A5010801722- Opioid Use Disorder Treatment
- Cancer Risks and Factors
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Pain Management and Opioid Use
- Estrogen and related hormone effects
- Pharmaceutical Practices and Patient Outcomes
- Prenatal Substance Exposure Effects
- Statistical Methods in Clinical Trials
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Cancer, Stress, Anesthesia, and Immune Response
- Blood Pressure and Hypertension Studies
- Substance Abuse Treatment and Outcomes
- Global Cancer Incidence and Screening
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacogenetics and Drug Metabolism
- Advanced Causal Inference Techniques
- Medication Adherence and Compliance
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare Policy and Management
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Acute Ischemic Stroke Management
Kaiser Permanente Washington Health Research Institute
2016-2025
Genetech (Sri Lanka)
2024
HealthPartners
2022
MultiCare Health System
2022
Henry Ford Health System
2022
Kaiser Permanente
2013-2022
University of Washington
2012-2021
Seattle University
2007-2021
University of Rhode Island
2021
University of Calgary
2017-2019
This paper describes characteristics of opioid use episodes for noncancer pain and defines thresholds de facto long-term therapy.CONSORT (CONsortium to Study Opioid Risks Trends) includes adult members 2 health plans serving over 1% the US population. beginning in years 1997 2005 were classified as acute, episodic, long-term/lower dose, or long-term/higher dose.On basis evaluation likelihood continuing, therapy was defined by lasting longer than 90 days with 10+ prescriptions 120+ supply...
Abstract Objective To report trends and characteristics of long‐term opioid use for non‐cancer pain. Methods CONSORT (CONsortium to Study Opioid Risks Trends) includes adult enrollees two health plans serving over 1 per cent the US population. Using automated data, we constructed episodes between 1997 2005. We estimated age–sex standardized rates beginning in each year (incident) on‐going (prevalent), change annualized (PCA) 9‐year period. Long‐term were defined as > 90 days with 120+...
Objectives. We describe age and gender trends in long-term use of prescribed opioids for chronic noncancer pain 2 large health plans. Methods. Age- gender-standardized incident (beginning each year) prevalent (ongoing) opioid episodes were estimated with automated care data from 1997 to 2005. Profiles 2005 by also compared. Results. From 2005, age–gender groups exhibited a total percentage increase ranging 16% 87% 61% 135% use. Women had higher than did men. Older women the highest...
ABSTRACT Purpose The objective of this study was to describe trends in the prevalence regular aspirin and nonsteroidal anti‐inflammatory drug (NSAID) use among adults United States during 2005 2010, identify characteristics users. Methods Data from 2010 National Health Interview Survey (NHIS) were analyzed estimate NSAIDs U.S. aged 18 years older. Results stratified by demographics self‐reported medical conditions extrapolated provide population estimates. In around 43 million (19.0%) took...
More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate blood pressure, raising concerns about their cardiovascular safety.To examine whether current prescribed primarily to treat ADHD is associated with increased risk serious events in young middle-aged adults.Retrospective, population-based cohort study using electronic health care records from 4 sites (OptumInsight...
We describe the design, implementation, and use of a large, multiorganizational distributed database developed to support Mini-Sentinel Pilot Program US Food Drug Administration (FDA). As envisioned by FDA, this implementation will inform facilitate development an active surveillance system for monitoring safety medical products (drugs, biologics, devices) in USA.A common data model was designed address priorities leverage experience participating organizations partners. A review existing...
IMPORTANCEObesity is associated with chronic noncancer pain.It not known if opioid use for pain in obese individuals undergoing bariatric surgery reduced.OBJECTIVES To determine following patients using opioids chronically control prior to their and the effect of preoperative depression, pain, or postoperative changes body mass index (BMI) on use.DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study a distributed health network (10 demographically geographically varied US care...
Background: This study compared prevalent health utilization and costs for persons with without metabolic syndrome investigated the independent associations of various factors that make up syndrome. Methods: Subjects were enrollees three plans who had all clinical measurements (blood pressure, fasting plasma glucose, body mass index, triglycerides, high-density lipoprotein cholesterol) necessary to determine risk over 2-year period (n = 170,648). We used values, International Classification...
Abstract Purpose To determine the prevalence of persistent pulmonary hypertension newborn (PPHN) among infants whose mothers were exposed to antidepressants in third trimester pregnancy compared not trimester. Methods A retrospective study was conducted using automated databases four health plans participating HMO Research Network Center for Education and on Therapeutics. Women who delivered an infant a hospital from 1 January 1996 through 31 December 2000 identified. The administrative used...
Long-term opioid therapy for non-cancer pain has increased. Caution is advised in prescribing persons with substance use disorders, but little known about actual health plan practices. This paper reports trends and characteristics of long-term a abuse history. Using data (1997–2005), the study compared age–sex-standardized rates incident, incident prevalent prescription use, medication profiles those without disorder histories. The CONsortium to Study Opioid Risks Trends included adult...
Few individual adverse effects or patient characteristics were significantly associated with endocrine therapy discontinuation, yet prevalent and the most commonly reported reason for discontinuation.
Abstract BACKGROUND Limited data are available regarding the incidence of breast carcinoma among users relatively recently introduced forms antihypertensive therapy. Although it has been suggested that women who have taken calcium channel blockers (CCBs) an increased risk and angiotensin‐I‐converting enzyme (ACE) inhibitors a decreased risk, currently, no conclusions can be drawn. METHODS A population‐based case–control study ages 65–79 years was conducted in western Washington State. The...
Purpose. The impact of pharmacist interventions on the care and outcomes patients with depression in a primary setting was evaluated. Methods. Patients diagnosed new episode started anti-depressant medications were randomized to enhanced (EC) or usual (UC) for one year. EC consisted collaborating providers facilitate patient education, initiation adjustment antidepressant dosages, monitoring adherence regimen, management adverse reactions, prevention relapse. UC group served as controls....
Abstract Purpose Active surveillance of population‐based health networks may improve the timeliness detection adverse drug events (ADEs). monitoring requires sequential analysis methods. Our objectives were to (1) evaluate utility automated healthcare claims data for near real‐time event and (2) identify key methodological issues related use safety surveillance. Methods We assessed ability detect ADEs using historical from nine plans involved in HMO Research Network's Center Education on...
A validation study evaluated the accuracy of self-reported use commonly used medications among older women. Within a case-control breast cancer, drug information was ascertained by interview. Pharmacy records from 1990 to 1999 were obtained Washington State health maintenance organization (66% subjects) and retail pharmacies (34% on sample subjects (212 cases, 191 controls) as "gold standard." Recall assessed for 6-month, 2-year, 8-year time windows. Sensitivity antihypertensive 92% (95%...
ABSTRACT Purpose In post‐marketing drug safety surveillance, data mining can potentially detect rare but serious adverse events. Assessing an entire collection of drug–event pairs is traditionally performed on a predefined level granularity. It unknown priori whether causes very specific or set related events, such as mitral valve disorders, all different types heart disease. This methodological paper evaluates the tree‐based scan statistic method to enhance surveillance. Methods We use...
Purpose Little is known about opioid use after bariatric surgery among patients who did not opioids chronically before surgery. Our purpose was to determine the year pre-surgery and identify characteristics associated with chronic Methods This retrospective cohort study across nine US health systems included 10 643 aged 21 years or older underwent were users pre-surgery. The main outcome post-surgery (excluding 30 post-operative days) defined as ≥10 dispensings over ≥90 days ≥120 total days'...