A5056119134- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Psychotherapy Techniques and Applications
- Nutritional Studies and Diet
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Colorectal Cancer Screening and Detection
- Research in Social Sciences
- Personality Disorders and Psychopathology
- Cardiac electrophysiology and arrhythmias
- Diet and metabolism studies
- Psychiatric care and mental health services
- Genetic Associations and Epidemiology
- Digital Mental Health Interventions
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Schizophrenia research and treatment
- Statistical Methods and Inference
- Nutrition, Genetics, and Disease
- Multiple and Secondary Primary Cancers
- Transplantation: Methods and Outcomes
- Statistical Methods and Bayesian Inference
- Liver Disease Diagnosis and Treatment
- Health, psychology, and well-being
- Counseling, Therapy, and Family Dynamics
Finnish Institute for Health and Welfare
2011-2025
UNSW Sydney
2015-2024
The University of Sydney
2024
National Institutes of Health
2009-2014
University of Basel
2011
Institute for Molecular Medicine Finland
2007-2009
Public Health Institute
2007
t has been suggested that vitamin D reduces the risk of type 2 diabetes.The finding deficiency is associated with impaired -cell function and insulin resistance in animals (1,2) humans (3,4) line hypothesis.In only cohort study publ i s h e d , n a k o f v m supplements was inversely development diabetes (5).Since intake covers part total available, purpose this to evaluate prediction serum 25-hydroxyvitamin (25OHD) on subsequent incidence. RESEARCH DESIGN AND METHODS -The population,...
Low vitamin D status has been suggested as a risk factor for type 2 diabetes. Although the epidemiologic evidence is scarce, recent studies have an association. The present study investigated relation of serum with diabetes incidence using pooled data from these cohorts.Two nested case-control studies, collected by Finnish Mobile Clinic in 1973-1980, were analysis. populations consisted men and women aged 40-74 years free at baseline. During follow-up period 22 years, 412 incident cases...
Background Insufficient evidence exists for a viable choice between long- and short-term psychotherapies in the treatment of psychiatric disorders. The present trial compares effectiveness one long-term therapy two therapies mood anxiety Method In Helsinki Psychotherapy Study, 326 out-patients with (84.7%) or disorder (43.6%) were randomly assigned to three groups (long-term psychodynamic psychotherapy, solution-focused therapy) followed up 3 years from start treatment. Primary outcome...
FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest potential roles of regulating food intake. The interactive relation among variants, dietary intake and body mass index (BMI) complex results from previous often small-scale humans are highly inconsistent. We performed large-scale analyses based on data 177 330 adults (154 439 Whites, 5776 African Americans 17 115 Asians) 40 to examine: (i) association between FTO-rs9939609 variant (or...
Abstract Objectives Shifting from animal-based to plant-based diets could reduce colorectal cancer (CRC) incidence. Currently, the impacts of these dietary shifts on CRC risk are ill-defined. Therefore, we examined partial substitutions red or processed meat with whole grains, vegetables, fruits a combination in relation Finnish adults. Methods We pooled five cohorts, resulting 43 788 participants aged ≥ 25 years (79% men). Diet was assessed by validated food frequency questionnaires at...
The incidence of early-onset breast cancer (< 50 years) has been increasing over the past decades with role modifiable, lifestyle-related risk factors remaining mostly unidentified. To investigate key lifestyle in trends (EOBC), we pooled data from six health studies Finland 1972–2015 and combined them Finnish Cancer Registry. cohort consisted 56,253 women 397 EOBCs. effects (hazard ratios) on EOBC average annual percent change (AAPC) were estimated using Poisson regression models. highest...
Studies on the association between plant foods and cerebrovascular diseases have given contradictory results suggesting existence of some effect-modifying factors. The present study determines whether consumption (i.e. fruits berries, vegetables, cereals) predicts a decreased disease incidence in population with low fruit vegetable high wholegrain intake. This cohort 3932 men women was based data from Finnish Mobile Clinic Health Examination Survey, conducted 1968–72. participants were 40–74...
Tobacco smoke is a known carcinogen, but the magnitude of smoking-related cancer risk depends on country-specific, generational smoking patterns. We quantified in relation to population-based cohort, 45 and Up Study (2006-2009) New South Wales, Australia. Cox proportional hazards regressions estimated adjusted hazard ratios (HR) by self-reported history at baseline for incident, primary cancers via linkage registry data 2013 death 2015. Among 229 028 participants aged ≥45 years, 18 475 5382...
OBJECTIVE Obesity, particularly visceral adiposity, is a major risk factor for type 2 diabetes. The commonly used obesity indicators, BMI, waist girth, and waist-to-hip ratio (WHR), have limited ability to measure the adipose tissue. Sagittal abdominal diameter (SAD) has been shown predict amount of fat. So far no study published on its diabetes occurrence. RESEARCH DESIGN AND METHODS We assessed compared prediction four indicators incidence in prospective based 5,168 participants from...
Abstract The population attributable fraction (PAF) is a useful measure for describing the expected change in an outcome if its risk factors are modified. Cohort studies allow researchers to assess predictive value of factor modification on incidence during certain follow‐up. Estimation PAF both mortality and morbidity cohort with censored survival data has been developed recent years. So far, however, censoring due death estimation ignored, resulting quantity which not relevant practice as...
Maarit Laaksosen psykologian väitöskirja ”Patient suitability for short-term and longterm psychotherapy” tarkastettiin Jyväskylän yliopistossa 17.12.2014. Vastaväittäjänä toimi professori emeritus Johannes Lehtonen (Itä-Suomen yliopisto) ja kustoksena Jarl Wahlström (Jyväskylän yliopisto).
Quantification of the impact exposure to modifiable risk factors on a particular outcome at population level is fundamental public health issue. In cohort studies, attributable fraction (PAF) used assess proportion that certain in given during time interval. This done by combining information about prevalence factor with estimates strength association between and outcome. case mortality, PAF demonstrates what mortality can be delayed follow-up time. However, literature carrying out...
The population attributable fraction (PAF) is a useful measure for quantifying the impact of exposure to certain risk factors on particular outcome at level. Recently, new model-based methods estimation PAF and its confidence interval different types outcomes in cohort study design have been proposed. In this paper, we introduce SAS macros implementing these illustrate their application with data example type 2 diabetes incidence.
Objectives. To present an interview‐based 7‐item Suitability for Psychotherapy Scale (SPS) created to evaluate suitability short‐ and long‐term therapy, assess its reliability, validity, prediction. Design. Reliability of the SPS was evaluated by measuring both repeatability agreement (cross‐sectional design). Validity criterion discriminating validity Prediction using a cohort study design. Methods. 326 psychiatric outpatients from Helsinki Study assessed at baseline with SPS, summary score...
Hyposalivation is a common adverse effect of anti-neoplastic therapy head and neck cancer, causing impaired quality life predisposition to oral infections. However, data on the effects hematopoietic stem cell transplantation (HSCT) salivary secretion are scarce. The present study determined stimulated whole-saliva flow rates in HSCT recipients comparison with healthy control group. Stimulated 228 allogeneic (134 males, 94 females; mean age, 43 yrs) were examined pre-HSCT 6, 12, 24 months...