A5090614363- Carcinogens and Genotoxicity Assessment
- Occupational and environmental lung diseases
- Air Quality and Health Impacts
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Indoor Air Quality and Microbial Exposure
- Genetic factors in colorectal cancer
- Pesticide Exposure and Toxicity
- Pesticide and Herbicide Environmental Studies
- DNA Repair Mechanisms
- Occupational exposure and asthma
- Head and Neck Surgical Oncology
- Epigenetics and DNA Methylation
- Weed Control and Herbicide Applications
- Sinusitis and nasal conditions
- Glutathione Transferases and Polymorphisms
- Chronic Lymphocytic Leukemia Research
- Toxic Organic Pollutants Impact
- Global Cancer Incidence and Screening
- Sleep and Work-Related Fatigue
- Water Treatment and Disinfection
- Head and Neck Cancer Studies
- Anesthesia and Pain Management
- Genetic Associations and Epidemiology
- School Health and Nursing Education
Expro (United Kingdom)
2023
Istituto per lo Studio e la Prevenzione Oncologica
2016-2022
Division of Cancer Epidemiology and Genetics
2021
National Cancer Institute
2021
University of Cagliari
2020
Piedmont Reference Center for Epidemiology and Cancer Prevention
2009-2019
Institut Català d'Oncologia
2012
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2012
Andalusian School of Public Health
2012
Instituto de Salud Pública de Navarra
2012
Formaldehyde is an ubiquitous pollutant to which humans are exposed. Pathologists can experience high formaldehyde exposure levels. Formaldehyde—among other properties—induce oxidative stress and free radicals, react with DNA lipids, leading damage lipid peroxidation, respectively. We measured the levels of air-formaldehyde in a group Italian pathologists controls. analyzed effect on leukocyte malondialdehyde−deoxyguanosine adducts (M1-dG), biomarker peroxidation. studied relationship...
Background Adverse biological effects from airborne pollutants are a primary environmental concern in highly industrialized areas. Recent studies linked air pollution exposures with altered blood Deoxyribo-nucleic acid (DNA) methylation, but industrial sources and underlying mechanisms still largely unexplored. Methods The Ma Ta Phut estate (MIE) Rayong, Thailand hosts one of the largest steel, oil refinery petrochemical complexes south-eastern Asia. We measured panel DNA methylation markers...
Although rare, sinonasal cancers (SNCs) have a high occupational attributable fraction. We applied gender-based approaches to descriptive analyses, incidence, and patterns of exposures using the Italian National Sinonasal Cancer Registry (ReNaTuNS: Registro Nazionale Tumori Naso-Sinusali). The study included 2851 SNC patients. was diagnosed more often in men (73%) than women (27%). most frequent morphology intestinal-type adenocarcinoma (33%), whereas women, it squamous cell carcinoma (49%)....
This study has analysed the generation of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine adduct [M1dG], a biomarker oxidative stress and lipid peroxidation, in breast fine-needle aspirate samples 22 patients with cancer, at different clinical stages, respect to 13 controls. The multivariate analysis show that M1dG was higher cases than controls (Mean Ratio (MR) = 5.26, 95% CI 3.16–8.77). Increased observed women tumour grade 3 pathological diameter 2 (MR...
The (32)P-post-labelling assay has emerged as a major tool for detecting bulky DNA adducts in subjects exposed to carcinogens, especially aromatic compounds. However, the protocol still requires use of high amounts radioactivity, i.e. 25-50 muCi per sample, an obstacle that limits its large studies. characterization measured is also limited. Methodological improvements and increased adduct are necessary make this capable achieving higher throughput. A new was tested ensure efficient...
Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location largest steel, oil refinery, and petrochemical factory complexes Southeast Asia. Air pollution an important source oxidative stress reactive oxygen species, which interact with DNA lipids, leading damage lipid peroxidation, respectively.We measured malondialdehyde-deoxyguanosine (dG) adducts, a biomarker workers, nearby residents,...
Abstract Introduction We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to clinical characteristics the in older children (10 years or older), adolescents and young adults (up age 24). Methods Information records was obtained for 899 BT cases, including signs symptoms, symptom onset, diagnosis date, tumor type location. Results Overall, 64% all were low-grade, 76% neuroepithelial 62% gliomas. There more males than females among...
Evidence for the human health effects of pesticides is needed to inform risk assessment. We studied relationship between occupational insecticide use and non-Hodgkin lymphoma (NHL) by pooling data from nine case-control studies participating in InterLymph Consortium, including 7909 cases 8644 controls North America, European Union Australia. Insecticide was coded using self-report or expert assessment, groups (eg, organophosphates, pyrethroids) active ingredients malathion, permethrin)....
