A5059707543- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Organ and Tissue Transplantation Research
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Genital Health and Disease
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Maternal and fetal healthcare
- Circular RNAs in diseases
- Maternal and Perinatal Health Interventions
- CAR-T cell therapy research
- Genomics, phytochemicals, and oxidative stress
- Ovarian function and disorders
- Pregnancy-related medical research
- FOXO transcription factor regulation
- Immune Cell Function and Interaction
- Reconstructive Surgery and Microvascular Techniques
- Ectopic Pregnancy Diagnosis and Management
Imperial College London
2016-2025
Imperial College Healthcare NHS Trust
2014-2025
Hammersmith Hospital
2014-2024
University College London
2021-2024
University of London
2024
The London College
2016-2023
Charing Cross Hospital
2017-2023
Royal Marsden Hospital
2023
Royal Ottawa Mental Health Centre
2023
London Cancer
2022-2023
Endometrial cancer is the most common malignancy of lower female reproductive tract. The tumor suppressor FOXO1 downregulated in endometrial compared with normal endometrium but underlying mechanisms are not well understood. Using microRNA (miR) target prediction algorithms, we identified several miRs that potentially bind 3'-untranslated region transcripts. Expression profiling and malignant samples by quantitative real-time PCR Northern blot analysis revealed an inverse correlation between...
There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best manage the risk of in syndrome. The Manchester International Consensus Group was convened April 2017 address this unmet need. aim develop clear and comprehensive guidance regarding management sequelae based on existing evidence expert opinion medical professionals patients.
6000 Background: The role of secondary cytoreductive surgery in recurrent ovarian cancer (ROC) has been under debate for decades. A recent trial unselected patients (pts) failed to show an OS benefit. Methods: Pts with ROC and 1st relapse after 6+ months (mos) platinum-free interval (TFIp) were eligible if they presented a positive AGO-score (PS ECOG 0, ascites ≤500 ml, complete resection at initial surgery) prospectively randomized second-line chemotherapy alone vs. followed by the same...
Adoptive T cell immunotherapy is a promising treatment strategy for epithelial ovarian cancer (EOC). However, programmed death ligand‐1 (PD‐L1), highly expressed on EOC cells, interacts with death‐1 (PD‐1), causing immunosuppression. This study aims to block PD‐1/PD‐L1 interactions by delivering PD‐L1 siRNA, using various folic acid (FA)–functionalized polyethylenimine (PEI) polymers, SKOV‐3‐Luc and investigate the sensitization of cells killing. To enhance siRNA uptake into which over...
5501 Background: The role of secondary cytoreductive surgery in recurrent ovarian cancer (OC) has not been defined by level-1 evidence. Methods: Pts with OC and 1st relapse after 6+ mos platin-free interval (TFIp) were eligible if they presented a positive AGO-score (PS ECOG 0, ascites ≤500 ml, complete resection at initial surgery) randomized to 2 nd -line chemotherapy alone vs followed chemo. Chemo regimens selected according the institutional standard. We report here results predetermined...
Survival from ovarian cancer (OC) is improved with surgery, but surgery can be complex and tumour identification, especially for borderline tumours (BOT), challenging. The Rapid Evaporative Ionisation Mass Spectrometric (REIMS) technique reports tissue histology in real-time by analysing aerosolised during electrosurgical dissection. Aerosol produced diathermy of tissues was sampled the REIMS interface. Histological diagnosis mass spectra featuring lipid species populated a reference...
RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated expression the protein in hepatocellular lung cancers correlated with adverse prognosis. associates interactome that enriched for oncogenic transcripts. Here we explore role epithelial ovarian cancer, a disease characterized by rapid acquisition resistance to chemotherapy through induction pro-survival signalling. We show,...
The ErbB network is dysregulated in many solid tumors. To exploit this, we have developed a chimeric Ag receptor (CAR) named T1E28z that targets several pathogenetically relevant dimers. coexpressed with cytokine 4αβ (combination termed T4), enabling the selective expansion of engineered T cells using IL-4. Human T4(+) exhibit antitumor activity against ErbB(+) cancer types. However, receptors are also expressed healthy tissues, raising concerns about toxic potential. In this study,...
Gender dysphoria, defined as the persistent discomfort with one's gender identity or biological sex, affects between 0.5 and 1.4% of adult males.1 Treatment aims at congruence, to allow those who experience it find comfort within their gendered self, which optimises psychological wellbeing self-fulfilment.2 Although many experiencing dysphoria require partial treatment social transition, others only following surgical intervention change external genitalia sexual characteristics....
Correct characterisation of ovarian tumours is critical to optimise patient care. The purpose this study evaluate the diagnostic performance International Ovarian Tumour Analysis (IOTA) logistic regression model (LR2), ultrasound Simple Rules (SR), Risk Malignancy Index (RMI) and subjective assessment (SA) for preoperative adnexal masses, when ultrasonography performed by examiners with different background training experience. A 2-year prospective multicentre cross-sectional study....
Treatment for patients with recurrent ovarian cancer has been mainly based on systemic therapy. The role of secondary cytoreductive surgery is unclear.We randomly assigned who had a first relapse after platinum-free interval (an during which no platinum-based chemotherapy was used) 6 months or more to undergo and then receive alone. Patients were eligible if they presented positive Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) score, defined as an Eastern Cooperative Oncology Group...
Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined capacity rapid evaporative ionization mass spectrometry (REIMS), also known as intelligent knife (iKnife), to discriminate between healthy, preinvasive, invasive tissue. Cervical tissue samples were collected from women with human papilloma virus (HPV) ± intraepithelial neoplasia (CIN), or cancer. A handheld diathermy device generated...
Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction copy-number alterations HGSOC are not fully understood. In current study, we confirm that TLS-high patients show significantly better progression-free survival (PFS). We presence tumors B cell maturation cytotoxic tumor-specific T activation proliferation. addition, loss IL15 CXCL10 may limit...