A5102877071- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Immunotherapy and Immune Responses
- Reproductive Biology and Fertility
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Phagocytosis and Immune Regulation
- Block Copolymer Self-Assembly
- Mesenchymal stem cell research
- Dermatology and Skin Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Diabetes and associated disorders
- Polymer Surface Interaction Studies
- Virus-based gene therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Chinese Academy of Medical Sciences Dermatology Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Baylor College of Medicine
2024
Jilin University
2024
Peking Union Medical College Hospital
2023-2024
Nanjing Medical University
2018-2021
National Institutes of Health
2017
National Institute of Dental and Craniofacial Research
2017
The transition from meiotic spermatocytes to postmeiotic haploid germ cells constitutes an essential step in spermatogenesis. epigenomic regulatory mechanisms underlying this remain unclear. Here, we find a prominent transcriptomic switch the late early round spermatids during meiotic-to-postmeiotic transition, which is associated with robust histone acetylation changes across genome. Among deacetylases (HDACs) and acetyltransferases, that HDAC3 selectively expressed stages. Three...
Transcription factors of the Sox protein family contain a DNA-binding HMG box and are key regulators progenitor cell fate. Here, we report that expression Sox30 is restricted to meiotic spermatocytes postmeiotic haploids. mutant males sterile due spermiogenic arrest at early round spermatid stage. Specifically, in absence Sox30, proacrosomic vesicles fail form single acrosomal organelle, spermatids step 2-3. Although most progress through meiosis, accumulation diplotene indicates delayed or...
Immune thrombocytopenia(ITP)is a common clinical manifestation of systemic lupus erythematosus(SLE). Drug therapy includes glucocorticoids(GCs),disease-modifying anti-rheumatic drugs (DMARDs) and biologics. Refractory thrombocytopenia can be life-threatening, the use effective medications plays crucial role in disease improvement. Here, we report case ITP secondary to SLE. The dexamethasone(DEX), cyclosporine A(CsA), hetrombopag resulted drug-induced liver injury. Subsequently, telitacicept...
Cysteinyl leukotriene receptor 1 (CYSLTR1) is observed to increase in psoriatic skin lesions.Montelukast, a CYSLTR1 antagonist, effectively treats inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, and atopic dermatitis.Thus, blocking may be promising strategy for psoriasis immunotherapy.We prepared montelukast sodium cream solution investigated their effects on psoriasis-like lesions induced by imiquimod (IMQ).After the treatment, serum, skin, spleen samples were...
Summary Synthetic oligodeoxynucleotides (ODN) expressing ‘suppressive’ TTAGGG motifs down-regulate a variety of proinflammatory and T helper type 1 (Th1)-mediated pathological immune responses. The ability the archetypal suppressive ODN A151 to inhibit ocular inflammation was examined in two murine models: experimental autoimmune uveitis, induced by immunization with retinal antigen, interphotoreceptor retinoid-binding protein (IRBP) adoptively transferred inflammation, transferring Th1...
Immune checkpoints (ICs) play a pivotal role in orchestrating immune regulation, crucial for the maintenance of tolerance and prevention autoimmune diseases. One noteworthy example among these regulators is T cell immunoglobulin (Ig) immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT). The TIGIT pathway’s inhibition or absence has been linked to hyperactivation excessive proliferation cells, rendering individuals more susceptible diseases exacerbating inflammatory responses....
Abstract Genetic variants of the OX40 ligand (OX40L) locus are associated with risk systemic lupus erythematosus (SLE), it is unclear how OX40L blockade delays phenotype. Therefore, we examined effects an anti‐OX40L antibody in MRL/Lpr mice. Next, investigated effect on immunosuppression keyhole limpet hemocyanin‐immunized C57BL/6J In vitro treatment CD4 + T and B220 B cells was used to explore role pathogenesis SLE. Anti‐OX40L alleviated murine nephritis, accompanied by decreased production...
Abstract Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness. To address this limitation, our focus was on CD132, subunit common to six inflammatory receptors implicated in SLE. Our study revealed heightened CD132 expression SLE patients’ lymphocytes, contributing the production of pro-inflammatory cytokines and immunoglobulins. We developed novel humanized anti-CD132 monoclonal antibody, named as 2D4. 2D4 efficiently...
ABSTRACT The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious HDAC depletion. Here, we use HDAC3 as a prototype to address this contradiction. We show that adult-onset cardiac-specific depletion in mice causes cardiac hypertrophy and contractile dysfunction on high-fat diet (HFD), excluding developmental disruption major reason for Genetically abolishing enzymatic activity without affecting its protein level does not cause HFD. robust...
Abstract Objectives OX40 ligand (OX40L) locus genetic variants have relationships with the risk for systemic lupus erythematosus (SLE), OX40L blockade has been shown to ameliorate renal damage and suppress autoantibody production in NZB/W F1 mice. However, it is unclear how delays phenotype. Methods In present study, we examined impact of blocking using anti-OX40L MRL/lpr murine model lupus. Mice were sorted into 3 groups 9 ~ 11 mice per group as follows: IgG treatment, Cyclophosphamide...