A5046914975- ZnO doping and properties
- Geochemistry and Geologic Mapping
- Ga2O3 and related materials
- GaN-based semiconductor devices and materials
- Geoscience and Mining Technology
- Geological and Geochemical Analysis
- Autophagy in Disease and Therapy
- Geochemistry and Geochronology of Asian Mineral Deposits
- earthquake and tectonic studies
- Reproductive Biology and Fertility
- Lipid metabolism and biosynthesis
- Epilepsy research and treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced Photocatalysis Techniques
- Genetics and Neurodevelopmental Disorders
- HIV Research and Treatment
- Microbial bioremediation and biosurfactants
- RNA Research and Splicing
- Acute Myocardial Infarction Research
- Wound Healing and Treatments
Southeast University
2022-2025
State Key Laboratory of Digital Medical Engineering
2022-2025
Digital Science (United States)
2025
Ningde Normal University
2023-2024
First Affiliated Hospital Zhejiang University
2015-2024
Dalian University of Technology
2022-2024
Southern Medical University
2024
Nanfang Hospital
2024
Zhejiang University
2006-2023
Xiamen University
2023
Immune checkpoint inhibition targeting the PD-1/PD-L1 pathway has become a powerful clinical strategy for treating cancer, but its efficacy is complicated by various resistance mechanisms. One of reasons internalization and recycling PD-L1 itself upon antibody binding. The lysosome-mediated degradation critical preserving amount back to cell membrane. In this study, we find that Hsc70 promotes through endosome-lysosome reduces This effect dependent on Hsc70-PD-L1 binding which inhibits...
Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous cardiovascular diseases. Following activation by oxLDL, monocytes adhere to cells, migrate into the subendothelial spaces then undergo differentiation macrophages, which subsequently induces formation atherosclerotic lesions. However, mechanisms underlying macrophage oxLDL-treated remain unclear. In present study, it was demonstrated that exosomal...
The transition from meiotic spermatocytes to postmeiotic haploid germ cells constitutes an essential step in spermatogenesis. epigenomic regulatory mechanisms underlying this remain unclear. Here, we find a prominent transcriptomic switch the late early round spermatids during meiotic-to-postmeiotic transition, which is associated with robust histone acetylation changes across genome. Among deacetylases (HDACs) and acetyltransferases, that HDAC3 selectively expressed stages. Three...
Gallium oxide (Ga2O3), an ultrawide bandgap semiconductor, is ideal material for solar-blind photodetectors, but challenges such as low responsivity and response speed persist. In this paper, one-dimensional (1D) Ga2O3 nanorods were designed to achieve high photodetection performance due their effective light absorption field confinement. Through modulating source concentration, pH value, temperature, reaction time, 1D β-Ga2O3 controllably fabricated using a cost-effective hydrothermal...
Abstract This study aimed to examine clinical features, sleep, abnormal sleep-wake transition and non-sleep disturbances as well lab tests in Chinese fatal familial insomnia (FFI) subjects. Patients with confirmed laboratory diagnosis of FFI have been retrospectively reviewed. The features the results complementary tests, including polysomnography (PSG), brain imaging genetic analysis, were used. Two male three female patients recruited this study. Three five had more comprehensive family...
Oxidized low-density lipoprotein (oxLDL) has a critical role in the development of atherosclerosis. The participation oxLDL‑stimulated macrophages been well‑established atherosclerosis, however underlying mechanisms are unclear. Macrophage‑derived exosomes actively released and involved numerous physiological pathological processes. However, function secreted by atherosclerosis remains unknown. Exosomes from oxLDL‑treated controls were co‑cultured with endothelial cells taken up endocytosis....
Long non-coding RNAs (lncRNAs) have been the focus of ongoing research in a diversity cellular processes. LncRNAs are abundant mammalian testis, but their biological function remains poorly known.Here, we established an antisense oligonucleotides (ASOs)-based targeting approach that can efficiently knock down lncRNA living mouse testis. We cloned full-length transcript Tsx (testis-specific X-linked) and defined its testicular localization pattern. Microinjection ASOs through seminiferous...
Introduction: Elongation of very long-chain fatty acids protein 6 (ELOVL6) played crucial roles in regulating energy expenditure and acid metabolism. Many studies have performed to investigate the physiological regulatory mechanisms elovl6 fish animals, while few were reported crustaceans. Methods: Here we on molecular cloning, tissue distribution expression profiles response dietary acids, ambient salinity starvation stress Scylla paramamosain by using rapid amplification cDNA ends (RACE)...
Primary Sjögren's syndrome (pSS) is an autoimmune disease affecting exocrine glands. Both autoreactive T cells and B are involved in the development of pSS, but their exact contribution to pathogenesis not clear. Here, we aimed investigate association B-cell activating factor (BAFF) interleukin (IL)-17A with subphenotypes pSS.Peripheral blood samples were collected from 31 pSS patients 28 healthy controls. The serum levels BAFF IL-17A quantified by sandwich ELISA.The increased circulating...
As rate-limiting enzymes of β-oxidation fatty acids in mitochondria, the carnitine palmitoyltransferase (CPT) played an important role regulating energy homeostasis aquatic animals. However, there was very little research on crustaceans. In present study, full-length cDNA sequences cpt-1a , cpt-1b and cpt-2 were isolated from hepatopancreas Scylla paramamosain contained 4206, 5303 3486 bp respectively. Sequence analysis showed that CPT-1A, CPT-1B CPT-2 encoded proteins with 777, 775 672...
Objective Little is known about the a ssociation between plasma homocysteine (Hcy) and e ndothelial progenitor cells (EPCs) in coronary artery disease (CAD).Methods Blood mononuclear were isolated from CAD (n = 30) patients non-CAD controls 30). Flow cytometric analysis an vitro c ulture system was used to evaluate number function of EPC. Plasma concentration measured by automated fl uorescence polarization immunoassay.Results Hcy level higher than (13.69 ± 4.48 vs9.34 2.31 μmol/L, P <...
Abstract We previously reported that ibandronate (IBAN) could improve endothelial function in spontaneously hypertensive rats. However, the mechanism by which IBAN improves is unclear. The IBAN-induced autophagic process vitro experiments were determined detection of LC3, Beclin1, and P62 protein levels via western blotting. autophagy flux was detected confocal microscopy transmission electron microscopy. For vivo experiments, rats orally administered with IBAN. Utilizing angiotensin II (Ang...
To evaluate a two-test strategy for HIV screening in the low-prevalence population and to assess feasibility of utilizing optimal signal-to-cutoff (S/CO) threshold on chemiluminescence immunoassay(CMIA) an additional rapid test gold immune-chromatography assay (GICA) positive patients optimization clinical management.We conducted retrospective study samples analyzed by fourth-generation Architect Ag/Ab combo (CMIA) large medical center between June 2017 August 2020. Reactive underwent second...