A5100452617- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Cancer Treatment Studies
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Bone health and osteoporosis research
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Urinary and Genital Oncology Studies
- Gastrointestinal disorders and treatments
Heilongjiang Bayi Agricultural University
2025
Affiliated Hospital of Southwest Medical University
2022-2024
Beijing University of Technology
2024
Huadong Hospital
2022-2024
Fudan University
2015-2024
Jiangxi Science and Technology Normal University
2024
Yanbian University
2007-2024
Beijing Xuanwu Traditional Chinese Medicine Hospital
2024
China University of Mining and Technology
2024
Shanghai Mental Health Center
2024
Organic acids are key components that determine the taste and flavor of fruits play a vital role in maintaining fruit quality nutritive value. In this study, two cultivars passion Yellow (Passiflora edulis f. flavicarpa) purple edulis) were harvested at five different developmental stages (i.e., fruitlet, green, veraison, near-mature mature stage) from an orchard located subtropical region Fujian Province, China. The contents six organic quantified using ultra-performance liquid...
Background Whether intensity-modulated radiotherapy (IMRT) can enhance the efficacy of programmed death (PD)-1 inhibitors combined with anti-angiogenic therapy for hepatocellular carcinoma (HCC) is unclear. Therefore, we conducted this multicenter retrospective study to investigate combination PD-1 and IMRT. Methods From April 2019 March 2022, a total 197 patients HCC [combination IMRT (triple group), 54; plus (control 143] were included in our study. Propensity score matching (PSM) was...
We initiated this multicenter study to integrate important risk factors create a nomogram for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) clinician decision-making. Between April 2011 and March 2022, 2281 HCC patients with an HBV-related diagnosis were included. All randomly divided into two groups in ratio of 7:3 (training cohort, n = 1597; validation 684). The was built the training cohort via Cox regression model validated cohort. Multivariate analyses revealed that...
Abstract Background Although the diagnostic value of plasma heat-shock protein 90α (HSP90α) in hepatocellular carcinoma (HCC) has been previously reported, causal effect HSP90α levels on HCC prognosis remains largely unclear. To this extent, we sought to assess whether acts as a prognostic factor for patients. Methods A total 2150 patients were included retrospective study between August 2016 and July 2021. Plasma tested within week before treatment their association with was assessed....
Background: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common type of cancer worldwide. Its highly aggressive heterogeneous nature complex tumor microenvironment result in variable prognosis immunotherapeutic outcomes for patients with HNSCC. Neurotrophic factor-related genes (NFRGs) play an essential role development malignancies but have rarely been studied The aim this study was to develop a reliable prognostic model based on NFRGs assessing immunotherapy HNSCC...
TACE and with or without targeted immunotherapy are crucial comprehensive therapies for middle advanced HCC. However, a reasonable concise score is needed to evaluate combined systemic therapy in HCC treatment.The patients were grouped into two groups: training group (n = 778) (treated TACE) verification 333). The predictive value of baseline variables on overall survival was analyzed using COX model, easy-to-use ALR (AST Lym-R) scores. best cut-off AST Lym-R determined X-Tile software based...
The optimal local treatment for HCC with tumor diameter ≥ 5 cm is not well established. This research evaluated the effectiveness of external beam radiation therapy (EBRT) versus transcatheter arterial chemoembolization (TACE) cm.A total 1210 patients were enrolled in this study, including 302 and 908 that received EBRT TACE, respectively. Propensity score matching (PSM) was used to identify patient pairs similar baseline characteristics. Overall survival (OS) primary study endpoint.We...
Abstract The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to immunosuppressive tumor microenvironment and lack sufficient infiltration activated CD8+ T cells. Transforming (TME) from “cold” “hot” thus more likely potentiate effects ICIs is a promising strategy for cancer treatment. We found that selective BCL-2 inhibitor APG-2575 can enhance antitumor efficacy anti-PD-1 therapy syngeneic humanized CD34+ mouse models. Using single-cell RNA sequencing, we...
Pancreatic adenosquamous carcinoma (PASC) -a rare pathological pancreatic cancer (PC) type -has a poor prognosis due to high malignancy.To examine the heterogeneity of PASC, we performed single-cell RNA sequencing (scRNA-seq) profiling with sample tissues from healthy donor pancreas, an intraductal papillary mucinous neoplasm, and patient PASC.Of 9,887 individual cells, ten cell subpopulations were identified, including myeloid, immune, ductal, fibroblast, acinar, stellate, endothelial,...
D-chiro-inositol (DCI) is an isomer of inositol, abundant in many foods, such as beans and buckwheat, with insulin-sensitizing, anti-inflammatory, antioxidant effects. DCI has been used to relieve insulin resistance diabetes polycystic ovary syndrome combination inositol or D-pinitol. Here, we investigated the effect on aging stress C. elegans. We found that could prolong lifespan elegans by up 29.6 %. significantly delayed onset neurodegenerative diseases models decreased accumulation...
Preeclampsia (PE) is a severe pregnancy-induced disorder characterized by hypertension and proteinuria leading cause of perinatal maternal–fetal mortality morbidity in developing countries. Dysregulated human leukocyte antigen (HLA)-G was found placentas as well maternal sera from PE patients; however, the reason for this difference unknown. As accumulating evidence has confirmed that DNA methylation an important mechanism regulating gene expression, we sought to test hypothesis alteration...
Neoadjuvant chemotherapy has been widely used in locally advanced and inflammatory breast cancer. Generally, complete pathological response after neoadjuvant treatment predicts survival. Studies have shown that patient-derived organoids can be cancer research drug development. Therefore, we aimed to generate a living organoid biobank from biopsy samples predict the of patients chemotherapy. We generated receiving When patient received chemotherapy, were treated with similar drugs, thereby...
Abstract Background This study protocol specifies the primary research line and theoretical framework of 2023 Survey Psychology Behavior on Chinese Population. It aims to establish a database focused psychology behavior among residents through multicenter, large-sample cross-sectional survey provide strong data support for development in related fields. will track public’s physical psychological health more comprehensively systematically. Methods The was conducted from 20 June 31 August...
Transnasal endoscopic nasopharyngectomy (TEN) has become increasingly used for recurrent nasopharyngeal carcinoma (rNPC); however, there is no report on the definitive resectable contour TEN according to latest staging system carcinoma. The aim of this study was establish types rNPC.A total 101 rNPC patients underwent from January 2016 April 2019 at authors' institution. categorized into four types, which included type I (n=40) with resection nasopharynx and sinuses; II (n=10) lateral...
Based on TCGA, GTEx, and TIMER databases various bioinformatics analysis methods, the potential biological roles of cuprotosis-related genes in pancreatic cancer were deeply explored, a predictive model for patients was constructed. We downloaded RNA-Seq data clinicopathological 179 tissues 332 adjacent normal from TCGA GTEx databases. The differential expression tissue analyzed, LASSO regression algorithm used to construct prediction verify validity prediction. algorithm, composed three...
The emergence of sorafenib resistance has become a predominant impediment and formidable dilemma in the therapeutic approach for hepatocellular carcinoma (HCC). Although approval next-generation drugs as alternatives to is significant development, concurrent use inhibitors that target additional key molecular pathways remains an effective strategy mitigate acquisition resistance. Here, we identified Glutathione S-Transferase Alpha 1 (GSTA1) critical modulator (SR) (HCC) based on our findings...