Background:The progressive, multifactorial and multistep dynamic process of metastasis is the primary cause breast cancer (BC) lethality.PROX1 (Prospero-related homeobox 1), as a type transcription factor that plays key role in formation lymphatic vessels animal embryonic development, has been proven to promote or suppress variety malignant tumors.However, molecular mechanisms behind PROX1 induced metastases remain elusive.Methods: Changes expression clinical significance BC were evaluated...

Background: Ferroptosis is an iron-dependent programmed cell death process. Recent studies have found that ferroptosis inducers hold promising potential in the treatment of lung adenocarcinoma (LUAD). However, comprehensive analysis about prognostic value ferroptosis-related genes LUAD remains to be elucidated. Methods: The RNA sequencing data and corresponding clinical information were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. A total 259 extracted...

Aquaporins (AQPs), also called water channels, have been shown to functions in the migration, invasion, and proliferation of human breast tumor cells. Most AQP mRNA expression levels were tested by cell lines, mouse models, even tissues. However, individual AQPs different clinicopathologic characteristics prognostic values according kinds classifications cancer patients remains unclear.In current study, we used Oncomine database, Breast Gene-Expression Miner v4.1, Kaplan-Meier Plotter,...

The PINK1 gene encodes a serine/threonine protein kinase that localizes to mitochondria and has usually been considered protect cells from stress-induced mitochondrial dysfunction. mutations have observed lead autosomal recessive Parkinson's disease. However, the immunological prognostic roles of across cancers remain unclear.In current study, we used multiple databases, including Oncomine, PrognoScan, Kaplan-Meier Plotter, GEPIA, TIMER, cBioportal, investigate expression distribution its...

Breast cancer is the most common malignant tumor in women worldwide. However, advanced multidisciplinary therapy cannot rescue mortality of high-risk breast metastasis. Ferroptosis a newly discovered form regulating cell death that related to treatment, especially eradicating aggressive malignancies are resistant traditional therapies. prognostic value ferroptosis-related gene remains unknown.In this study, total 1,057 RNA expression data with clinical and follow-up information were...

Background The therapeutic effect of immune checkpoint inhibitors on tumors is not only related to CD8+ effector T cells but also sufficiently CD4+ helper (T H ) cells. characteristics breast cancer, including gene and tumor-infiltrating lymphocytes, have become significant biomarkers for predicting prognosis immunotherapy response in recent years. Methods Breast cancer samples from Cancer Genome Atlas (TCGA) database triple-negative (TNBC) GSE31519 the Gene Expression Omnibus (GEO) were...

Cancer stem cells (CSCs) are regarded as the root of tumor recurrence and distant metastasis, well major cause resistance to conventional cancer therapies. Elucidating mechanism regulating CSCs is great significance for development CSCs-targeting therapy strategies. YAP/TAZ identified key regulators CSCs-related traits on breast cells; however, upstream regulatory Hippo kinases cascade involved in remains elusive. In this study, we found that low expression RICH1 was associated with poor...

Triple negative breast cancer (TNBC) is characterized by poor prognosis and a lack of effective therapeutic agents owing to the absence biomarkers. A high abundance tumor-infiltrating regulatory T cells (Tregs) was associated with worse in malignant disease. Exploring association between Treg cell infiltration TNBC will provide new insights for understanding immunosuppression may pave way developing novel immune-based treatments. Patients from TCGA were divided into Treg-high (Treg-H)...

Background: In the absence of targeted therapy or clear clinically relevant biomarkers, neoadjuvant chemotherapy (NAC) is still standard systemic for breast cancer. Among many biomarkers predicting efficacy NAC, immune-related such as genes and tumor-infiltrating lymphocytes (TILs), play a key role. Methods: We analyzed gene expression from several datasets in Gene Expression Omnibus (GEO) database evaluated relative proportion immune cells using CIBERSORT method. addition, mIHC/IF detection...

