Larry G. Kessler

ORCID: 0000-0002-8024-5424
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About
Contact & Profiles
Research Areas
  • Global Cancer Incidence and Screening
  • Health Systems, Economic Evaluations, Quality of Life
  • Healthcare Policy and Management
  • Colorectal Cancer Screening and Detection
  • Mental Health Treatment and Access
  • Radiomics and Machine Learning in Medical Imaging
  • Musculoskeletal pain and rehabilitation
  • Economic and Financial Impacts of Cancer
  • Lung Cancer Treatments and Mutations
  • BRCA gene mutations in cancer
  • Lung Cancer Diagnosis and Treatment
  • Spine and Intervertebral Disc Pathology
  • Appendicitis Diagnosis and Management
  • Breast Cancer Treatment Studies
  • Dialysis and Renal Disease Management
  • Intraperitoneal and Appendiceal Malignancies
  • Cancer Genomics and Diagnostics
  • Cancer Risks and Factors
  • Cervical Cancer and HPV Research
  • Meta-analysis and systematic reviews
  • Cystic Fibrosis Research Advances
  • Global Health Care Issues
  • Healthcare cost, quality, practices
  • Statistical Methods in Clinical Trials
  • Cardiac, Anesthesia and Surgical Outcomes

University of Washington
2016-2025

Washington State Department of Health
2025

University of Arizona
2025

Institute of Translational Health Sciences
2024

Seattle University
2010-2023

Washington Center
2022-2023

Providence Regional Medical Center Everett
2021

Olive View-UCLA Medical Center
2021

Harbor–UCLA Medical Center
2021

Swedish Medical Center
2021

• Utilization of health and mental services by noninstitutionalized persons aged 18 years older is examined based on interviews with probability samples 3,000 to 3,500 In each three sites the National Institute Mental Health Epidemiologic Catchment Area (ECA) program: New Haven, Conn, Baltimore, St Louis. all ECAs, 6% 7% adults made a visit during prior six months for reasons; proportions were considerably higher among recent DSM-III disorders covered Diagnostic Interview Schedule (DIS) or...

10.1001/archpsyc.1984.01790210053007 article EN Archives of General Psychiatry 1984-10-01

The National Cancer Institute and the Health Care Financing Administration share a strong research interest in cancer costs, access to prevention treatment services, patient outcomes. To develop database for such research, two agencies have undertaken collaborative effort link Medicare Program data with Surveillance, Epidemiology, End Results (SEER) database. SEER is system of 9 population-based tumor registries that collect standardized clinical information on cases diagnosed separate,...

10.1097/00005650-199308000-00006 article EN Medical Care 1993-08-01

The decline in death rates from cervical cancer the United States has been widely attributed to use of Papanicolaou (Pap) smears for early detection cancer.Pap smear screening rates, beliefs about appropriate intervals and factors affecting were examined using 1987 National Health Interview Survey data.Results indicate that through age 69, Blacks are screened at similar or higher than Whites. Hispanics, particularly those speaking only mostly Spanish, least likely have received a Pap within...

10.2105/ajph.81.7.885 article EN American Journal of Public Health 1991-07-01

Background : Clinical trials have demonstrated that use of mammographic screening and advances in therapy can improve prognosis for women with breast cancer. Purpose We determined the trends cancer mortality rates, as well incidence survival rates by extent disease at diagnosis, white United States considered whether these are consistent widespread such beneficial medical interventions. Methods examined data from National Center Health Statistics Surveillance, Epidemiology, End Results...

10.1093/jnci/88.21.1571 article EN JNCI Journal of the National Cancer Institute 1996-11-06

This paper is an analysis of data on symptoms depression in a nationwide sample adults, collected during the National Center for Health Statistics' first and Nutrition Examination Survey. The are analyzed by statistical adjustment procedure which assesses impact major sociodemographic variables simultaneously, instead one one, avoids former source confusion. measure Epidemiologic Studies Depression (CES-D) Scale. With exception race, study replicates earlier findings. facilitates...

