Neil D. Merrett
A5045066173- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Palliative Care and End-of-Life Issues
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Economic and Financial Impacts of Cancer
- Genetic factors in colorectal cancer
- Childhood Cancer Survivors' Quality of Life
- Biliary and Gastrointestinal Fistulas
- Silicon Carbide Semiconductor Technologies
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal vascular conditions and treatments
- Genomics and Phylogenetic Studies
- Microscopic Colitis
Western Sydney University
2015-2024
Bankstown Lidcombe Hospital
2015-2024
University College London
2024
Liverpool Hospital
2004-2023
Sydney Local Health District
2022
Australia and New Zealand Banking Group
2022
Camden and Campbelltown Hospitals
2013-2022
UNSW Sydney
2004-2022
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
Objectives: Pancreatic cancer has a very poor prognosis, largely due to its propensity for early local and distant spread. Histopathologically, most pancreatic cancers are characterized by prominent stromal/fibrous reaction in around tumor tissue. The aims of this study were determine whether (1) the cells responsible formation stromal human activated stellate (PSCs) (2) an interaction exists between PSCs that may facilitate invasion tumor. Methods: Serial sections tissue stained desmin...
Current adjuvant therapies for pancreatic cancer (PC) are inconsistently used and only modestly effective. Because a high proportion of patients who undergo resection PC likely harbor occult metastatic disease, any trials assessing such as radiotherapy directed at locoregional disease significantly underpowered. Stratification based on the probability (and volume) residual could play an important role in design future clinical radiotherapy.We assessed relationships between margin...
BackgroundCurrent staging methods for pancreatic cancer (PC) are inadequate, and biomarkers to aid clinical decision making lacking. Despite the availability of serum marker carbohydrate antigen 19.9 (CA19.9) over two decades, its precise role in management PC is yet be defined, as a consequence, it not widely used.MethodsWe assessed relationship between perioperative CA19.9 levels, survival adjuvant chemotherapeutic responsiveness cohort 260 patients who underwent operative resection...
Abstract Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote restrain disease progression. Here, we interrogate how cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence a p53-driven hierarchy, where with gain-of-function (GOF) mutant educate dominant population CAFs that establish pro-metastatic environment for GOF null alike. also demonstrate educated by may be reprogrammed either or...
Abstract The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance this crosslinking and stabilizing fibrillar collagens its known role tumor desmoplasia. Using small-molecule drug-design approaches, we generated validated PXS-5505, first-in-class highly selective potent pan-lysyl inhibitor. We demonstrate vitro vivo that inhibition decreases chemotherapy-induced pancreatic desmoplasia stiffness, reduces cancer cell invasion metastasis,...
Abstract International comparison of liver cancer survival has been hampered due to varying standards and degrees for morphological verification differences in coding practices. This article aims compare across the Cancer Benchmarking Partnership's (ICBP) jurisdictions whilst trying ensure that estimates are comparable through a range sensitivity analyses. Liver incidence data from 21 7 countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway United Kingdom) were obtained...
ABSTRACT Silver in its ionic form (Ag + ), but not the bulk metal 0 is toxic to microbial life forms and has been used for many years treatment of wound infections. The prevalence bacterial resistance silver considered low due nonspecific nature toxicity. However, recent increased use as an antimicrobial agent medical, consumer, industrial products raised concern that widespread may emerge. Pseudomonas aeruginosa a common pathogen produces pyocyanin, redox toxin reductant molecular oxygen...
The return of research results (RoR) remains a complex and well-debated issue. Despite the debate, actual data related to experience giving individual back, impact these may have on clinical care health outcomes, is sorely lacking. Through work Australian Pancreatic Cancer Genome Initiative (APGI) we: (1) delineate pathway back patient where actionable were identified; (2) report utilisation returned. Using this experience, we discuss barriers opportunities associated with comprehensive...
Introduction Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of disease highlight need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC). Methods The ICBP SURVMARK-2 project, a platform international comparisons survival, collected cases diagnosed 1995 to 2014, followed until 31 st December 2015, registries covering seven participating countries with...
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups PanNETs, termed T1, T2 T3, distinct patterns methylation. The T1 subgroup was enriched for functional ATRX, DAXX MEN1 wild-type genotypes. contained mutations in recurrent chromosomal losses half genome no association between regions loss levels. were larger had lower MGMT gene body, which showed positive...
OBJECTIVES: The role of human papillomavirus (HPV) in Barrett's esophagus (BE) remains unclear. few studies that have previously investigated HPV and esophageal adenocarcinoma (EAC) or BE produced either negative data positive results doubtful clinical/etiological significance detected only low-risk types. We therefore prospectively determined the prevalence biologically active epithelium patients representing metaplasia–dysplasia–adenocarcinoma sequence. METHODS: DNA was estimated by nested...
Objective People diagnosed with pancreatic cancer have the worst survival prognosis of any cancer. No previous research has documented supportive care needs this population. Our objective was to describe people's and use support services examine whether these differed according or not patients had undergone surgical resection. Methods Queensland ampullary (n = 136, 54% those eligible) completed a survey, which assessed 34 across five domains (Supportive Care Needs Survey-Short Form) health...