A5039863504- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Spine and Intervertebral Disc Pathology
- Complementary and Alternative Medicine Studies
- Cerebrovascular and Carotid Artery Diseases
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Cardiovascular Health and Disease Prevention
- HIV/AIDS Research and Interventions
- Acupuncture Treatment Research Studies
- Acute Ischemic Stroke Management
- HIV, Drug Use, Sexual Risk
- Global Cancer Incidence and Screening
- Meta-analysis and systematic reviews
- Clinical practice guidelines implementation
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Anesthesia and Pain Management
- Pharmacology and Obesity Treatment
- Migraine and Headache Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Prostate Cancer Treatment and Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
Kaiser Permanente
2016-2025
University of California, San Francisco
2014-2024
Colorado Permanente Medical Group
2024
University of Washington
2017-2023
Kaiser Permanente Oakland Medical Center
2017-2022
Community Link
2021
Kaiser Permanente San Francisco Medical Center
2021
VA Puget Sound Health Care System
2021
Kaiser Permanente Sacramento Medical Center
2019
Kaiser Permanente Center for Health Research
2018
To revise the 2003 version of American Urological Association's (AUA) Guideline on management benign prostatic hyperplasia (BPH).From MEDLINE® searches English language publications (January 1999 through February 2008) using relevant MeSH terms, articles concerning index patient, a male ≥45 years age who is consulting healthcare provider for lower urinary tract symptoms (LUTS) were identified. Qualitative analysis evidence was performed. Selected studies stratified by design, comparator,...
Background: Acupuncture is a popular complementary and alternative treatment for chronic back pain.Recent European trials suggest similar short-term benefits from real sham acupuncture needling.This trial addresses the importance of needle placement skin penetration in eliciting effects patients with low pain.Methods: A total 638 adults mechanical pain were randomized to individualized acupuncture, standardized simulated or usual care.Ten treatments provided over 7 weeks by experienced...
Saw palmetto is used by over 2 million men in the United States for treatment of benign prostatic hyperplasia and commonly recommended as an alternative to drugs approved Food Drug Administration.In this double-blind trial, we randomly assigned 225 age 49 years who had moderate-to-severe symptoms one year with saw extract (160 mg twice a day) or placebo. The primary outcome measures were changes scores on American Urological Association Symptom Index (AUASI) maximal urinary flow rate....
Epidural glucocorticoid injections are widely used to treat symptoms of lumbar spinal stenosis, a common cause pain and disability in older adults. However, rigorous data lacking regarding the effectiveness safety these injections.In double-blind, multisite trial, we randomly assigned 400 patients who had central stenosis moderate-to-severe leg receive epidural glucocorticoids plus lidocaine or alone. The received one two before primary outcome evaluation, performed 6 weeks after...
Optimal management of patients with asymptomatic severe carotid stenosis is uncertain, due to advances in medical care and a lack contemporary data comparing surgical treatment.To estimate stroke outcomes among medically treated who did not undergo intervention.Retrospective cohort study that included 3737 adult participants (70%-99%) diagnosed between 2008 2012 no prior intervention or ipsilateral neurologic event the 6 months. Participants received follow-up through 2019, all were members...
Background: There is no standard method of identifying adverse events in clinical trials. Objective: To determine whether 3 different methods questioning patients about a trial affect the frequency reported events. Design: Randomized, single-blind, controlled trial. Setting: A Veterans Administration medical center, San Francisco, California. Participants: Men 50 years age or older who had benign prostatic hyperplasia. Measurement: Frequency self-reported problems. Intervention: The authors...
Saw palmetto fruit extracts are widely used for treating lower urinary tract symptoms attributed to benign prostatic hyperplasia (BPH); however, recent clinical trials have questioned their efficacy, at least standard doses (320 mg/d).To determine the effect of saw extract (Serenoa repens, from berries) up 3 times dose on BPH.A double-blind, multicenter, placebo-controlled randomized trial 11 North American sites conducted between June 5, 2008, and October 10, 2010, 369 men aged 45 years or...
