Ellie T. Y. Mok
A5014469661- Pancreatic and Hepatic Oncology Research
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Occupational and environmental lung diseases
- PI3K/AKT/mTOR signaling in cancer
- Neonatal Respiratory Health Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Microbial metabolism and enzyme function
- Diabetes and associated disorders
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- Melanoma and MAPK Pathways
- Biosensors and Analytical Detection
- Trypanosoma species research and implications
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Caveolin-1 and cellular processes
- Cell Adhesion Molecules Research
Garvan Institute of Medical Research
2022-2024
The Kinghorn Cancer Centre
2022-2024
St Vincent's Clinic
2024
UNSW Sydney
2024
University of Technology Sydney
2021
Asbestos Diseases Research Institute
2017
The University of Sydney
2017
The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays crucial role shaping their progression. Many desmoplastic including breast cancer involve significant accumulation type I collagen. However, recently it has become clear precise distribution organisation molecules such as collagen equally important abundance. Cancer-associated fibroblasts (CAFs) coexist within tissues play both pro- anti-tumourigenic roles through remodelling...
Abstract The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance this crosslinking and stabilizing fibrillar collagens its known role tumor desmoplasia. Using small-molecule drug-design approaches, we generated validated PXS-5505, first-in-class highly selective potent pan-lysyl inhibitor. We demonstrate vitro vivo that inhibition decreases chemotherapy-induced pancreatic desmoplasia stiffness, reduces cancer cell invasion metastasis,...
Abstract Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells. Dysregulation miRNA expression and function has been linked to a variety diseases including cancer. They play complex role in cancers, having both tumour suppressor promoter properties. In addition, single can be involved regulating several mRNAs many miRNAs regulate mRNA, therefore assessing these roles is essential better understanding cancer initiation development. Pancreatic leading cause death...
Abstract In recent decades, the role of tumor biomechanics on cancer cell behavior at primary site has been increasingly appreciated. However, effect latter stages metastatic cascade, such as seeding secondary sites and outgrowth remains underappreciated. This work sought to address this in context triple negative breast (TNBC), a type known aggressively disseminate all disease progression. Using mechanically tuneable model systems, mimicking range stiffness's typically found within tumors,...
Abstract The exponential amplification reaction (EXPAR) is an emerging isothermal nucleic acid method with high potential for molecular diagnostics due to its nature and efficiency. However, the use of EXPAR limited by levels non-specific amplification. Hence, methods that can improve specificity are desired facilitate widespread adoption in practice. Herein, we proposed a strategy performance using enhancers. Eight small molecules were investigated, including ethylene glycol, propylene...
Summary Although c-Jun N-terminal Kinase (JNK) represents an attractive anti-cancer target, its pleiotropic functionality limits the use of direct JNK inhibitors. Here, we identify a distinct subcellular pattern activity as therapeutic vulnerability in breast cancer, where cytoplasmic predicts poor survival outcomes, is elevated triple-negative cancers (TNBC) and essential for metastatic outgrowth. Mechanistic analyses reveal acts through multiple mechanisms, with downstream targets involved...
Malignant pleural mesothelioma (MPM) is associated with asbestos exposure. Asbestos can induce chronic inflammation which in turn lead to silencing of tumour suppressor genes. Wnt signaling pathway be affected by and aberrantly activated many cancers including colon MPM. SFRP genes are antagonists pathway, s potential suppressors colon, gastric, breast, ovarian, lung mesothelioma. This study investigated the expression DNA methylation MPM cells lines without demethylation treatment....