Jirong Long
A5101592761- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- Estrogen and related hormone effects
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Gut microbiota and health
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Endometrial and Cervical Cancer Treatments
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Genetic and phenotypic traits in livestock
- Bone health and osteoporosis research
Vanderbilt University Medical Center
2016-2025
Peking University
2025
Hunan University of Science and Technology
2025
Nanchong Central Hospital
2025
Capital Medical University
2025
Vanderbilt University
2015-2024
Vanderbilt-Ingram Cancer Center
2008-2024
National Cancer Institute
2011-2023
Division of Cancer Epidemiology and Genetics
2013-2023
Breast Cancer Research Foundation
2023
Abstract Motivation: An important question that has emerged from the recent success of genome-wide association studies (GWAS) is how to detect genetic signals beyond single markers/genes in order explore their combined effects on mediating complex diseases and traits. Integrative testing GWAS data with prior-knowledge databases proteome recently gained attention. These methodologies may hold promise for comprehensively examining interactions between genes underlying pathogenesis diseases....
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
Abstract It remains elusive whether some of the associations identified in genome-wide association studies prostate cancer (PrCa) may be due to regulatory effects genetic variants on CpG sites, which further influence expression PrCa target genes. To search for sites associated with risk, here we establish models predict methylation (N = 1,595) and conduct analyses risk (79,194 cases 61,112 controls). We identify 759 showing an association, including 15 located at novel loci. Among those 42...
The oral microbiome may help to maintain systemic health, including how it affects blood glucose levels; however, direct evidence linking the with diabetes is lacking.We compared profiles of 98 participants incident diabetes, 99 obese non-diabetics and 97 normal weight non-diabetics, via deep sequencing 16S rRNA gene.We found that phylum Actinobacteria was present significantly less abundant among patients than controls (p = 3.9 × 10-3 ); odds ratio (OR) 95% confidence interval (CI) 0.27...
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms are often specific to cell type 3,4 . Here, characterize the genetic contribution these across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases T2D. We identify 1,289 independent signals at significance ( P < 5 × 10 −8 ) map 611 loci, which 145...
Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most variants small to moderate effects and account only a proportion of the heritability T2D, suggesting that majority inter-person variation in this disease remains be determined. We conducted multistage, genome-wide association study (GWAS) within Asian Consortium Diabetes search T2D markers. From 590,887 SNPs genotyped 1,019 cases 1,710 controls selected from Chinese women Shanghai, we top...
Genetic factors play an important role in the etiology of both sporadic and familial breast cancer. We aimed to discover novel genetic susceptibility loci for conducted a four-stage genome-wide association study (GWAS) 19,091 cases 20,606 controls East-Asian descent including Chinese, Korean, Japanese women. After analyzing 690,947 SNPs 2,918 2,324 controls, we evaluated 5,365 replication 3,972 3,852 controls. Ninety-four were further 5,203 5,138 finally top 22 investigated up 17,423...
FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest potential roles of regulating food intake. The interactive relation among variants, dietary intake and body mass index (BMI) complex results from previous often small-scale humans are highly inconsistent. We performed large-scale analyses based on data 177 330 adults (154 439 Whites, 5776 African Americans 17 115 Asians) 40 to examine: (i) association between FTO-rs9939609 variant (or...