Raymond Noordam
A5017309256- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Sleep and related disorders
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Lipid metabolism and disorders
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- Cardiovascular Disease and Adiposity
- Growth Hormone and Insulin-like Growth Factors
- Genetic and phenotypic traits in livestock
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
Leiden University Medical Center
2016-2025
Leiden University
2010-2024
National Center for Geriatrics and Gerontology
2016-2023
Erasmus MC
2013-2022
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Umeå University
2019-2020
Helmholtz Zentrum München
2020
GGD Amsterdam
2018
Apotheek Haagse Ziekenhuizen
2014-2017
Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations central (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) general (body [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms BMI 49 WHRadjBMI were used to conduct Mendelian randomization analyses in 14 prospective studies supplemented coronary heart (CHD) data...
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms are often specific to cell type 3,4 . Here, characterize the genetic contribution these across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases T2D. We identify 1,289 independent signals at significance ( P < 5 × 10 −8 ) map 611 loci, which 145...
Abstract Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism 1–7 . This detailed knowledge genetic determinants systemic has been pivotal for uncovering how pathways influence biological mechanisms and complex diseases 8–11 Here we present a genome-wide study 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up 136,016 participants from 33 cohorts. We identify...
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear (MT-nDNA). In CHARGEmtDNA+ Consortium, we studied associations mtDNA MT-nDNA with body mass index (BMI), waist-hip-ratio (WHR), glucose, insulin, HOMA-B, HOMA-IR, HbA1c. This 45-cohort collaboration comprised 70,775 (insulin) to 170,202 (BMI) pan-ancestry individuals. Validation imputation variants was followed single-variant gene-based...
Abstract Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these effects. To identify interacting with we performed genome-wide analyses of HDL cholesterol, LDL and triglyceride levels in up to 120,979 individuals European, African, Asian, Hispanic, Brazilian ancestry, follow-up suggestive associations an additional 131,012 individuals. We find four loci, in/near CLASP1 , LHX1 SNTA1 CNTNAP2 that are...