Usha Menon
A5081082018- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Endometriosis Research and Treatment
- RNA modifications and cancer
- PARP inhibition in cancer therapy
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Molecular Biology Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
University College London
2016-2025
MRC Clinical Trials Unit at UCL
2018-2025
University of South Florida
2011-2025
Aging Community Coordinated Enterprises and Supportive Services (United States)
2025
Access to Wholistic and Productive Living Institute
2025
KIIT University
2024
Medical Research Council
2009-2024
James Cook University Hospital
2016-2024
Menon International (United States)
2007-2024
Christian Health Association of Nigeria
2024
Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5 years. We designed this trial to establish the effect early detection by screening on ovarian mortality.
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
Polycomb group proteins (PCGs) are involved in repression of genes that required for stem cell differentiation. Recently, it was shown promoters PCG target (PCGTs) 12-fold more likely to be methylated cancer than non-PCGTs. Age is the most important demographic risk factor cancer, and we hypothesized its carcinogenic potential may referred by irreversibly stabilizing features. To test this, analyzed methylation status over 27,000 CpGs mapping ∼14,000 whole blood samples from 261...
Ovarian cancer has a high case-fatality ratio, with most women not diagnosed until the disease is in its advanced stages. The United Kingdom Collaborative Trial of Cancer Screening (UKCTOCS) randomised controlled trial designed to assess effect screening on mortality. This report summarises outcome prevalence (initial) screen UKCTOCS.Between 2001 and 2005, total 202 638 post-menopausal aged 50-74 years were randomly assigned no treatment (control; n=101 359); annual CA125 (interpreted using...
BackgroundOvarian cancer continues to have a poor prognosis with the majority of women diagnosed advanced disease. Therefore, we undertook UK Collaborative Trial Ovarian Cancer Screening (UKCTOCS) determine if population screening can reduce deaths due We report on ovarian mortality after long-term follow-up in UKCTOCS.MethodsIn this randomised controlled trial, postmenopausal aged 50–74 years were recruited from 13 centres National Health Service trusts England, Wales, and Northern Ireland....
Background:Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in United States. Risk prediction based on identifying germline mutations susceptibility genes could have a clinically significant impact reducing disease mortality.
Background Recent studies have shown that DNA methylation (DNAm) markers in peripheral blood may hold promise as diagnostic or early detection/risk for epithelial cancers. However, to date no study has evaluated the and predictive potential of such a large case control cohort on genome-wide basis. Principal Findings By performing DNAm profiling ovarian cancer cohort, we here demonstrate active significant impact pattern blood. Specifically, by measuring levels over 27,000 CpGs cells from 148...
Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations central (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) general (body [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms BMI 49 WHRadjBMI were used to conduct Mendelian randomization analyses in 14 prospective studies supplemented coronary heart (CHD) data...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
The aim of this study was to estimate the contribution deleterious mutations in RAD51B, RAD51C, and RAD51D genes invasive epithelial ovarian cancer (EOC) population a screening trial individuals at high risk cancer.
Purpose Early detection of ovarian cancer has great promise to improve clinical outcome. Patients and Methods Ninety-six serum biomarkers were analyzed in sera from healthy women patients with cancer, benign pelvic tumors, breast, colorectal, lung cancers, using multiplex xMAP bead-based immunoassays. A Metropolis algorithm Monte Carlo simulation (MMC) was used for analysis the data. Results training set, including 139 early-stage 149 late-stage 1,102 women, MMC cross validation identify an...
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best manage the risk of in syndrome. The Manchester International Consensus Group was convened April 2017 address this unmet need. aim develop clear and comprehensive guidance regarding management sequelae based on existing evidence expert opinion medical professionals patients.
Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates. Patients and Methods In United Kingdom Collaborative Trial Ovarian Screening, 46,237 women, age 50 years or older underwent incidence by using multimodal strategy (MMS) in which annual serum antigen 125 (CA-125) was with ovarian (ROCA). Women were triaged ROCA:...