Suleeporn Sangrajrang
A5055685453- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Genetic Associations and Epidemiology
- Cervical Cancer and HPV Research
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- HER2/EGFR in Cancer Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition, Genetics, and Disease
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Hepatitis B Virus Studies
- Genomic variations and chromosomal abnormalities
- Economic and Financial Impacts of Cancer
- Cancer Risks and Factors
- Carcinogens and Genotoxicity Assessment
- CRISPR and Genetic Engineering
Ministry of Public Health
2015-2025
National Cancer Institute of Thailand
2014-2024
University of Kentucky
2022
Markey Cancer Center
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Amsterdam University Medical Centers
2022
American Cancer Society
2022
National Cancer Center
2022
Phramongkutklao College of Medicine
2018
Health Promotion Board
2018
Abstract The aim of this study was to identify a biomarker that could improve alpha-fetoprotein (AFP) performance in hepatocellular carcinoma (HCC) surveillance among patients with cirrhosis. We performed proteomic profiling plasma from cirrhosis or HCC and validated selected candidate biomarkers two geographically distinct cohorts include different etiologies. Mass spectrometry highly fractionated 18 17 identified osteopontin (OPN) as significantly up-regulated cases, compared controls. OPN...
Significance In cancer, the metabolism of copper and sulfur are dysregulated, leading to deleterious side effects. These issues commonly addressed by studying variations concentrations elements, but here we have used, for first time our knowledge, stable isotope compositions variations, using methods widespread in Earth sciences. We show that hepatocellular carcinomas patients, blood enriched light isotopes compared with control subjects. isotopic signatures not compatible a dietary origin,...
<h3>Background</h3> BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family DNA repair proteins. Biallelic mutations in <i>BRIP1</i> are responsible for FANC J, and previous studies have also suggested that rare truncating variants associated with an increased risk breast cancer. These led to inclusion on targeted sequencing panels cancer prediction. <h3>Methods</h3> We evaluated a variant, p.Arg798Ter (rs137852986), 10...
It is quite well documented that the COVID-19 pandemic disrupted cancer screening services in all countries, irrespective of their resources and healthcare settings. While quantitative estimates on reduction volume tests or diagnostic evaluation are readily available from high-income very little data low- middle-income countries (LMICs). From CanScreen5 global repository we identified six LMICs through purposive sampling based availability at least for years 2019 2020. These represented...
Genome-wide association studies have identified FGFR2 as a breast cancer (BC) susceptibility gene in populations of European and Asian descent, but causative variant has not yet been conclusively identified. We hypothesized that the weaker linkage disequilibrium across this associated region African ancestry might help refine set candidate-causal single nucleotide polymorphisms (SNPs) previously by our group. Eight SNPs were evaluated 1253 American invasive BC cases 1245 controls. A...
Estrogen and its metabolites are believed to play important roles in breast cancer, determinants include both genetic lifestyle factors. The objective of the study is investigate association cancer risk Thailand with polymorphisms several genes involved estrogen synthesis metabolism. Five hundred seventy patients histopathologically confirmed 497 controls were included present study. Forty single nucleotide (SNPs) CYP1A1, CYP1A2, CYP1B1, CYP17, CYP19, CYP2C9, CYP2C19, AhR, ESR1, PGR, ERRG,...
In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily European-ancestry populations. SNPs 31 showed an with risk at P < 0.05 direction consistent that reported previously. Twenty-one them remained statistically significant after adjusting for multiple comparisons the...
Breast cancer risks conferred by many germline missense variants in the
Objective Colorectal cancer (CRC) is the third-most and fifth-most common in men women, Thailand. The increasing CRC incidence mortality can be reduced by screening treating adenomas early cancers. A pilot programme using immunochemical faecal occult blood testing (iFOBT) colonoscopy for test-positives were implemented through routine Government Health Services Lampang Province, to inform acceptability, feasibility scaling-up of This report describes implementation, coverage performance...
Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants risk prediction models has not evaluated adequately women Asian ancestry.
Abstract Thailand is among countries with the highest global incidence and mortality rates of hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (iCCA). While viral hepatitis liver fluke infections have been associated HCC iCCA, respectively, other environmental risk factors, overall factor commonality combinatorial roles, effects on survival not systematically examined. We conducted a TIGER‐LC consortium‐based population study covering all high‐incidence areas both malignancies...
ABSTRACT Colorectal cancer incidence rates vary geographically and have changed over time. Notably, in the past two decades, of early-onset colorectal cancer, affecting individuals under age 50 years, has doubled many countries. The reasons for this increase are unknown. Here, we investigate whether mutational processes contribute to geographic age-related differences by examining 981 genomes from 11 No major were found microsatellite unstable cancers, but variations mutation burden...
To evaluate the relationship between obesity, diet, physical activity and breast cancer in Thai women, we conducted a case control study with 1,130 cases 1,142 controls. Informed consent was obtained from all participants structured questionnaire performed by trained interviewers to collect information on demographic anthropometric data, reproductive medical history, residential occupation as well dietary habits. A significant positive association an increased risk of observed women body...
Background Adverse biological effects from airborne pollutants are a primary environmental concern in highly industrialized areas. Recent studies linked air pollution exposures with altered blood Deoxyribo-nucleic acid (DNA) methylation, but industrial sources and underlying mechanisms still largely unexplored. Methods The Ma Ta Phut estate (MIE) Rayong, Thailand hosts one of the largest steel, oil refinery petrochemical complexes south-eastern Asia. We measured panel DNA methylation markers...
Chronic Hepatitis B (HB) is the main risk factor for chronic liver disease (CLD) and hepatocellular carcinoma (HCC) in many low-resource countries, where diagnosis constrained by lack of clinical, histopathological biomarker resources. We have used proteomics to detect plasma biomarkers that outperform α-Fetoprotein (AFP), most widely HCC contexts. Deep-plasma proteome analysis was performed patients, patients with CLD HB-carrier controls from Thailand (South-East Asia) The Gambia...