A5102956561- Livestock Management and Performance Improvement
- Genetic and phenotypic traits in livestock
- Legionella and Acanthamoeba research
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Amoebic Infections and Treatments
- Effects of Environmental Stressors on Livestock
- Animal Nutrition and Health
- Estrogen and related hormone effects
- Food Industry and Aquatic Biology
- Parasitic Infections and Diagnostics
- Free Radicals and Antioxidants
- Agricultural Economics and Practices
- Agricultural Systems and Practices
- Computational Drug Discovery Methods
- Melanoma and MAPK Pathways
Kerala Veterinary and Animal Sciences University
2007
Govind Ballabh Pant University of Agriculture and Technology
2005-2006
Summary Although c-Jun N-terminal Kinase (JNK) represents an attractive anti-cancer target, its pleiotropic functionality limits the use of direct JNK inhibitors. Here, we identify a distinct subcellular pattern activity as therapeutic vulnerability in breast cancer, where cytoplasmic predicts poor survival outcomes, is elevated triple-negative cancers (TNBC) and essential for metastatic outgrowth. Mechanistic analyses reveal acts through multiple mechanisms, with downstream targets involved...
The current study recognizes the significance of estrogen receptor alpha (ERα) as a member nuclear protein family, which holds central role in pathophysiology breast cancer. ERα serves valuable prognostic marker, with its established relevance predicting disease outcomes and treatment responses.