S100 family is made up of at least 20 calcium-binding proteins which are involved in many cellular processes. The prognostic values individual member ovarian cancer patients still unknown. In this study, we performed a detailed cancer. mRNA expression levels various cancers were analyzed via the Oncomine, and protein-protein interaction network was String. evaluated Kaplan-Meier Plotter. genes mutation cBioProtal. We observed that most overexpressed compared with normal tissues. survival...

Objective This study aimed to determine the association of asymptomatic sexually transmitted infections (STIs), including Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), genitalium, Chlamydia trachomatis, and herpes simplex virus type 2, with high-risk human papillomavirus (hrHPV) in cervical intraepithelial lesions neoplasms. Methods A total 320 hrHPV-positive 160 hrHPV-negative women were divided into high-grade squamous lesion (HSIL) + invasive cancer low-grade normal subgroups,...

Background Breast cancer progression has been gradually recognized as a bidirectional interaction between cells and tumor microenvironment including stroma cells, immune the dynamically altered ECM. However, there still lacks direct experimental evidences about how ECM properties modulate activities of cells. Method The transcriptomic data corresponding clinical information breast pawere obtained from TCGA. Patients were divided into ECM-high, ECM-median ECM-low groups based on ssGSEA scores...

The homeobox gene family, encoding a specific nuclear protein, is essential for embryonic development, differentiation, and homeostasis. role of the HOXB3 protein varies in different tumors. This study aims to explore breast cancer.Differentially expressed genes were screened by analyzing metastatic cancer chip data from TCGA GEO databases. function selected was also analyzed databases through molecular biology methods, such as qRT-PCR, western blot IF verify bioinformatics findings.Both...

Traditional classification that divided gliomas into glioblastoma multiformes (GBM) and lower grade (LGG) based on pathological morphology has been challenged over the past decade by improvements in molecular stratification, however, reproducibility diagnostic accuracy of glioma still remains poor. This study aimed to establish validate a novel nomogram for preoperative diagnosis GBM using integrated data combined with feasible baseline characteristics tests.

Abstract Patients with advanced breast cancer (BC) showed a higher incidence of regional and distant metastases. Sine oculis homeobox homolog 1 (SIX‐1) has been confirmed to be key tumorigenic metastatic regulator in BC progression. Yet, molecular mechanisms behind SIX‐1‐induced metastases remain largely unknown. Here we found that SIX‐1 was frequently up‐regulated correlated poor outcomes when tested human tissue microarray. Then, manipulated the expression by via shRNA‐mediated knockdown...

The 21‑gene recurrence score (RS) predicts the prognosis of patients with estrogen receptor (ER)‑positive, human epidermal growth factor 2 (HER2)‑negative early‑stage breast cancer and effectiveness adding adjuvant chemotherapy on basis endocrine therapy to avoid excessive chemotherapy. present study aimed analyze clinicopathological characteristics chemotherapeutic efficacy‑related target genes RS in hormone receptor‑positive China. prognostic value was also examined. In addition, this...

Background Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The ECM has been recognized as an important determinant of breast cancer progression prognosis. Recent studies have revealed a strong link between immune cell infiltration in variety tumor types. However, the landscape specific regulatory mechanisms microenvironment not fully understood. Methods Using genomic data clinical information patients obtained from Cancer Genome Atlas (TCGA) Gene Expression...

Metabolic pathways play an essential role in breast cancer. However, the of metabolism-related genes early diagnosis cancer remains unknown.In our study, RNA sequencing (RNA-seq) expression data and clinicopathological information from The Cancer Genome Atlas (TCGA) GSE20685 were obtained. Univariate cox regression least absolute shrinkage selection operator (LASSO) analyses performed on differentially expressed genes. Then, formula risk model was composed, score each patient calculated....

Growing evidence proved that signal transducer and activators of transcription (STAT) proteins are cytoplasmic factors known to play key roles in many cellular biological processes may be prognostic predictors some cancers. However, the role each STAT family members breast cancer (BRCA) is diverse controversial. This study aimed systematic mine significance immune infiltration member human BRCA.Based on The Cancer Genome Atlas (TCGA) database, we used Oncomine, Gene Expression Profiling...