10.1093/oxfordjournals.aje.a113218 article EN American Journal of Epidemiology 1981-10-01

October 1997Breast Cancer Surveillance Consortium: a national mammography screening and outcomes database.Authors: R Ballard-Barbash, S H Taplin, B C Yankaskas, V L Ernster, D Rosenberg, P A Carney, W E Barlow, … Show All , M Geller, K Kerlikowske, Edwards, F Lynch, N Urban, Chrvala, Key, Poplack, J Worden, G Kessler FewerAuthor Info & AffiliationsVolume 169, Issue 4https://doi.org/10.2214/ajr.169.4.9308451 METRICS PDF

10.2214/ajr.169.4.9308451 article EN American Journal of Roentgenology 1997-10-01

In addition to demographic and health care-related characteristics, the age physiologic status of women at time breast cancer diagnosis have been reported influence receipt standard treatments. Previous studies comorbidity not examined whether other patient-, region-, or characteristics altered association with type treatment received.This study factors associated breast-conserving surgery radiation therapy, both which are recommended treatments for cancer, among a cohort 18,704 aged 65...

10.1093/jnci/88.11.716 article EN JNCI Journal of the National Cancer Institute 1996-06-05

Although investigators in the imaging community have been active developing and evaluating quantitative biomarkers (QIBs), development implementation of QIBs hampered by inconsistent or incorrect use terminology methods for technical performance statistical concepts. Technical is an assessment how a test performs reference objects subjects under controlled conditions. In this article, some relevant concepts are reviewed, that can be used comparing described, issues related to discussed. More...

10.1148/radiol.2015142202 article EN Radiology 2015-08-12

Epidural glucocorticoid injections are widely used to treat symptoms of lumbar spinal stenosis, a common cause pain and disability in older adults. However, rigorous data lacking regarding the effectiveness safety these injections.In double-blind, multisite trial, we randomly assigned 400 patients who had central stenosis moderate-to-severe leg receive epidural glucocorticoids plus lidocaine or alone. The received one two before primary outcome evaluation, performed 6 weeks after...

10.1056/nejmoa1313265 article EN New England Journal of Medicine 2014-07-02

The development and implementation of quantitative imaging biomarkers has been hampered by the inconsistent often incorrect use terminology related to these markers. Sponsored Radiological Society North America, an interdisciplinary group radiologists, statisticians, physicists, other researchers worked develop a comprehensive serve as foundation for biomarker claims. Where possible, this working adapted existing definitions derived from national or international standards bodies rather than...

10.1177/0962280214537333 article EN Statistical Methods in Medical Research 2014-06-11

Although extensive resources go to cancer care, national population-based data on the costs of such care at patient level have been unavailable. Medicare payments subsequent diagnosis for elderly enrollees with five common cancers were estimated using tumor registry from Surveillance, Epidemiology, and End Results Program linked claims 1984 1990. The time between death was divided into four phases corresponding clinical course solid tumors, average each phase (including services not related...

10.1097/00005650-199508000-00007 article EN Medical Care 1995-08-01

OBJECTIVES: Mammography rates reported by women in the National Health Interview Surveys of 1990 and 1987 are examined. Why this screening modality is not more frequently used explored. METHODS. Data from Surveys, conducted Center for Statistics, cross-tabulated compared. RESULTS. In 1987, approximately 17% over 40 years age having had a mammogram previous year. 1990, rate doubled. Race declined importance; income education remained strong, positive predictors screening. CONCLUSIONS. Despite...

10.2105/ajph.84.1.62 article EN American Journal of Public Health 1994-01-01

• Despite extensive documentation of high rates psychiatric morbidity among primary care patients, there have been, to our knowledge, no US studies following up these patients over time. We analyzed data based on two administrations the Schedule for Affective Disorders and Schizophrenia-Lifetime version (SADS-L) six months apart 166 attenders at a clinic in Marshfield, Wis. In short span between interviews, 35% study group exhibited least one Research Diagnostic Criteria disorder, almost...

