A5100373260- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Renal Diseases and Glomerulopathies
- Melanoma and MAPK Pathways
- Chronic Lymphocytic Leukemia Research
- Helicobacter pylori-related gastroenterology studies
- Synthesis of Tetrazole Derivatives
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Platelet Disorders and Treatments
- Computational Drug Discovery Methods
- Vasculitis and related conditions
- Eosinophilic Esophagitis
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- Animal Genetics and Reproduction
- Chronic Kidney Disease and Diabetes
- Acute Lymphoblastic Leukemia research
- PI3K/AKT/mTOR signaling in cancer
- Systemic Sclerosis and Related Diseases
- Cutaneous Melanoma Detection and Management
The University of Texas MD Anderson Cancer Center
2011-2025
Hunan Normal University
2019-2025
Ministry of Education of the People's Republic of China
2023-2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2022-2025
Guangzhou University
2025
Second Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2019-2024
Central South University
2008-2024
Bengbu Medical College
2024
Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during past decades. Experimental observations have involved intestinal microbiota in susceptibility to MI mice; however, humans, identifying whether translocation gut bacteria systemic circulation contributes events post-MI remains a major challenge.Here, we carried out metagenomic analysis characterize cohort 49 healthy control individuals, 50 stable coronary disease...
Abstract Currently available human tumour cell line panels consist of a small number lines in each lineage that generally fail to retain the phenotype original patient tumour. Here we develop culture medium enables us routinely establish from diverse subtypes ovarian cancers with >95% efficiency. Importantly, 25 new described here genomic landscape, histopathology and molecular features tumours. Furthermore, profile drug response these correlate distinct groups primary tumours different...
Complications of peptic ulcer disease (PUD) are common in China. Population-based estimates the prevalence PUD needed to quantify and characterize population at risk these complications.As part a large epidemiological study, 3,600 randomly selected residents Shanghai (aged 18-80 years) were asked undergo endoscopy provide blood samples for Helicobacter pylori serology. All participants also completed general information questionnaire Chinese versions reflux (RDQ) Rome II questionnaire....
PurposeThe pathophysiological mechanisms underlying migraine remain elusive, with oxidative stress hypothesized as a potential etiological factor. The Oxidative Balance Score (OBS) is comprehensive tool for assessing the impact of diet and lifestyle on stress, thereby gauging an individual's overall antioxidant capacity. In this cross-sectional study, we explored correlation between OBS prevalence among cohort US adults.MethodsWe analyzed data from 6195 participants aged 20 years above,...
Surgical removal of primary tumors reverses tumor-mediated immune suppression in pre-clinical models with metastatic disease. However, how cytoreductive surgery the setting modulates responses patients, especially context checkpoint therapy (ICT), is not understood. We report first prospective, pilot, non-comparative clinical trial (NCT02210117) to evaluate feasibility, benefits, and immunologic changes combining three different ICT-containing strategies or biopsy for patients clear cell...
To determine whether functional proteomics improves breast cancer classification and prognostication can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane anthracycline-taxane-based systemic therapy (NST). Reverse phase protein array (RPPA) using 146 antibodies to proteins relevant was applied three independent tumor sets. Supervised clustering identify subgroups prognosis surgical excision specimens from a training set (n = 712) validated on test 168) two...
Abstract Aberrations in oncogenes and tumor suppressors frequently affect the activity of critical signal transduction pathways. To analyze systematically relationship between activation status protein networks other characteristics cancer cells, we did reverse phase array (RPPA) profiling NCI60 cell lines for total expression activation-specific markers signaling extend scope study, merged those data with previously published RPPA results NCI60. Integrative analysis expanded set revealed...
The epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by Montreal Definition. This study aimed determine prevalence symptom-defined GERD across five regions China, and investigate variables associated with GERD.A representative sample 18 000 adults (aged 18-80 years) were selected equally from rural urban areas in each region (n = 1800). According Definition, is present when mild symptoms heartburn and/or...
Abstract Purpose: Recent studies suggested that AKT activation might confer poor prognosis in acute myelogenous leukemia (AML), providing the rationale for therapeutic targeting of this signaling pathway. We, therefore, explored preclinical and clinical anti-AML activity an oral inhibitor, MK-2206. Experimental Methods: We first studied effects MK-2206 human AML cell lines primary specimens vitro. Subsequently, we conducted a phase II trial (200 mg weekly) adults requiring second salvage...
The biology and diversity of glomerular parietal epithelial cells (PECs) are important for understanding podocyte regeneration crescent formation. Although protein markers have revealed the morphological heterogeneity PECs, molecular characteristics PEC subpopulations remain largely unknown. Here, we performed a comprehensive analysis PECs using single-cell RNA sequencing (scRNA-seq) data. Our identified five distinct subpopulations: PEC-A1, PEC-A2, PEC-A3, PEC-A4 PEC-B. Among these...
Objective. Gastroesophageal reflux disease (GERD) is thought to be less prevalent in China than Western countries. However, essential population-based endoscopy data are lacking for this country. Material and methods. As part of a wider study, 3600 individuals selected randomly from the Shanghai region were asked undergo endoscopy. Participants completed general information questionnaire Chinese version Reflux Disease Questionnaire. When sufficient numbers available, associations assessed...
Protein extraction from formalin-fixed paraffin-embedded (FFPE) tissues is challenging due to extensive molecular crosslinking that occurs upon formalin fixation. Reverse-phase protein array (RPPA) a high-throughput technology, which can detect changes in levels and functionality numerous tissue cell sources. It has been used evaluate expression mainly frozen preparations or FFPE-based studies of limited scope. Reproducibility reliability the technique FFPE samples not yet demonstrated...
Previous studies suggest a potential therapeutic role for mTOR inhibition in lymphoid malignancies. This single-center phase I/II study was designed to test the safety and efficacy of inhibitor everolimus combination with HyperCVAD chemotherapy relapsed/refractory acute lymphoblastic leukemia (ALL).Twenty-four patients were treated; 15 received 5 mg/day 9 10 HyperCVAD.The median age 25 years (range, 11-64) number prior treatments 2 1-7). Grade 3 mucositis dose-limiting toxicity maximum...
The incidence of hemorrhagic fever with renal syndrome (HFRS) in Qingdao, China was three times higher than that the average national level. Here we characterized epidemiology, ecological determinants and pathogen evolution HFRS Qingdao during 2007-2015. In this longitudinal study, a total 1846 patients 41 HFRS-related deaths were reported. peaked once year fourth quarter. We built time series generalized additive model, found meteorological factors previous quarter could accurately predict...
Abstract Background Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in patients, in-depth study drug-resistant mechanism essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, studied its mechanisms vitro vivo. Results In cell research, we found that either or overexpression can activate Wnt/β-catenin EMT signaling pathway, may work through β-catenin/TWIST/TCF4 trimer. zebrafish confirmed similarity resistance,...