A5027361354- Coronary Interventions and Diagnostics
- Systemic Lupus Erythematosus Research
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Gut microbiota and health
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Mycobacterium research and diagnosis
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Plant nutrient uptake and metabolism
- RNA Research and Splicing
- Plant Molecular Biology Research
- Gout, Hyperuricemia, Uric Acid
- Art, Politics, and Modernism
- Psoriasis: Treatment and Pathogenesis
- Plant Stress Responses and Tolerance
- Autoimmune and Inflammatory Disorders Research
- Clusterin in disease pathology
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2022-2024
Nanjing Normal University
2021-2022
Baoding People's Hospital
2013-2019
Zhoukou Normal University
2017
NCAPD3 is one of the three non-SMC subunits condensin II complex, which plays an important role in chromosome condensation and segregation during mitosis. Notably, elevated levels are found many somatic cancers. However, clinical role, biological functions cancers especially colorectal cancer (CRC) underlying molecular mechanisms remain poorly elucidated.Clinical CRC adjacent normal tissues were used to confirm expression NCAPD3. The association with clinicopathological characteristics...
Macrophage-associated inflammation and keratinocytes excessive proliferation inflammatory cytokines secretion induced by stimulation play an important role in the progression of psoriasiform dermatitis. However, how these two types cells communicate remains obscure.
Abstract Noncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of SLE pathogenesis remains unclear and contentious, with limited understanding 11‐mediated this condition. In study, we explored level SLE, identifying both upstream pathways interaction between adaptive immune responses. We observed increased 5/11 GSDMD‐dependent...
Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with substantial phenotypic heterogeneity. Currently, our understanding of the pathogenesis still limited, and as result, specific efficacious therapies are lacking. Various mouse models have been established to serve powerful tools that will promote better ability test novel drugs before clinical application.Areas covered The authors review existing SLE in terms manifestations, well their applications drug...
Abstract Background Androgen receptor (AR) is an essential transcriptional factor that contributes to the development and progression of prostate cancer (PCa). NCAPD3 a component condensin II complex plays critical role in cell mitosis by regulating chromosome condensation; however, relationship between AR remains unknown. Methods Transcriptome sequencing assay carried out analyze expression NCAP family clinic samples. Chromatin immunoprecipitation (ChIP) sequencing, ChIP assay,...
<h3>Objectives</h3> With compared of Firebird stent and Excel Stent to evaluate the safety efficacy polymer-free paclitaxel-eluting YINYI in percutaneous coronary intervention. <h3>Methods</h3> A total 360 heart disease patients were enrolled study from January 2009 Dec 2010 our hospital. All these divided into group 118 cases, 130 cases group, 112 group. The instant successful rate interventional therapy, restenosis target vessel revascularisation major adverse cardiavascular events...
To discuss the influence of coronary artery lesion elderly patients with heart disease (CHD) on left ventricular remodeling.Retrospective selection method was used to choose 80 CHD who received angiogram examination in Baoding First Central Hospital from January 2014 February 2018 as objects study. According lesion, were classified into single vessel group (single group) and multi-vessel (multi-vessel group, number vessels≧2). Single included 60 patients, includes 20 patients. Intravascular...
<h3>Objectives</h3> To evaluate the safety and efficacy of modified Y-stenting technique drug-eluting stents with biodegradable polymer applied to treat bifurcation lesions coronary artery. <h3>Methods</h3> A total 86 heart disease patients diagnosed by artery angiography were enrolled in study from April 2009 Dec. 2010 NO1 Central Hospital Baoding City. Of these patients, 36 treated using Crush technique, 50 technique. The instant successful rate interventional therapy, major adverse...
<h3>Objectives</h3> The goal of this study was to evaluate the safety and feasibility early angioplasty within 12 hours selective 1 week later after successful thrombolysis in acute ST segment elevation myocardial infarction. <h3>Methods</h3> A total 224 patients with infarction received reteplase were randomly assigned PCI (E-PCI) group or (S-PCI) group. Patients E-PCI interventional procedure randomisation, S-PCI randomisation. primary end point a combined points consisting death,...