A5057462908- Pluripotent Stem Cells Research
- Telemedicine and Telehealth Implementation
- Patient Satisfaction in Healthcare
- Nutrition and Health in Aging
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Williams Syndrome Research
- Estrogen and related hormone effects
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Breast Cancer Treatment Studies
- Hernia repair and management
- Pancreatitis Pathology and Treatment
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Reconstructive Surgery and Microvascular Techniques
- Urological Disorders and Treatments
- Congenital heart defects research
- Frailty in Older Adults
- Head and Neck Surgical Oncology
- Nursing Diagnosis and Documentation
- Stoma care and complications
- Tissue Engineering and Regenerative Medicine
- Microbial Community Ecology and Physiology
- Health and Wellbeing Research
Children's Medical Research Institute
2006-2025
The University of Sydney
2012-2025
Oregon Health & Science University
2021-2023
Westmead Institute for Medical Research
2019
Westmead Institute
2012
UNSW Sydney
2004
Bankstown Lidcombe Hospital
2004
Liverpool Hospital
2004
Objectives: Pancreatic cancer has a very poor prognosis, largely due to its propensity for early local and distant spread. Histopathologically, most pancreatic cancers are characterized by prominent stromal/fibrous reaction in around tumor tissue. The aims of this study were determine whether (1) the cells responsible formation stromal human activated stellate (PSCs) (2) an interaction exists between PSCs that may facilitate invasion tumor. Methods: Serial sections tissue stained desmin...
Background: Opportunities for care improvement exist within virtual care, which continues to emerge as an increasingly viable heath option. Problem: Competing priorities presented a challenge nurse leaders, resulting in modern solution optimize resources using care. Methods: A new model of delivery, the discharge (VDC) protocol, was established partnership between bedside nurses and team. Interventions: Using existing telehealth technology, delivered remote education patients on 30-bed...
There are no comprehensive management guidelines for pediatric blunt renal injury; therefore, we hypothesized that wide variation in care exists. We sought to describe contemporary of trauma and explore associations between clinical strategies adverse outcomes. retrospectively evaluated injury patients (younger than 18 years) treated at 11 level I centers from 2020 2022. categorized by the American Association Surgery Trauma grade (low, grades 1-3; high, 4-5) isolated versus polytrauma....
Peridinin-containing dinoflagellates have a highly reduced chloroplast genome, which is unlike that found in other containing organisms. Genome reduction appears to be the result of extensive transfer genes nuclear genome. Unusually believed remaining genome are on small DNA 'minicircles'. In this study we present comparison sets minicircle sequences from three dinoflagellate species. PCR was used amplify several minicircles Amphidinium carterae so homologous set gene-containing available...
The aim of this study is to evaluate the current state ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention how closely adheres national guidelines.Case series including retrospective records review (age > 18) treated at University California Davis Medical Center between January 2014 and August 2017. Patient related variables were analyzed. Patients that underwent a transfer care during treatment less than 3 months...
Objectives/Goals: Pediatric inguinal hernia (PIH) is a common diagnosis managed by pediatric surgeons. Patients typically present in the outpatient setting for evaluation. However, subset emergently with incarceration, which has higher risks. Our research aims to identify and address disparities access care of PIHR. Methods/Study Population: This study sequential multi-methods approach. First, we will perform retrospective cohort patients (ages 0–18) who have undergone PIHR at St Louis...
Human induced pluripotent stem cells (hiPSCs) possess the ability to differentiate into a multitude of cell and tissue types but display heterogeneous propensity differentiation specific lineage. Characterization transcriptome 11 hiPSC lines showed that activation MIXL1 at early stage correlated with higher efficacy in generating definitive endoderm advancing maturation derivatives. Enforced expression endoderm-inefficient hiPSCs enhanced differentiation, suggesting modulation key drivers...
// Heidi N. Hilton 1 , Tram B. Doan J. Dinny Graham Samantha R. Oakes 2,3 Audrey Silvestri Nicole Santucci Silke Kantimm Lily I. Huschtscha 4 Christopher Ormandy John W. Funder 5 Evan Simpson Elizabeth S. Kuczek 6 Peter Leedman 7 Wayne D. Tilley 8 Fuller George E. O. Muscat 9 and Christine L. Clarke Westmead Millennium Institute, Sydney Medical School – Westmead, University of Sydney, NSW, Australia 2 Cancer Research Program The Kinghorn Centre, Garvan Institute Research, Darlinghurst, 3 St...
Background Sarcopenia is prognostic for survival in patients with head and neck cancer (HNC). However, identification of this high-risk feature remains challenging without computed tomography (CT) imaging the abdomen or thorax. Herein, we establish sarcopenia thresholds at C3 level determine if associated HNC. Methods This retrospective cohort study was conducted consecutive a squamous cell carcinoma cross-sectional abdominal within 60 days prior to treatment. Measurement muscle area L3...
The GTF2IRD1 gene is of principal interest to the study Williams-Beuren syndrome (WBS). This neurodevelopmental disorder results from hemizygous deletion a region chromosome 7q11.23 containing 28 genes including GTF2IRD1. WBS thought be caused by haploinsufficiency certain dosage-sensitive within deleted region, and feature supravalvular aortic stenosis (SVAS) has been attributed reduced elastin ELN. Human genetic mapping data have implicated two related GTF2I in cause some key features WBS,...
GTF2IRD2 belongs to a family of transcriptional regulators (including TFII-I and GTF2IRD1) that are responsible for many the key features Williams-Beuren syndrome (WBS). Sequence evidence suggests arose in eutherian mammals by duplication divergence from gene encoding TFII-I. However, GTF2IRD2, most C-terminal domain has been lost replaced domesticated remnant an in-frame hAT-transposon mobile element. In this first experimental analysis function, we show transgenic expression each three...
Background: The COVID-19 pandemic has transformed health care delivery through the rise of telehealth solutions. Though telemedicine-based been identified as safe and feasible in postoperative care, data on initial surgical consultations preoperative setting are lacking. We sought to compare patient characteristics, anticipated downstream utilization, patient-reported experiences (PREs) for in-person versus conducted consultation encounters at a hernia abdominal wall center.
Scalp and cranial defects can occur as a result of cutaneous or bony malignancies, trauma, surgical intervention for intracranial tumors. Soft tissue reconstruction composite presents unique challenge given the relative inelasticity scalp, need tension free closure, convex shape cranium. An added complexity is found in patients with large defects, cerebrospinal fluid leak, prior failed reconstruction, infection, previous radiation. Methods materials skull have evolved significantly over...
Human induced pluripotent stem cells (hiPSC) possess the ability to differentiate into a multitude of cell and tissue types but display heterogeneous propensity differentiation specific lineage. Characterization transcriptome eleven hiPSC lines showed that activation MIXL1 at early stage correlated with higher efficacy in generating definitive endoderm advancing maturation derivatives. Enforced expression endoderm-inefficient hiPSCs enhanced differentiation, suggesting modulation key drivers...
Abstract Importance Sarcopenia, or diminished skeletal muscle mass, is prognostic for survival in patients with head and neck cancer (HNC). However, identification of this high-risk feature remains challenging without computed tomography (CT) images that capture the abdomen lower thorax. Objectives To (1) define sarcopenia thresholds at C3 vertebral level using previously established derived from abdominal CT imaging (2) determine if C3-defined associated HNC. Design, setting, participants...