A5043574267- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- DNA and Nucleic Acid Chemistry
- Microfluidic and Capillary Electrophoresis Applications
- Carcinogens and Genotoxicity Assessment
- Chemical Synthesis and Analysis
- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Protein purification and stability
- Metabolomics and Mass Spectrometry Studies
- Fluorine in Organic Chemistry
- Analytical chemistry methods development
- Innovative Microfluidic and Catalytic Techniques Innovation
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Electrochemical Analysis and Applications
- Molecular Biology Techniques and Applications
- Analytical Chemistry and Sensors
- Effects and risks of endocrine disrupting chemicals
- Organoselenium and organotellurium chemistry
- Molecular Sensors and Ion Detection
- Inorganic and Organometallic Chemistry
- Synthesis and Biological Evaluation
- Selenium in Biological Systems
- Various Chemistry Research Topics
Northeastern University
2015-2024
Universidad del Noreste
2014-2017
University of Bahrain
2013-2015
Institute for Scientific Interchange
2010
University of Turin
2010
Brigham and Women's Hospital
2009
Harvard University
2009
Center for Environmental Health
1998
Massachusetts Institute of Technology
1998
Quincy College
1997
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh performance liquid chromatography of proteins on a diol-bonded silica gel stationary phaseDonald E. Schmidt, Roger W. Giese, Dana. Conron, and Barry L. KargerCite this: Anal. Chem. 1980, 52, 1, 177–182Publication Date (Print):January 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ac50051a040https://doi.org/10.1021/ac50051a040research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions involving electron transfer. I. Reduction of 2,2,6,6-tetramethyl-4-hepten-3-oneKerry W. Bowers, Roger Giese, James Grimshaw, Herbert O. House, Nancy H. Kolodny, Karlheinz Kronberger, and David K. RoeCite this: J. Am. Chem. Soc. 1970, 92, 9, 2783–2799Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1...
Formaldehyde is an ubiquitous pollutant to which humans are exposed. Pathologists can experience high formaldehyde exposure levels. Formaldehyde—among other properties—induce oxidative stress and free radicals, react with DNA lipids, leading damage lipid peroxidation, respectively. We measured the levels of air-formaldehyde in a group Italian pathologists controls. analyzed effect on leukocyte malondialdehyde−deoxyguanosine adducts (M1-dG), biomarker peroxidation. studied relationship...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions involving electron transfer. II. Reductions of enones with alkali metal solutionsHerbert O. House, Roger W. Giese, Karlheinz Kronberger, Jean P. Kaplan, and Joseph F. SimeoneCite this: J. Am. Chem. Soc. 1970, 92, 9, 2800–2810Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 1970https://pubs.acs.org/doi/10.1021/ja00712a033https://doi.org/10.1021/ja00712a033research-articleACS...
This study performed a comprehensive assessment of the impact Hurricane Maria (HM) on drinking water quality in Puerto Rico (PR) by integrating targeted chemical analysis both inorganic (18 trace elements) and organic pollutants (200 micropollutants) with high-throughput quantitative toxicogenomics vitro biomarkers-based toxicity assays. Average concentrations 14 detected elements 20 micropollutants showed elevation after HM. Arsenic, sucralose, perfluorooctanoic acid (PFOA),...
Classically, one can increase the titer of an agglutinating or first antibody with antiglobulin second antibody. We have used avidin-biotin system in place to similarly extend agglutination by initial anticellular Erythrocytes were agglutinated adding succession, caproylamidobiotin-antibody, avidin, and extender (caproylamidobiotin-macromolecule). The macromolecules evaluated as extenders, order increasing potency, fibrinogen, albumin, succinylated polylysine, ribonuclease A. From...
This study has analysed the generation of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine adduct [M1dG], a biomarker oxidative stress and lipid peroxidation, in breast fine-needle aspirate samples 22 patients with cancer, at different clinical stages, respect to 13 controls. The multivariate analysis show that M1dG was higher cases than controls (Mean Ratio (MR) = 5.26, 95% CI 3.16–8.77). Increased observed women tumour grade 3 pathological diameter 2 (MR...
Three N-acyl derivatives of biotinylethylenediamine were prepared: I, biotinylamidoethyl-3-(3-[125I]iodo-4-hydroxyphenyl)propionamide; II, biotinylamidoethyl-[3H]acetamide; and III, biotinylamidoethyl-3-(3,5-[125I]diiodo-4-hydroxyphenyl)propionamid e. Each compound was combined with a large excess avidin, yielding 1:1 molar complexes. Aside from small fraction each complex that dissociated more rapidly, the dissociation half-lives these complexes were: 41 days; 4.4 148 days. The iodo- (mono...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuperoxide oxidation: a novel route to aromatic 1,2-dicarboxylic acidsChariklia Sotiriou, Wenni Lee, and Roger W. GieseCite this: J. Org. Chem. 1990, 55, 7, 2159–2164Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/jo00294a033https://doi.org/10.1021/jo00294a033research-articleACS PublicationsRequest reuse permissionsArticle...
Air quality is a primary environmental concern in highly industrialised areas, with potential health effects children residing nearby. The Sarroch industrial estate Cagliari province, Sardinia Island, Italy, hosts the world's largest power plant and second European oil refinery petrochemical park. This produces complex mixture of air pollutants, including benzene, heavy metals polycyclic aromatic hydrocarbons. Thus, we conducted cross-sectional study to evaluate prevalence...
Chronic silica exposure has been associated to cancer and silicosis. Furthermore, the induction of oxidative stress generation reactive oxygen species have indicated play a main role in carcinogenicity respirable silica. Therefore, we conducted cross-sectional study evaluate prevalence 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, biomarker peroxidation lipids, nasal epithelium 135 silica-exposed workers, employed pottery, ceramic marble...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile anhydride synthesis using trichlorotrifluoroacetone hydrateSamy Abdel-Baky and Roger W. GieseCite this: J. Org. Chem. 1986, 51, 17, 3390–3391Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/jo00367a034https://doi.org/10.1021/jo00367a034research-articleACS PublicationsRequest reuse permissionsArticle Views517Altmetric-Citations43LEARN ABOUT...
Tobacco smoke has been shown to produce both DNA damage and epigenetic alterations. However, the potential role of in generating changes is largely underinvestigated human studies. We examined effects smoking on levels methylation genes for tumor protein p53, cyclin-dependent kinase inhibitor2A, hypermethylated-in-cancer-1 (HIC1), interleukin-6, Long Interspersed Nuclear Element type1, Alu retrotransposons blood 177 residents Thailand using bisulfite-PCR andpyrosequencing. Then, we analyzed...
A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry (GC/EC/NCI-HRMS) method was developed for quantitating N7-(2-hydroxyethyl)guanine (N7-HEG) with excellent sensitivity and specificity. [4,5,6,8-13C4]-N7-HEG synthesized, characterized, quantitated using HPLC/electrospray (HPLC/ESI-MS) so it could serve as an internal standard. After being converted to its corresponding xanthine derivatized pentafluorobenzyl (PFB) bromide twice, the PFB...
The goal of this study was the development N-terminal tags to improve peptide identification using high-throughput MALDI-TOF/TOF MS. Part 1 focused on influence derivatization intensities MALDI-TOF MS signals peptides. In part 2, various approaches for improvement fragmentation efficiency in are explored. We demonstrate that permanent cation tags, while significantly improving signal intensity mode, lead severe suppression MS/MS fragmentation, making these unsuitable analysis. present work,...