A5100665448- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Dysphagia Assessment and Management
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Cancer Treatment Studies
- Venous Thromboembolism Diagnosis and Management
- Cancer-related Molecular Pathways
- Kruppel-like factors research
Nanjing Medical University
2005-2025
Shanghai Ninth People's Hospital
2024-2025
Yancheng Third People's Hospital
2024-2025
Tianjin Medical University Cancer Institute and Hospital
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Tianjin Medical University
2018-2024
Dongyang People's Hospital
2014-2024
Wenzhou Medical University
2014-2024
Zhejiang University
2021-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2014-2024
The hypoxia-inducible factor 2α (HIF-2α) is a key oncogenic driver in clear cell renal carcinoma (ccRCC). Our first HIF-2α inhibitor PT2385 demonstrated promising proof of concept clinical activity heavily pretreated advanced ccRCC patients. However, was restricted by variable and dose-limited pharmacokinetics resulting from extensive metabolism to its glucuronide metabolite. Herein we describe the discovery second-generation PT2977 with increased potency improved pharmacokinetic profile...
Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, scheme based on phenotypic similarity between tumor cells normal has been successfully used to define subtypes; however, use cell types as reference by which classify solid tumors not widely emulated, in part due more limited epithelial differentiation compared with hematopoiesis. To provide better definition subtypes comprising breast...
Abstract Currently available human tumour cell line panels consist of a small number lines in each lineage that generally fail to retain the phenotype original patient tumour. Here we develop culture medium enables us routinely establish from diverse subtypes ovarian cancers with >95% efficiency. Importantly, 25 new described here genomic landscape, histopathology and molecular features tumours. Furthermore, profile drug response these correlate distinct groups primary tumours different...
Abstract Clear cell renal carcinomas (ccRCCs) display divergent clinical behaviours. Molecular markers might improve risk stratification of ccRCC. Here we use, based on genome-wide CpG methylation profiling, a LASSO model to develop five-CpG-based assay for ccRCC prognosis that can be used with formalin-fixed paraffin-embedded specimens. The classifier was validated in three independent sets from China, United States and the Cancer Genome Atlas data set. predicts overall survival patients...
Background:The progressive, multifactorial and multistep dynamic process of metastasis is the primary cause breast cancer (BC) lethality.PROX1 (Prospero-related homeobox 1), as a type transcription factor that plays key role in formation lymphatic vessels animal embryonic development, has been proven to promote or suppress variety malignant tumors.However, molecular mechanisms behind PROX1 induced metastases remain elusive.Methods: Changes expression clinical significance BC were evaluated...
Interaction between stromal cells and acute myeloid leukemia (AML) in bone marrow (BM) is known to contribute importantly chemoresistance disease recurrence. Therefore, disruption of a crosstalk AML BM microenvironment may offer promising therapeutic strategy for treatment. Here, we demonstrate that niche-like co-culture system, took up functional mitochondria from (BMSCs) inhibition such mitochondrial transfer by metformin, the most commonly prescribed drug type 2 diabetes mellitus,...
Abstract CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human malignancies, such as breast cancer. However, their application to other tumor types and intrinsic resistance mechanisms are still unclear. Here, we demonstrate that MYC amplification confers CDK4/6i bladder, prostate cancer cells. Mechanistically, binds the promoter of E3 ubiquitin ligase KLHL42 enhances its transcription, leading RB1 deficiency by inducing both phosphorylated total pRB1 ubiquitination...
A shift from oxygen phosphorylation to aerobic glycolysis was known as the Warburg effect and a characteristic of cancer cell metabolism facilitating metastasis. Mitochondrial calcium uniporter (MCU), key ion channel that mediates Ca2+ uptake into mitochondria, found promote progression However, its explicit role in shifting breast cells has not been defined.We evaluated MCU overexpression or knock-down on migration, invasion glucose metabolismin cells. dynamics were monitored with Rhod-2...
Epithelial ovarian cancer (EOC) is responsible for nearly 140,000 deaths worldwide each year. MicroRNAs play critical roles in development and progression. The function of microRNA miR-337–3p has been described various cancers. However, the biological role its molecular mechanisms underlying EOC initiation progression have not reported. Here, we reported that expression down-regulated tissues low correlated with advanced pathological grade patients. Ectopic inhibited proliferation induced...
Adenosine 3′,5′-monophosphate (cAMP) and cAMP-dependent protein kinase (PKA) are regulators of development in many organisms. Dictyostelium uses cAMP as an extracellular chemoattractant intracellular signal for differentiation. Cells that mutant adenylyl cyclase do not develop. Moderate expression the catalytic subunit PKA cyclase–null cells led to near-normal without detectable accumulation cAMP. These results suggest all signaling is effected through signals other than coordinate...
OBJECTIVES: The role of human papillomavirus (HPV) in Barrett's esophagus (BE) remains unclear. few studies that have previously investigated HPV and esophageal adenocarcinoma (EAC) or BE produced either negative data positive results doubtful clinical/etiological significance detected only low-risk types. We therefore prospectively determined the prevalence biologically active epithelium patients representing metaplasia–dysplasia–adenocarcinoma sequence. METHODS: DNA was estimated by nested...
MicroRNAs (miRNAs) are small noncoding RNA molecules which involved in tumorigenesis and development. To investigate their role primary laryngeal squamous cell carcinoma (LSCC), miRNA GeneChips were used to screen the differentially expressed miRNA, then validated by real-time quantitative PCR LSCC samples, we found that miR-375 was frequently downregulated tissues. The tumor-suppressive effect of determined vitro assays; through gain-of-function studies demonstrated can inhibit (SNU-48...
Pancreatic cancer is an aggressive malignancy with extremely poor prognosis. The human ether-a-go-go-related potassium channel (HERG1) a rapid delayed rectifier, which involved in many crucial cellular events. In this article, we find that HERG1 expression dramatically increased both pancreatic tissues and cell lines, significantly related to the development of cancer. silencing cancer-derived lines PANC-1 CFPAC-1 strongly inhibits their malignant capacity vitro as well tumorigenicity...
Abstract Muscle-invasive or metastatic bladder cancer (BCa) is associated with a very poor prognosis, and the underlying mechanism remains poorly understood. In this study, we demonstrate RASAL2, RAS GTPase-activating protein (RAS GAP), acts as tumor suppressor in BCa. First, RASAL2 was downregulated BCa specimens inversely correlated pathological grades clinical stages. Furthermore, observed that could inhibit stemness epithelial–mesenchymal transition (EMT) based on our gain-of-function...
Some patients with biliary atresia (BA) have associated anomalies. Our study aimed to investigate the incidence of BA-associated malformations in mainland China, and compare results those reported Western literature.Clinical data were collected retrospectively from five medical centers China. BA diagnosed confirmed by laparotomy intraoperative cholangiography liver biopsy. Cases divided into isolated type anomalies, including polysplenia, situs inversus, intestinal malrotation,...