A5012675662- Lung Cancer Treatments and Mutations
- Dermatology and Skin Diseases
- Cancer Mechanisms and Therapy
- Chronic Kidney Disease and Diabetes
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Peroxisome Proliferator-Activated Receptors
- Allergic Rhinitis and Sensitization
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Autophagy in Disease and Therapy
- Advanced Glycation End Products research
- Reproductive System and Pregnancy
- Vitamin D Research Studies
- Inflammasome and immune disorders
- Colorectal Cancer Treatments and Studies
- Pharmacological Effects of Natural Compounds
- IL-33, ST2, and ILC Pathways
- Bone Metabolism and Diseases
- Lymphoma Diagnosis and Treatment
- melanin and skin pigmentation
China Pharmaceutical University
2013-2024
Central People's Hospital of Zhanjiang
2024
Guangdong Medical College
2024
Nanjing Normal University
2021-2022
Nanjing University of Chinese Medicine
2015-2020
Abstract Background The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) brings remarkable benefits for the survival patients with advanced NSCLC harboring EGFR mutations. Unfortunately, acquired resistance seems to be inevitable and limits application EGFR-TKIs in clinical practice. This study reported a common molecular mechanism sustaining potential treatment options overcome resistance. Methods resistant cells were established confirmed by MTT assay....
NCAPD3 is one of the three non-SMC subunits condensin II complex, which plays an important role in chromosome condensation and segregation during mitosis. Notably, elevated levels are found many somatic cancers. However, clinical role, biological functions cancers especially colorectal cancer (CRC) underlying molecular mechanisms remain poorly elucidated.Clinical CRC adjacent normal tissues were used to confirm expression NCAPD3. The association with clinicopathological characteristics...
Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is pivotal pathological feature of asthma. The relationship between claudin1 expression EGFR still poorly understood. In this report, we showed that correlated with asthma stage, both patients house dust mite (HDM)-induced mouse model. knockdown MUC5AC overexpression 16HBE cells airways. addition, negatively severity as demonstrated...
Abstract Recent studies have demonstrated that microRNA-155-5p (miR-155-5p) plays an essential role in the regulation of allergen-induced inflammation and is overexpressed skin patients with atopic dermatitis (AD), although mechanism unknown. In this study, silencing miR-155-5p attenuated thickening epidermis AD model reduced infiltration inflammatory cells secretion Th2 cytokines. Protein kinase inhibitor α (PKIα) was identified as a direct target correlated negatively our model....
Tubulointerstitial fibrosis is one of the most common pathological features diabetic nephropathy. Autophagy, an intracellular mechanism to remove damaged or dysfunctional cell parts and maintain metabolic homeostasis, inhibited in neuropathy. Icariin a traditional Chinese medicine extract known for nourishing kidney reinforcing Yang. In this study, we investigated effects on renal function, autophagy, type 2 nephropathic rats high-glucose-incubated human tubular epithelial cells rat...
Abstract Calycosin, a bioactive component derived from Astragali Radix ( AR ; Huang Qi), has been shown to have an effect of anti‐allergic dermatitis with unknown mechanism. This study aims investigate the mechanism calycosin related tight junctions TJ s) and HIF ‐1α both in FITC ‐induced mice allergic contact IL ‐1β stimulated HaCaT keratinocytes. Th2 cytokines ‐4, ‐5 ‐13) were detected by ELISA . The epithelial proteins (occludin, CLDN 1 ZO ‐1), initiative key TSLP ‐33) assessed Western...
Abstract Recent studies have demonstrated that acquisition of cancer stem-like properties plays an essential role in promoting epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistance non-small cell lung (NSCLC); however, how to regulate and EGFR-TKI is largely unclear. In this study, we discovered increased iroquois-class homeodomain protein 4 (IRX4) was related gefitinib NSCLC cells. Knockdown IRX4 inhibited proliferation, sphere formation, the expression CD133,...
In this study, we examined anti-fungal and anti-inflammatory effects of the synthetic melanocortin peptide (Ac-Cys-Lys-Pro-Val-NH2)2 or (CKPV)2 against Candida albicans vaginitis. Our in vitro results showed that dose-dependently inhibited colonies formation. a rat vaginitis model, significantly vaginal survival macrophages sub-epithelial mucosa infiltration. For mechanisms observed phagocytosis albicans. Meanwhile, administration macrophage pro-inflammatory cytokines (TNF-α, IL-1β IL-6)...
Claudins, the integral tight junction proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their roles regulating EGFR tyrosine kinase inhibitors (EGFR-TKIs) resistance non-small lung cancer (NSCLC) unknown. To this end, we performed GEO dataset analysis identified claudin1 was a critical regulator of EGFR-TKI NSCLC cells. We also found claudin1, which highly induced by continuous gefitinib treatment, significantly upregulated...
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Clinically, the treatments against asthma like β2 agonist focus on controlling symptoms rather than inhibiting recurrence radically. This study aims to evaluate efficacy and mechanism of a potent Chinese prescription Yu-Ping-Feng-San (YPFS) recurrence. We here established an optimized house dust mite (HDM)-induced mice model with typical asthmatic responses such as significantly augmented airway hyperresponsiveness (AHR), elevated serum IgE, pulmonary type 2 cytokines IL-5 IL-13 levels,...
Non-small cell lung cancer (NSCLC) is the most common type of cancer. Gefitinib a first-line treatment for NSCLC. However, its effectiveness hindered by development drug resistance. At present, Shenqi Fuzheng injection (SFI) widely accepted as an adjuvant therapy in
Diabetic nephropathy is a common complication of diabetes, accumulating evidence underscores the pivotal role tubulointerstitial fibrosis in progression diabetic nephropathy. However, underlying mechanisms remain incompletely understood. Although have been focus many studies, only limited information currently available concerning microRNA regulation fibrosis. In this study, we aimed to investigated roles miR-320a-3p and bone morphogenetic protein-6 (BMP6) After inducing with high glucose...
<title>Abstract</title> Our previous studies have demonstrated that 1,25-dihydroxyvitamin D3 (1,25(OH)<sub>2</sub>D<sub>3</sub>) inhibits epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) resistance in non-small cell lung cancer (NSCLC); however, the role of vitamin D (VDR) regulating NSCLC EGFR-TKIs is unknown. To this end, we detected VDR expression EGFR-TKI sensitive and resistant cells, found was increased significantly cells. By knocking-down both lines xenograft...
The aim of this retrospective study is to evaluate the impact on efficacy and safety between epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) alone in combination with Shenqi Fuzheng injection (SFI) patients advanced NSCLC harboring (EGFR) activating mutations.Retrospectively, information 88 receiving EGFR-TKIs as first-line targeted treatment or SFI Affiliated Drum Tower Hospital Nanjing University Medical College Cancer Anhui Science Technology was collected. primary...
Although gefitinib brings about tremendous advances in the treatment of non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations, most patients become incurable due to drug resistance. JuBei oral liquid (JB) has been widely used treat pneumonia clinic. Components JB were reported induce apoptosis NSCLC, which indicated that could be a potential antitumor agent for NSCLC patients. In this study, we investigated effect on gefitinib-sensitive PC-9 and...