A5063966287- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Gene expression and cancer classification
- Advanced Proteomics Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Gestational Trophoblastic Disease Studies
- Advanced Biosensing Techniques and Applications
- Ectopic Pregnancy Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Bioinformatics and Genomic Networks
- Venous Thromboembolism Diagnosis and Management
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Diagnosis and Treatment of Venous Diseases
- Chemotherapy-related skin toxicity
Bharati Vidyapeeth Deemed University
2024
Imperial College London
2002-2023
Hammersmith Hospital
2010-2023
The University of Texas MD Anderson Cancer Center
2009-2023
Center for Systems Biology
2023
National Institute of Technology Warangal
2023
Northampton General Hospital NHS Trust
2016-2022
Northampton General Hospital
2016-2021
Charing Cross Hospital
2002-2020
Imperial College Healthcare NHS Trust
2009-2020
Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and relatedness to other cancer subtypes, 28 MBCs were compared with common using comparative genomic hybridization, transcriptional profiling, reverse-phase protein arrays sequencing for mutations. showed unique DNA copy number aberrations cancers. PIK3CA mutations detected in 9 19 (47.4%) versus 80 232 hormone receptor-positive (34.5%; P...
BackgroundAdjuvant trastuzumab significantly improves outcomes for patients with HER2-positive early breast cancer. The standard treatment duration is 12 months but shorter could provide similar efficacy while reducing toxicities and cost. We aimed to investigate whether 6-month adjuvant non-inferior the 12-month regarding disease-free survival.MethodsThis study an open-label, randomised phase 3 non-inferiority trial. Patients were recruited from 152 centres in UK. randomly assigned cancer,...
Abstract Introduction The lack of large panels validated antibodies, tissue handling variability, and intratumoral heterogeneity potentially hamper comprehensive study the functional proteome in non-microdissected solid tumors. purpose this was to address these concerns demonstrate clinical utility for analysis proteins breast tumors using reverse phase protein arrays (RPPA). Methods Herein, 82 antibodies that recognize kinase steroid signaling effectors were RPPA. Intraslide interslide...
Abstract Purpose: In part A, the aim was to define maximum tolerated dose (MTD) of hydrogen sulfate (Hyd-Sulfate) oral capsule formulation mitogen-activated protein kinase inhibitor AZD6244 (ARRY-142886). B, compare pharmacokinetic profile new Hyd-Sulfate with initial free-base suspension and further characterize pharmacodynamic efficacy formulation. Experimental Design: 30 patients received escalating doses twice daily. 29 were randomized a single or suspension, followed by washout, then...
Patients with high-risk (International Federation of Gynecology and Obstetrics score ≥ 7) gestational trophoblastic neoplasia (GTN) frequently receive etoposide, methotrexate, dactinomycin alternating weekly cyclophosphamide vincristine (EMA/CO). Between 1979 1995, overall survival (OS) this regimen at our institute was 85.4% a significant proportion early deaths (< 4 weeks). Here, we determine whether rates have improved in more recent patient cohort (1995 to 2010).Patients receiving EMA/CO...
To examine the androgen receptor (AR) levels in breast cancer and to assess impact of AR expression on patient outcomes.Reverse-phase protein arrays were used measure a mass spectroscopy-based approach was detect PIK3CA mutations. Means SDs generated for levels. Linear regression models determine if differed by tumor subtype mutation status. Two-sample t tests identify pair-wise differences. Survival probabilities estimated with use Kaplan-Meier product log-rank test.The median age 59 years...
Ovarian cancer frequently acquires resistance to platinum chemotherapy, representing a major challenge for improving patient survival. Recent work suggests that resistant clones exist within larger drug-sensitive cell population prior implying is selected rather than generated by treatment. We sought compare clinically derived, intrapatient paired models of initial response and subsequent relapse define molecular determinants evolved resistance. Transcriptional analysis matched line series...
Clinical resistance to chemotherapy is a frequent event in cancer treatment and closely linked poor outcome. High-grade serous (HGS) ovarian characterized by p53 mutation high levels of genomic instability. Treatment includes platinum-based initial response rates are high; however, frequently acquired, at which point options largely palliative. Recent data indicate that platinumresistant clones exist within the sensitive primary tumor presentation, implying resistant cell selection after...
Purpose Malignant ovarian germ cell tumors are rare and knowledge about prognostic parameters currently is limited. This study was undertaken to evaluate long-term outcome of patients with malignant (MOGCTs) after chemotherapy assess parameters. Patients Methods A total 113 stage IC IV MOGCTs were included into this retrospective study. treated at two large regional cancer centers between 1977 2003. Results Ten-year recurrence-free overall survival rates 82% 81%, respectively. 20 experienced...
We studied the expression levels of cyclins B1, D1, and E1 implications cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables transcriptional profiling.The were quantified 779 tumors 53 cell lines using reverse phase protein arrays and/or profiling.Whereas was a specific marker triple-negative basal-like tumors, B1 occurred poor prognosis hormone receptor-positive, luminal B cancers. Cyclin D1 normal-like Breast subgroups integrated...
Abstract Aberrations in oncogenes and tumor suppressors frequently affect the activity of critical signal transduction pathways. To analyze systematically relationship between activation status protein networks other characteristics cancer cells, we did reverse phase array (RPPA) profiling NCI60 cell lines for total expression activation-specific markers signaling extend scope study, merged those data with previously published RPPA results NCI60. Integrative analysis expanded set revealed...
To retrospectively evaluate embolotherapy of bleeding residual uterine vascular malformations in patients with gestational trophoblastic tumors.Fourteen were treated over the past 20 years. Embolizations performed a common femoral artery approach. Duplex ultrasonography was before and after embolization to document vascularity. The technique materials used for each embolization, control hemorrhage, need repeat complications, outcome subsequent pregnancies assessed.Hemorrhage controlled 11 14...
Neo-angiogenesis is a hallmark of cancer. The aim this study was to test the hypothesis, in prospective patient cohort, that low-risk gestational trophoblastic neoplasia (LR-GTN) uterine artery pulsatility index (UAPI), measure tumour vascularity, can predict resistance methotrexate chemotherapy (MTX-R).286 LR-GTN patients (Charing Cross Hospital (CXH) score 0-8, or FIGO 0-6) were treated with between January 2008 and June 2011 at CXH. During staging investigations, underwent Doppler...