Purpose: To assess feasibility and preliminary efficacy of a mobile/online-based (mHealth) mindfulness intervention for cancer patients their caregivers to reduce distress improve quality life (QoL). Material Methods: Two-arm randomized controlled trial within Kaiser Permanente Northern California targeting who received chemotherapy informal caregivers. The group commercially available program 8 weeks. wait-list control usual care. We assessed using retention adherence rates obtained...
In contrast to the recommendations for younger adults, many guidelines allow older adults with back pain undergo imaging without waiting 4 6 weeks. However, early may precipitate interventions that do not improve outcomes.To compare function and at 12-month follow-up visit among who received those did receive after a new primary care radiculopathy.Prospective cohort of 5239 patients 65 years or (2011-2013) in 3 US health systems. We matched controls 1:1 using propensity score matching...
IMPORTANCEOral steroids are commonly used to treat acute sciatica due a herniated disk but have not been evaluated in an appropriately powered clinical trial.OBJECTIVE To determine if oral prednisone is more effective than placebo improving function and pain among patients with sciatica.DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, placebo-controlled trial conducted from 2008 2013 large integrated health care delivery system Northern California.Adults (n=269) radicular for 3...
This analysis of the lumbar epidural steroid injections for spinal stenosis multicenter randomized controlled trial data identifies degree and risk factors cortisol suppression after in older adults with stenosis. Four hundred patients aged 50 years back or leg pain central completed baseline demographic psychosocial measures. Morning serum levels were measured at 3 weeks initial injection. Patients to receive either local anesthetic corticosteroid (n = 200) only 200). The specific was...
<b>Objective </b>To examine the attitudes of US patients about use placebo treatments in medical care. <b>Design</b> One time telephone surveys. <b>Setting</b> Northern California. <b>Participants </b>853 members Kaiser Permanente California, aged 18-75, who had been seen by a primary care provider for chronic health problem at least once prior six months. <b>Results </b>The response rate was 53.4% (853/1598) all were eligible to participate, and 73.2% (853/1165) could be reached telephone....
Preplanned secondary analysis of data from participants receiving acupuncture in a randomized clinical trial.To determine whether patients' expectations and preferences for predict short long-term treatment outcomes persons with chronic back pain.Although accumulating evidence suggests that patient may outcomes, few studies have examined this relationship acupuncture.Four hundred seventy-seven acupuncture-naïve low pain who were to 1 3 or simulated treatments the focus analysis. Ten provided...
Abstract Inguinal hernia repair is one of the most commonly performed operations in world, yet little known about genetic mechanisms that predispose individuals to develop inguinal hernias. We perform a genome-wide association analysis surgically confirmed hernias 72,805 subjects (5,295 cases and 67,510 controls) confirm top associations an independent cohort 92,444 with self-reported surgeries (9,701 82,743 controls). identify four novel susceptibility loci regions EFEMP1 , WT1 EBF2 ADAMTS6...
Faster treatment with intravenous alteplase in acute ischemic stroke is associated better outcomes. Starting 2015, Kaiser Permanente Northern California redesigned its workflow across all 21 centers to (1) follow a single standardized version of modified Helsinki model and (2) have emergency cases managed by dedicated telestroke neurologist. We examined the effect California's Stroke EXpediting PRrocess Evaluating Stopping program on door-to-needle (DTN) time, use, symptomatic intracranial...
Prospective cohort study.To determine whether there are distinct trajectories of back pain and function among older adults to identify characteristics that distinguish patients with substantially different prognoses.Although the differential diagnosis course low may differ from middle-aged adults, is little evidence. Better understanding variability in recovery help target for more intensive clinical interventions, plan resource use, design studies homogeneous patient groups.Patients aged 65...
Migraine is a common disabling primary headache disorder that ranked as the most neurological cause of disability worldwide. Women present with migraine much more frequently than men, but reasons for this difference are unknown. heritability estimated to up 57%, yet genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate etiology disorder, we conduct multiethnic genome-wide association meta-analysis migraine, combining results from GERA and UK...