10.1001/archpsyc.1985.01790290065007 article EN Archives of General Psychiatry 1985-06-01

• Several methods are used to minimize and measure error in the NIMH Epidemiologic Catchment Area program. Sampling involve inclusion of group quarters such as prisons, nursing homes, mental hospitals sample frame use probability sampling throughout. Interviewing, include identical diagnostic interview protocols, centralized training supervisors, standard instructions interviewers, reinterview a subsample by clinicians. In area completion, 75% 80% respondent completion rate, 95% or greater...

10.1001/archpsyc.1984.01790210024004 article EN Archives of General Psychiatry 1984-10-01

Cancer incidence and mortality do not fully reflect the effect of cancer. To estimate number persons alive who have a history cancer, we derived prevalence rates based on data from Connecticut Tumor Registry. We did attempt to distinguish between people had been cured cancer those still disease. In 1982 age-adjusted among males females were 1,789 2,222, respectively, per 100,000. Age-specific highest elderly; 12 percent men 11 women over 70 previously given diagnosis Breast in prostate two...

10.1056/nejm198611273152206 article EN New England Journal of Medicine 1986-11-27

In Brief OBJECTIVE: We sought to examine prescribing patterns (prevalence and rates of initiation discontinuation) for estrogen plus progestin (hormone therapy [HT] alone [ET]) in the United States 2 years before published results Women's Health Initiative's (WHI) HT trial's early termination 5 months after their release. METHODS: conducted an observational cohort study 169,586 women aged 40–80 who were enrolled health maintenance organizations estimate prevalence ET discontinuation between...

10.1097/01.aog.0000143826.38439.af article EN Obstetrics and Gynecology 2004-11-01

Screening mammography in community practice: positive predictive value of abnormal findings and yield follow-up diagnostic procedures.M L Brown, F Houn, E A Sickles G KesslerAudio Available | Share

10.2214/ajr.165.6.7484568 article EN American Journal of Roentgenology 1995-12-01

Data from the Epidemiologic Catchment Area study were used to compare demographic characteristics and psychiatric symptomatology of persons classified into four groups based on source mental health services: clergy only, specialists both specialists, neither source. Those receiving services more likely have major affective panic disorders than those who sought or only neither. in care substance abuse disorders. as seeing serious The data make clear need for formal linkages between professionals.

10.1176/ps.39.10.1064 article EN Psychiatric Services 1988-10-01

Based on data from the five sites of National Institute Mental Health-sponsored Epidemiologic Catchment Area (ECA) Program, this paper examines prevalence psychiatric disorder among recent medical service users versus nonusers, with a particular focus affective disorders, substance abuse/dependence, and phobias. The rate current Diagnostic Interview Schedule (DIS) disorders in all ECA is 21.7 per cent (slightly higher than general population rates) 16.7 nonusers; there generally no...

10.2105/ajph.77.1.18 article EN American Journal of Public Health 1987-01-01

Stationary hemodialysis machines hinder mobility and limit activities of daily life during dialysis treatments. New technologies are needed to improve patient autonomy enhance quality life.We conducted a FDA-approved human trial wearable artificial kidney, miniaturized, machine, based on dialysate-regenerating sorbent technology. We aimed determine the efficacy kidney in achieving solute, electrolyte, volume homeostasis up 10 subjects over 24 hours.During study, all remained hemodynamically...

10.1172/jci.insight.86397 article EN JCI Insight 2016-06-01

In contrast to the recommendations for younger adults, many guidelines allow older adults with back pain undergo imaging without waiting 4 6 weeks. However, early may precipitate interventions that do not improve outcomes.To compare function and at 12-month follow-up visit among who received those did receive after a new primary care radiculopathy.Prospective cohort of 5239 patients 65 years or (2011-2013) in 3 US health systems. We matched controls 1:1 using propensity score matching...

10.1001/jama.2015.1871 article EN JAMA 2015-03-17
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