estimate prevalence ET discontinuation between...
Chinese translation Background: The effectiveness of screening colonoscopy in average-risk adults is uncertain, particularly for right colon cancer. Objective: To examine the association between and risk incident late-stage colorectal cancer (CRC). Design: Nested case–control study. Setting: Four U.S. health plans. Patients: 1039 enrolled at least 5 years one Case patients were aged 55 to 85 on their diagnosis date (reference date) stage IIB or higher (late-stage) CRC during 2006 2008. One 2...
A substantial literature describes age-dependent variations in breast cancer treatment, showing that older women are less likely to receive standard treatment than younger women. We sought identify patient and tumor characteristics associated with the nonreceipt of primary systemic adjuvant therapies.We studied 1,859 age 65 years or stage I II diagnosed between 1990 1994 who were cared for six geographically dispersed community-based health care systems. collected demographic, tumor,...
The increasing availability of electronic health records (EHRs) creates opportunities for automated extraction information from clinical text. We hypothesized that natural language processing (NLP) could substantially reduce the burden manual abstraction in studies examining outcomes, like cancer recurrence, are documented unstructured text, such as progress notes, radiology reports, and pathology reports. developed an NLP-based system using open-source software to process notes 1995 2012...
Compared with film, digital mammography has superior sensitivity but lower specificity for women aged 40 to 49 years and dense breasts. Digital replaced film in virtually all US facilities, overall population health cost from use of this technology are unclear. Using five independent models, we compared screening strategies starting at age or 50 applied annually, biennially, based on density biennial ages 74 no screening. Common data elements included cancer incidence test performance, both...
Moving to multigene testing for all women with breast cancer (BC) could identify many more mutation carriers who can benefit from precision prevention. However, the cost-effectiveness of this approach remains unaddressed.To estimate incremental lifetime effects, costs, and patients BC compared current practice genetic (BRCA) based on family history (FH) or clinical criteria.This microsimulation modeling study costs effects high-risk BRCA1/BRCA2/PALB2 (multigene) unselected (strategy A)...
Breast magnetic resonance imaging (MRI) is highly sensitive for detecting breast cancer. Low specificity, cost, and little evidence regarding mortality benefits, however, limit recommendations its use to high-risk women. How MRI actually used in community settings unknown.To describe trends indications a setting.Retrospective cohort study at not-for-profit health plan multispecialty group medical practice New England of 10,518 women aged 20 years older enrolled the least 1 year who had...