Aromatic compounds such as polycyclic aromatic hydrocarbons, arylamines and heterocyclic amines require metabolic activation to form metabolites able bind DNA, a process mediated by polymorphic enzymes. We measured DNA adducts in white blood cells the 32 P-post-labelling assay sample of 296 healthy adults (147 men 149 women) from five regions Spain. also analyzed functional polymorphisms genes CYP1A1 , CYP1A2 EPHX1 GSTM1 GSTT1 NAT2 SULT1A1 . A significant increased level was found related...
Abstract Background: Colorectal (CRC) and gastric cancer (GC) are associated with meat intake tobacco smoke, maybe because of aromatic compounds occurring in smoking formed during cooking meat. Activated metabolites these may bind to DNA forming bulky adducts. Methods: Forty-eight subjects diagnosed GC 154 CRC a 7-year follow-up period the European Prospective Investigation into Cancer Nutrition–Spain cohort were compared sample 296 using case–cohort approach. Aromatic adducts from...
Abstract Background The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into association between occupational exposure to glyphosate and risk of lymphoma subtypes in multicenter case-control study conducted Italy. Methods Italian Gene-Environment Interactions Lymphoma Etiology (ItGxE) took place 2011–17 six centres. Overall, 867 incident cases 774 controls participated study....
Objectives Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk non-Hodgkin’s lymphoma (NHL) in a large, pooled study. Methods We data from 10 case-control studies participating International Lymphoma Epidemiology Consortium, including 9229 cases 9626 controls North America, European Union Australia. Herbicide was coded self-report or by expert assessment individual studies, groups (eg, phenoxy herbicides)...
Parental occupational exposures around conception (father) or during pregnancy (mother) have been hypothesized as potential predisposing factors for childhood leukaemia. We investigated parental exposure to several known carcinogens and leukaemia risk. conducted a pooled analysis using case-control data from four European countries (3362 leukemia cases 6268 controls). polycyclic aromatic hydrocarbons (PAH), diesel engine exhaust (DEE), chromium, nickel, crystalline silica, asbestos were...
Brain tumours (BTs) are one of the most frequent tumour types in young people. We explored association between tap water, exposure to trihalomethanes (THM) and nitrate neuroepithelial BT risk Analysis water consumption were based on 321 cases 919 appendicitis controls (10-24 years old) from 6 14 participating countries international MOBI-Kids case-control study (2010-2016). Available historical residential concentrations THMs nitrate, available 3 for 86 352 85 343 respectively, modelled...
Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed polymorphisms in two repair genes, for example, XRCC1 Arg194Trp Arg399Gln genes XRCC3 Thr241Met gene, 34 cancer cases respect 30 subjects with benign disease 40 healthy controls. When the study population was categorized base number of risk alleles, were significantly increased individuals bearing 3‐4 alleles (OR = 4.1 95% C.I. 1.28–13.09, P .009). A significant association smoking...
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the clonal expansion of malignant B cells. To predict clinical course disease, identification diagnostic biomarkers urgently needed. Aberrant methylation patterns may CLL development and its course, being very early changes during carcinogenesis. Our aim was to identify specific evaluate whether aberrations in selected genes are associated with gene expression. Here, performing genome-wide analysis, we...
Introduction. Formaldehyde, a colorless and highly irritating substance, causes cancer of the nasopharynx leukemia. Furthermore, it is one environmental mutagens to which humans are most abundantly exposed. Acetaldehyde was recently classified as carcinogen class 1B mutagen 2 in Annex VI EC regulation. Occupational exposure two aldehydes occurs wide variety occupations industries. The aim this study deepen non-traditional productive sectors bakeries pastry producers. Methods. evaluation...
Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet in 120 controls 67 Map Ta Phut industrial estate workers Rayong, Thailand, evaluate influence fruit vegetables, fried charcoal-grilled/barbecued food consumption on M(1)dG. was decreased reporting consume 14-17 servings/week vegetables (mean ratio [MR]= 0.35, CI 0.18-0.69, p< 0.05). Conversely, non-statistically significant increment detected...
The Map-Ta-Phut Industrial Estate (MIE) in Rayong, Thailand, is the location of one largest industrial complexes southeastern Asia. MIE complex produces a mixture air pollutants, including polycyclic aromatic hydrocarbons, compounds capable to induce generation DNA adducts. adducts are considered be biomarker carcinogen exposure; however, its production can modulated by genetic susceptibility. Thus, we analysed influence EPHX1 His139Arg (A>G, rs2234922) and NQO1 Pro187Ser (C>T, rs1800566)...
The aim of this study is to highlight tasks and jobs not commonly considered at high risk for sinonasal cancer (SNC) identified by Regional Operating Centers currently active in the Italian National Sinonasal Cancer Registry (ReNaTuNS), which retrieve occupational histories through a standardized questionnaire. Data on exposures IARC carcinogenic agents work settings unknown be associated with SNC were collected analyzed. Out 2,208 cases recorded ReNaTuNS database, 216 their worked exposure...